Detailed information for compound 201847

Basic information

Technical information
  • TDR Targets ID: 201847
  • Name: 4-[6-(2,3-dihydroxyphenyl)hexoxy]-2-hydroxy-3 -propylbenzoic acid
  • MW: 388.454 | Formula: C22H28O6
  • H donors: 4 H acceptors: 5 LogP: 6 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1c(OCCCCCCc2cccc(c2O)O)ccc(c1O)C(=O)O
  • InChi: 1S/C22H28O6/c1-2-8-16-19(13-12-17(21(16)25)22(26)27)28-14-6-4-3-5-9-15-10-7-11-18(23)20(15)24/h7,10-13,23-25H,2-6,8-9,14H2,1H3,(H,26,27)
  • InChiKey: MQSAORRAHSHSTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[6-(2,3-dihydroxyphenyl)hexoxy]-2-hydroxy-3-propyl-benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Trypsin family protein 0.0065 0.0072 0.0072
Plasmodium vivax unspecified product 0.0116 0.0541 0.1568
Brugia malayi calpain family protein 1 0.0123 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0213 0.1432 0.1432
Schistosoma mansoni cathepsin C 0.0097 0.0369 0.0369
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Plasmodium vivax RNA helicase-1, putative 0.0238 0.1663 0.5428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Loa Loa (eye worm) hypothetical protein 0.0383 0.2991 0.2991
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0167 0.1014 0.1014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0383 0.2991 0.8906
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.0182
Echinococcus granulosus enteropeptidase 0.0065 0.0072 0.0072
Plasmodium vivax serine-repeat antigen (SERA) 0.0097 0.0369 0.0977
Echinococcus multilocularis cathepsin L 0.0213 0.1432 0.1432
Plasmodium vivax vivapain-2 0.0383 0.2991 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0097 0.0369 0.0369
Onchocerca volvulus Cathepsin L homolog 0.0097 0.0369 0.1017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Treponema pallidum ATP-dependent RNA helicase 0.0238 0.1663 0.5
Trypanosoma brucei cysteine peptidase C (CPC) 0.0421 0.3348 1
Trypanosoma cruzi cysteine peptidase, putative 0.0383 0.2991 0.2931
Brugia malayi cathepsin Z-like cysteine proteinase 0.0097 0.0369 0.0369
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0099 0.0387 0.0387
Trypanosoma cruzi cysteine proteinase, putative 0.0213 0.1432 0.1358
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0097 0.0369 0.0369
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0097 0.0369 0.0977
Schistosoma mansoni lipoxygenase 0.01 0.0393 0.0393
Loa Loa (eye worm) fibroinase 0.0383 0.2991 0.2991
Echinococcus granulosus cathepsin b 0.1146 1 1
Plasmodium falciparum serine repeat antigen 9 0.0097 0.0369 0.0977
Brugia malayi Cathepsin L-like precursor 0.0116 0.0541 0.0541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0369 0.0369
Onchocerca volvulus 0.0077 0.0182 0.0376
Loa Loa (eye worm) hypothetical protein 0.0238 0.1663 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Echinococcus multilocularis tissue type plasminogen activator 0.0066 0.0086 0.0086
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0369 0.0369
Schistosoma mansoni cathepsin F (C01 family) 0.0383 0.2991 0.2991
Loa Loa (eye worm) hypothetical protein 0.0097 0.0369 0.0369
Schistosoma mansoni cathepsin S (C01 family) 0.0097 0.0369 0.0369
Trypanosoma cruzi cruzipain precursor, putative 0.0116 0.0541 0.046
Plasmodium vivax unspecified product 0.0213 0.1432 0.4635
Loa Loa (eye worm) hypothetical protein 0.0065 0.0072 0.0072
Plasmodium falciparum cysteine proteinase falcipain 3 0.0383 0.2991 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Onchocerca volvulus 0.0167 0.1014 0.3227
Brugia malayi cathepsin L precursor 0.0097 0.0369 0.0369
Schistosoma mansoni cathepsin F (C01 family) 0.0267 0.1928 0.1928
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0387 0.0387
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0238 0.1663 0.5449
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0097 0.0369 0.0977
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0091 0.031 0.031
Toxoplasma gondii cathepsin B 0.0421 0.3348 1
Plasmodium vivax unspecified product 0.0097 0.0369 0.0977
Toxoplasma gondii melibiase subfamily protein 0.0099 0.0387 0.1111
Brugia malayi Melibiase family protein 0.0066 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.0369 0.0874
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0065 0.0072 0.0072
Onchocerca volvulus 0.0103 0.042 0.1191
Toxoplasma gondii cathepsin CPL 0.0383 0.2991 0.8928
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.5599 0.5599
Brugia malayi Protein kinase domain containing protein 0.0066 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0065 0.0072 0.0072
Echinococcus multilocularis transmembrane protease serine 3 0.0065 0.0072 0.0072
Echinococcus multilocularis cathepsin L cysteine protease 0.0383 0.2991 0.2991
Echinococcus granulosus cathepsin l1 0.0267 0.1928 0.1928
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0116 0.0541 0.0541
Toxoplasma gondii preprocathepsin c precursor, putative 0.0097 0.0369 0.1058
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0072 0.0072
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0238 0.1663 0.4836
