Detailed information for compound 201773

Basic information

Technical information
  • TDR Targets ID: 201773
  • Name: cyclopentyl-[8-methoxy-4-(2-methylanilino)qui nolin-3-yl]methanone
  • MW: 360.449 | Formula: C23H24N2O2
  • H donors: 1 H acceptors: 2 LogP: 5.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1ncc(c2Nc1ccccc1C)C(=O)C1CCCC1
  • InChi: 1S/C23H24N2O2/c1-15-8-3-6-12-19(15)25-21-17-11-7-13-20(27-2)22(17)24-14-18(21)23(26)16-9-4-5-10-16/h3,6-8,11-14,16H,4-5,9-10H2,1-2H3,(H,24,25)
  • InChiKey: NVBZLGYBAAWBAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • cyclopentyl-[8-methoxy-4-(2-methylanilino)-3-quinolyl]methanone
  • cyclopentyl-[8-methoxy-4-[(2-methylphenyl)amino]quinolin-3-yl]methanone
  • cyclopentyl-[8-methoxy-4-(o-toluidino)-3-quinolyl]methanone
  • cyclopentyl-[8-methoxy-4-[(2-methylphenyl)amino]-3-quinolyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Potassium-transporting ATPase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.3 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 24.1 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Potassium-transporting ATPase   290 aa 258 aa 24.4 %
Onchocerca volvulus Glutamate carboxypeptidase 2 homolog Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Drosophila melanogaster nervana 1 Potassium-transporting ATPase   290 aa 305 aa 23.9 %
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Potassium-transporting ATPase   290 aa 258 aa 23.6 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.6 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 21.3 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 25.6 %
Loa Loa (eye worm) hypothetical protein Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta, putative Potassium-transporting ATPase   290 aa 256 aa 25.4 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 254 aa 23.6 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 265 aa 22.3 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 306 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0112 0.0246
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.0291
Trypanosoma brucei calcium-translocating P-type ATPase 0.0014 0.0058 0.0192
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0102 0.0511
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.001 0.001
Echinococcus multilocularis geminin 0.0145 0.1767 0.1759
Mycobacterium ulcerans hypothetical protein 0.0034 0.0325 0.0531
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.5552 0.5547
Leishmania major calcium-transporting ATPase, putative 0.0014 0.0058 0.0192
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 0.1757
Treponema pallidum pfs protein (pfs) 0.009 0.1055 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.001 0.0009
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0434 0.5552 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.001 0.0013
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.1001 0.1788
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0112 0.0562
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0164
Mycobacterium tuberculosis Conserved protein 0.0034 0.0325 0.0531
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0082 0.032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0082 0.0429
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0215 0.0379
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0125 0.0114
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0464 0.0818
Toxoplasma gondii ABC1 family protein 0.0034 0.0325 0.1693
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0102 0.0129
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0082 0.0429
Giardia lamblia Deoxynucleoside kinase 0.04 0.5098 0.9174
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.00000000023075
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0102 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0731
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0102 0.0175
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0082 0.013
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0017 0.0102 0.0166
Mycobacterium leprae probable uridine phosphorylase 0.009 0.1055 0.1854
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0112 0.0147
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Schistosoma mansoni ATPase 0.0017 0.0102 0.0176
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0266 0.1389
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0325 0.0577
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0325 0.0531
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0595 0.1351
Loa Loa (eye worm) steroid hormone receptor 0.001 0.001 0.0013
Plasmodium falciparum thioredoxin reductase 0.0015 0.0082 0.013
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.136 0.2408
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0082 0.0406
Loa Loa (eye worm) uridine phosphorylase 0.009 0.1055 0.2401
Leishmania major hypothetical protein, conserved 0.0034 0.0325 0.1598
Chlamydia trachomatis AMP nucleosidase 0.009 0.1055 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0009
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0102 0.1212 0.2138
Loa Loa (eye worm) beta-lactamase 0.0034 0.0325 0.0731
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0014 0.0058 0.0303
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0058 0.0096
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0082 0.032
Schistosoma mansoni hypothetical protein 0.0017 0.0106 0.0183
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.001
Echinococcus granulosus GPCR family 2 0.0017 0.0106 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.001 0.001
Mycobacterium tuberculosis Probable reductase 0.0102 0.1212 0.2138
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0058 0.0096
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0045 0.047 0.0795
Echinococcus multilocularis thymidylate synthase 0.0111 0.1327 0.1318
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0125 0.0215
Plasmodium vivax purine nucleoside phosphorylase, putative 0.009 0.1055 0.55
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.0022 0.0088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 0.945
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0014 0.0058 0.0086
Schistosoma mansoni uridine phosphorylase 0.009 0.1055 0.1892
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0102 0.0972
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0125 0.0121
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0058 0.0066
Echinococcus multilocularis nervana 2 0.0026 0.0215 0.0205
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0014 0.0058 0.0096
