Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0084 | 0.6253 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0086 | 0.6463 | 0.6463 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.4117 | 0.4117 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.2671 | 0.2671 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.2671 | 0.2671 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0084 | 0.6253 | 0.6253 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0122 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.6463 | 0.6463 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0086 | 0.6463 | 0.6463 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0122 | 1 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.2671 | 0.2671 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0122 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0035 | 0.1446 | 0.1446 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0035 | 0.1446 | 0.1446 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.6463 | 0.6463 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0122 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0035 | 0.1446 | 0.1446 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Brugia malayi | Protein kinase c protein 2 | 0.0066 | 0.4462 | 0.4462 |
Toxoplasma gondii | AGC kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0104 | 0.8254 | 0.8254 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2671 | 0.2671 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0051 | 0.3016 | 0.3016 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0071 | 0.5017 | 0.5017 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0071 | 0.5017 | 0.5017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.12 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserine | ChEMBL. | 25437619 |
Ki (binding) | = 12.6 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCalpha (unknown origin) in presence of 100 ug/ml 100% phosphatidylserine | ChEMBL. | 25437619 |
Ki (binding) | = 34.6 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of nuclear membrane mimetic lipid mixture | ChEMBL. | 25437619 |
Ki (binding) | = 38.7 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCalpha (unknown origin) in presence of nuclear membrane mimetic lipid mixture | ChEMBL. | 25437619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.