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0383 0.2991 0.8906
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0097 0.0369 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Plasmodium vivax serine-repeat antigen (SERA) 0.0097 0.0369 0.0977
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0065 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0109 0.048 0.048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0369 0.0369
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0238 0.1663 0.4342
Loa Loa (eye worm) hypothetical protein 0.0065 0.0072 0.0072
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.0084 0.0084
Giardia lamblia Cathepsin B precursor 0.0421 0.3348 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0213 0.1432 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Trypanosoma cruzi cysteine proteinase, putative 0.0213 0.1432 0.1358
Plasmodium falciparum serine repeat antigen 8 0.0097 0.0369 0.0977
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0072 0.0072
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Plasmodium falciparum serine repeat antigen 4 0.0097 0.0369 0.0977
Leishmania major cysteine peptidase A (CPA) 0.0383 0.2991 0.8928
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0383 0.2991 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0072 0.0072
Onchocerca volvulus 0.0383 0.2991 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Brugia malayi Cathepsin L-like precursor 0.0383 0.2991 0.2991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0097 0.0369 0.0977
Plasmodium falciparum serine repeat antigen 1 0.0097 0.0369 0.0977
Toxoplasma gondii cathepsin CPC2 0.0097 0.0369 0.1058
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0097 0.0369 0.0369
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0387 0.0387
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0097 0.0369 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0097 0.0369 0.0874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1432 0.413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0097 0.0369 0.0874
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Trypanosoma cruzi cysteine protease, putative 0.0213 0.1432 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0369 0.0874
Echinococcus granulosus Mastin 0.0065 0.0072 0.0072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0383 0.2991 0.2991
Plasmodium falciparum serine repeat antigen 7 0.0097 0.0369 0.0977
Echinococcus granulosus cathepsin L cysteine proteinase 0.0383 0.2991 0.2991
Loa Loa (eye worm) DEAH box polypeptide 35 0.05 0.4073 0.4073
Brugia malayi Trypsin family protein 0.0065 0.0072 0.0072
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0129 0.066 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0097 0.0369 0.0874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0387 0.0387
Onchocerca volvulus Cathepsin F homolog 0.0383 0.2991 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1146 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0383 0.2991 0.2931
Entamoeba histolytica cysteine proteinase, putative 0.0383 0.2991 1
Echinococcus granulosus cathepsin b 0.1146 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.0369 0.0369
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0129 0.066 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.0369 0.0874
Loa Loa (eye worm) hypothetical protein 0.0066 0.0084 0.0084
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0238 0.1663 0.1591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0097 0.0369 0.0874
Plasmodium falciparum serine repeat antigen 6 0.0097 0.0369 0.0977
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0097 0.0369 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0369 0.0874
Loa Loa (eye worm) TK/ROR protein kinase 0.0066 0.0086 0.0086
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0238 0.1663 0.1591
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0097 0.0369 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Onchocerca volvulus 0.0383 0.2991 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0238 0.1663 0.4836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.0369 0.0874
Schistosoma mansoni cathepsin F (C01 family) 0.0383 0.2991 0.2991
Brugia malayi cathepsin L-like precursor 0.0267 0.1928 0.1928
Brugia malayi Trypsin family protein 0.0167 0.1014 0.1014
Loa Loa (eye worm) hypothetical protein 0.0267 0.1928 0.1928
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0072 0.0072
Brugia malayi hypothetical protein 0.0065 0.0072 0.0072
Brugia malayi cathepsin F-like cysteine proteinase 0.0116 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0097 0.0369 0.0369
Plasmodium falciparum eukaryotic initiation factor 4A 0.0238 0.1663 0.5428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Brugia malayi Cathepsin L-like precursor 0.0383 0.2991 0.2991
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0097 0.0369 0.0369
Onchocerca volvulus 0.0383 0.2991 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0369 0.0369