Trypanosoma cruzi nucleoside phosphorylase, putative 0.009 0.1055 0.5489
Leishmania major calcium-translocating P-type ATPase 0.0017 0.0102 0.0427
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0731
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.009 0.1055 0.5448
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0615 0.0605
Mycobacterium tuberculosis Conserved protein 0.0034 0.0325 0.0531
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.1055 0.1854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.0406
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.1001 0.5221
Loa Loa (eye worm) hypothetical protein 0.0055 0.0595 0.1351
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0125 0.0544
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0325 0.0548
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0125 0.0215
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0112 0.1064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0451 0.102
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0012 0.0031 0.006
Leishmania major P-type ATPase, putative 0.0014 0.0058 0.0192
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0017 0.0102 0.0535
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.001 0.0013
Mycobacterium ulcerans lipase LipD 0.0034 0.0325 0.0531
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0464 0.0784
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.047 0.0795
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0106 0.0096
Giardia lamblia UPL-1 0.009 0.1055 0.1814
Schistosoma mansoni purine nucleoside phosphorylase 0.0434 0.5552 1
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0102 0.0081
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0434 0.5552 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.136 0.2408
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0125 0.0186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.0406
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0125 0.0186
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0325 0.1693
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0082 0.0139
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0215 0.0369
Schistosoma mansoni methylthioadenosine phosphorylase 0.009 0.1055 0.1892
Mycobacterium leprae Probable lipase LipE 0.0034 0.0325 0.0531
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.136 0.2408
Schistosoma mansoni hypothetical protein 0.0017 0.0106 0.0183
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0106 0.0173
Entamoeba histolytica hypothetical protein 0.009 0.1055 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.009 0.1055 1
Trichomonas vaginalis conserved hypothetical protein 0.009 0.1055 0.1868
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.047 0.3989
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.0194
Onchocerca volvulus 0.0026 0.0215 0.0369
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.009 0.1055 1
Onchocerca volvulus 0.0111 0.1327 0.2376
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0014 0.0058 0.0279
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0106 0.0173
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.5552 0.5547
Schistosoma mansoni DNA helicase recq1 0.0019 0.0125 0.0216
Brugia malayi dihydrofolate reductase family protein 0.0045 0.047 0.0838
Schistosoma mansoni DNA helicase recq5 0.0019 0.0125 0.0216
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0131 0.1594 0.8314
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.032
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.1001 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0569 0.0989
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.001 0.0013
Toxoplasma gondii P-type ATPase PMA1 0.0011 0.0022 0.0113
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0215 0.0369
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0102 0.1212 0.2138
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0082 0.0093
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0014 0.0058 0.0086
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0325 0.0531
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0112 0.0184
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0146
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0325 0.0314
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.5552 0.5547
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.5552 0.5547
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0434 0.5552 1
Brugia malayi beta-lactamase 0.0034 0.0325 0.0575
Brugia malayi MH2 domain containing protein 0.0131 0.1593 0.2863
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0464 0.2419
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0156 0.1917 1
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0325 0.0548
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0972
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0325 0.0577
Echinococcus granulosus nervana 2 0.0026 0.0215 0.0369
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0125 0.0114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.001 0.001
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0464 0.105
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0017 0.0102 0.0511
Schistosoma mansoni transmemberane protein 0.0026 0.0215 0.0379
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0325 0.0531
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0111 0.1327 0.2384
Echinococcus multilocularis nervana 2 0.0026 0.0215 0.0205
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0082 0.014
Schistosoma mansoni ATPase 0.0017 0.0102 0.0176
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0112 0.1024
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0102 0.0427
Trypanosoma brucei trypanothione reductase 0.0045 0.0464 0.2333
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0017 0.0102 0.0239
Echinococcus multilocularis uridine phosphorylase 1 0.009 0.1055 0.1045
Toxoplasma gondii hypothetical protein 0.003 0.0266 0.1389
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0224
Echinococcus multilocularis purine nucleoside phosphorylase 0.0344 0.4377 0.4372
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0325 0.0531
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0058 0.0096
Schistosoma mansoni hypothetical protein 0.0145 0.1767 0.3177
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0731
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0146
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0102 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0112 0.0325
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.1001 0.1796
Plasmodium falciparum purine nucleoside phosphorylase 0.009 0.1055 0.5359
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0082 0.0429
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0017 0.0102 0.0129
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0014 0.0058 0.0048
Trypanosoma cruzi nucleoside phosphorylase, putative 0.009 0.1055 0.5489
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0111 0.1327 0.2348
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0731
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.001 0.0009
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0274
Schistosoma mansoni dihydrofolate reductase 0.0045 0.047 0.0839
Echinococcus granulosus geminin 0.0145 0.1767 0.317
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0451 0.0803
Brugia malayi beta-lactamase family protein 0.0034 0.0325 0.0575
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0102 0.1212 0.2138
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0325 0.0531
Entamoeba histolytica recQ family DNA helicase 0.001 0.0005 0.0045
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0615 0.1091
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.1001 0.0992
Echinococcus granulosus nervana 2 0.0026 0.0215 0.0369
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0082 0.0072
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0012 0.0031 0.0046
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.009 0.1055 0.1854
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.0569 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0325 0.1672
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0102 0.0427
Treponema pallidum NADH oxidase 0.0015 0.0082 0.0739
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0325 0.0548
Plasmodium vivax P-type ATPase4, putative 0.0017 0.0102 0.0535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0224
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.001 0.001
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0972
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0112 0.0193
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0125 0.0358
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.009 0.1055 1
Mycobacterium tuberculosis Conserved protein 0.0034 0.0325 0.0531
Toxoplasma gondii phosphorylase family protein 0.009 0.1055 0.55
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0112 0.0147
Schistosoma mansoni uridine phosphorylase 0.009 0.1055 0.1892
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0102 0.0092
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.009 0.1055 0.1814
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0369 0.0833
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0325 0.0531
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0014 0.0058 0.0048
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0102 0.1212 0.2138
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0082 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.001 0.0013
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.047 0.0795
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0082 0.011
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0102 0.0535
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.048
Schistosoma mansoni methylthioadenosine phosphorylase 0.009 0.1055 0.1892
Onchocerca volvulus 0.0034 0.0325 0.0567
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.001
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0215 0.0205
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0106 0.0182
Leishmania major nucleoside phosphorylase-like protein 0.009 0.1055 0.5448
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.136 0.2408
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0972
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0325 0.0731
Mycobacterium ulcerans thymidylate synthase 0.0111 0.1327 0.2348
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0344 0.4377 0.7881
Loa Loa (eye worm) RecQ helicase 0.0019 0.0125 0.0274
Schistosoma mansoni hypothetical protein 0.0017 0.0106 0.0183
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0464 0.24
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0102 0.0224
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.009 0.1055 0.1854
Plasmodium falciparum glutathione reductase 0.0015 0.0082 0.013
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.0022 0.0088
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0125 0.0274
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0082 0.011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0325 0.0531
Toxoplasma gondii thioredoxin reductase 0.0045 0.0464 0.2419
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0615 0.1057
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.5552 0.5547
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0451 0.0795
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.009 0.1055 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0082 0.0093
Echinococcus granulosus nervana 2 0.0026 0.0215 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.001 0.0009
Brugia malayi hypothetical protein 0.0053 0.0569 0.1015
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0102 0.0176
Brugia malayi glutathione reductase 0.0045 0.0464 0.0827
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0125 0.0215
Echinococcus granulosus thymidylate synthase 0.0111 0.1327 0.2376
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.0569 0.2948
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0325 0.0531
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0106 0.0182
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0082 0.013
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0434 0.5552 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0009
Echinococcus granulosus Na:K ATPase alpha subunit 0.0014 0.0058 0.0086
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0434 0.5552 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.001 0.0013
Brugia malayi thymidylate synthase 0.0111 0.1327 0.2383
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0009
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0125 0.0114
Brugia malayi nuclear hormone receptor 0.001 0.001 0.0009
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0058 0.0096
Brugia malayi beta-lactamase family protein 0.0034 0.0325 0.0575
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0026 0.0215 0.0205
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0106 0.0096
Brugia malayi steroid hormone receptor 0.001 0.001 0.0009
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Leishmania major methylthioadenosine phosphorylase, putative 0.009 0.1055 0.5448
Plasmodium falciparum glutathione reductase 0.0045 0.0464 0.2182
Leishmania major calcium motive p-type ATPase, putative 0.0014 0.0058 0.0192
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0156 0.1917 1
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0014 0.0058 0.0048
Trichomonas vaginalis esterase, putative 0.0034 0.0325 0.0548
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.009 0.1055 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0112 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.001 0.0009
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0102 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1593 0.3633
Echinococcus granulosus nervana 2 0.0026 0.0215 0.0369
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0595 0.1064
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.001 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.001 0.001
Plasmodium falciparum thioredoxin reductase 0.0045 0.0464 0.2182
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0102 0.0535
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0102 0.1212 0.2138
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0215 0.0379
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0125 0.0627
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0082 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0009
Brugia malayi Dihydrofolate reductase 0.0045 0.047 0.0838
Echinococcus multilocularis methylthioadenosine phosphorylase 0.009 0.1055 0.1045
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.001 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0082 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0595 0.1064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0451 0.0795
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0029 0.0042
Echinococcus multilocularis nervana 2 0.0026 0.0215 0.0205
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.001 0.001
Plasmodium vivax calcium-transporting ATPase, putative 0.0017 0.0102 0.0535
Loa Loa (eye worm) thymidylate synthase 0.0111 0.1327 0.3024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0125 0.065
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0082 0.0406
Loa Loa (eye worm) hypothetical protein 0.0086 0.1001 0.2278
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0082 0.0406
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0156 0.1917 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0102 0.0092
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0102 0.0427
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0266 0.2491
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.009 0.1055 0.2401
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.0194
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0082 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0325 0.1598
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0434 0.5552 1
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0014 0.0058 0.0192
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0014 0.0058 0.0279
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1593 0.3633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.0406
Schistosoma mansoni methylthioadenosine phosphorylase 0.009 0.1055 0.1892
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.009 0.1055 0.5489
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0215 0.0205
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0026 0.0215 0.0379
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Loa Loa (eye worm) hypothetical protein 0.0017 0.0106 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.001 0.0013
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.047 0.1064
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.5552 0.5547
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1001 0.5221
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.001 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0451 0.0804
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.009 0.1055 0.1854
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0102 0.0427
Brugia malayi Thioredoxin reductase 0.0045 0.0464 0.0827
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Brugia malayi uridine phosphorylase family protein 0.009 0.1055 0.1892
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0029 0.0042
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.001 0.0005 0.0051
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0082 0.032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0451 0.0441
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0082 0.0429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0451 0.0804
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0125 0.0206
Leishmania major trypanothione reductase 0.0045 0.0464 0.2333
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0325 0.0548
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 0.945
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 0.5072
Echinococcus multilocularis GPCR, family 2 0.0017 0.0106 0.0096
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.0585
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0217 0.272 0.4871
Mycobacterium tuberculosis Probable dehydrogenase 0.0102 0.1212 0.2138
Toxoplasma gondii Purine nucleoside phosphorylase 0.009 0.1055 0.55
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0125 0.1183
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1001 0.5221
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0125 0.065
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0125 0.0358
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0102 0.0166
Brugia malayi MTAP 0.009 0.1055 0.1892
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0106 0.0232
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0325 0.0575
Echinococcus granulosus methylthioadenosine phosphorylase 0.009 0.1055 0.1884
Echinococcus multilocularis calcium transporting atpase 0.0014 0.0058 0.0048
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0266 0.0426
Schistosoma mansoni hypothetical protein 0.0145 0.1767 0.3177
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.1917 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 0.9491
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.047 0.046
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0005 0.0025
Plasmodium vivax glutathione reductase, putative 0.0045 0.0464 0.2419
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0215 0.0369
Brugia malayi Membrane calcium atpase protein 3 0.0014 0.0058 0.0095
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0125 0.0206
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.001 0.0005 0.0051
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0014 0.0058 0.0096
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0102 0.0146
Trypanosoma brucei uridine phosphorylase 0.009 0.1055 0.5448
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.009 0.1055 1
Toxoplasma gondii phosphorylase family protein 0.009 0.1055 0.55
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0111 0.1327 0.2348
Mycobacterium ulcerans beta-lactamase 0.0034 0.0325 0.0531
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0731
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0325 0.0567
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0615 0.1057
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0325 0.0548
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0102 0.0427
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0082 0.032
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0434 0.5552 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0102 0.0146
Echinococcus multilocularis purine nucleoside phosphorylase 0.0344 0.4377 0.4372
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Echinococcus granulosus dihydrofolate reductase 0.0045 0.047 0.083
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.009 0.1055 0.1814
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0325 0.1672
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0009
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0464 0.0454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.001 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0325 0.0531
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0014 0.0058 0.0095
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0102 0.0146
Onchocerca volvulus 0.0026 0.0215 0.0369
Schistosoma mansoni purine nucleoside phosphorylase 0.0434 0.5552 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0082 0.0044
Onchocerca volvulus 0.0017 0.0102 0.0166
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0017 0.0102 0.0092
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0026 0.0215 0.0369
Echinococcus multilocularis nervana 2 0.0026 0.0215 0.0205
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0325 0.0531
Mycobacterium tuberculosis Hypothetical protein 0.009 0.1055 0.1854
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0164
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.001 0.001
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0215 0.0205
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0615 0.1057
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Brugia malayi Probable ClpP-like protease 0.0086 0.1001 0.1795
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0125 0.0544
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.001 0.001
Treponema pallidum uridine phosphorylase (udp) 0.009 0.1055 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0112 0.0478
Schistosoma mansoni hypothetical protein 0.0037 0.0369 0.0657
Echinococcus granulosus bloom syndrome protein 0.0019 0.0125 0.0206
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0102 0.0511
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0266 0.112
Onchocerca volvulus 0.0034 0.0325 0.0567
Onchocerca volvulus 0.0034 0.0325 0.0567
Echinococcus granulosus purine nucleoside phosphorylase 0.0434 0.5552 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Brugia malayi ecdysteroid receptor 0.001 0.001 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0082 0.032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.0406
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0562
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 0.1757
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.1917 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.001 0.0009
Echinococcus granulosus calcium transporting atpase 0.0014 0.0058 0.0086
Trypanosoma cruzi nucleoside phosphorylase, putative 0.009 0.1055 0.5489
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.009 0.1055 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.001 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.009 0.1055 0.1868
Toxoplasma gondii exonuclease III APE 0.0018 0.0112 0.0585
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.009 0.1055 0.1868
Schistosoma mansoni hypothetical protein 0.0017 0.0106 0.0183
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.1001 1
Loa Loa (eye worm) glutathione reductase 0.0045 0.0464 0.105
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0478
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0025
Brugia malayi E1-E2 ATPase family protein 0.0011 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.048
Loa Loa (eye worm) E1-E2 ATPase 0.0011 0.0022 0.0039
Echinococcus granulosus uridine phosphorylase 1 0.009 0.1055 0.1884
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0156 0.1917 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0451 0.0804
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.009 0.1055 0.5489
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.001 0.0009
Loa Loa (eye worm) calcium ATPase 0.001 0.0005 0.0001
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0215 0.0379
Loa Loa (eye worm) hypothetical protein 0.0344 0.4377 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0082 0.0406
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0369 0.0656
Schistosoma mansoni coup transcription factor 0.001 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0451 0.0441
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0731
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0125 0.0186
Brugia malayi nuclear receptor NHR-88 0.001 0.001 0.0009
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0112 0.0099

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.7 uM Concentration required to inhibit the activity of K+ stimulated gastric ATPase ChEMBL. 1326634
IC50 (binding) = 1.7 uM Concentration required to inhibit the activity of K+ stimulated gastric ATPase ChEMBL. 1326634
Inhibition (functional) = 55.7 % Inhibition of histamine stimulated gastric acid secretion was tested in heidenhain pouch dog at 4 microM/kg upon oral administration ChEMBL. 1326634
Inhibition (functional) = 56 % Inhibition of pentagastrin stimulated gastric acid secretion in anesthetized rat at 10 umol/kg upon intravenous administration ChEMBL. 1326634
Inhibition (functional) = 56 % Inhibition of pentagastrin stimulated gastric acid secretion in anesthetized rat at 10 umol/kg upon intravenous administration ChEMBL. 1326634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.