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Brugia malayi Cathepsin L-like precursor 0.0383 0.2991 0.2991
Loa Loa (eye worm) hypothetical protein 0.0097 0.0369 0.0369
Brugia malayi Papain family cysteine protease containing protein 0.0383 0.2991 0.2991
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.1432 0.4054
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0238 0.1663 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0097 0.0369 0.0874
Schistosoma mansoni hypothetical protein 0.0065 0.0072 0.0072
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Plasmodium falciparum serine repeat antigen 5 0.0097 0.0369 0.0977
Brugia malayi calpain family protein 1 0.0123 0.0608 0.0608
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0097 0.0369 0.0977
Brugia malayi Probable ATP-dependent helicase DHX35 0.05 0.4073 0.4073
Brugia malayi Trypsin-like protease protein 5 0.0065 0.0072 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0238 0.1663 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0097 0.0369 0.0874
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1146 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0072 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.1432 0.4054
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Echinococcus multilocularis glycoprotein Antigen 5 0.0065 0.0072 0.0072
Echinococcus multilocularis cathepsin L cysteine protease 0.0383 0.2991 0.2991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.0369 0.0874
Toxoplasma gondii kringle domain-containing protein 0.0066 0.0086 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0421 0.3348 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Echinococcus granulosus cysteine protease 0.0213 0.1432 0.1432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.0369 0.0874
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0213 0.1432 0.1358
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Loa Loa (eye worm) hypothetical protein 0.0116 0.0541 0.0541
Entamoeba histolytica cysteine protease, putative 0.0383 0.2991 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0099 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Loa Loa (eye worm) hypothetical protein 0.0097 0.0369 0.0369
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0097 0.0369 0.0369
Echinococcus multilocularis enteropeptidase 0.0065 0.0072 0.0072
Leishmania major eukaryotic initiation factor 4a, putative 0.0238 0.1663 0.4941
Brugia malayi Trypsin family protein 0.0065 0.0072 0.0072
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0167 0.1014 0.1014
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0129 0.066 0.066
Schistosoma mansoni lipoxygenase 0.0142 0.0786 0.0786
Echinococcus granulosus microtubule associated protein 2 0.0667 0.5599 0.5599
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0167 0.1014 0.1014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0072 0.0072
Giardia lamblia Cathepsin B precursor 0.0421 0.3348 1
Trypanosoma cruzi cysteine peptidase, putative 0.0383 0.2991 0.2931
Onchocerca volvulus Cathepsin L homolog 0.0383 0.2991 1
Echinococcus multilocularis cathepsin b 0.1146 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.1432 0.4054
Plasmodium falciparum serine repeat antigen 3 0.0097 0.0369 0.0977
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0421 0.3348 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0786 0.0786
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0238 0.1663 0.1663
Echinococcus multilocularis calpain A 0.0129 0.066 0.066
Schistosoma mansoni cathepsin s 0.0116 0.0541 0.0541
Echinococcus granulosus eukaryotic initiation factor 4A 0.0238 0.1663 0.1663
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Onchocerca volvulus 0.0383 0.2991 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0065 0.0072 0.0072
Brugia malayi Cathepsin L-like precursor 0.0267 0.1928 0.1928
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0065 0.0072 0.0072
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1146 1 1
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Brugia malayi Pre-SET motif family protein 0.0201 0.1324 0.1324
Onchocerca volvulus 0.0383 0.2991 1
Onchocerca volvulus 0.0383 0.2991 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.0084 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.0369 0.0369
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1146 1 1
Loa Loa (eye worm) hypothetical protein 0.05 0.4073 0.4073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0267 0.1928 0.565
Leishmania major hypothetical protein, conserved 0.0066 0.0086 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Brugia malayi Cathepsin L-like precursor 0.0383 0.2991 0.2991
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.0369 0.0369
Onchocerca volvulus 0.0066 0.0086 0.0045
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0383 0.2991 0.2991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1432 0.413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1146 1 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.1014 0.1014
Echinococcus granulosus cathepsin L cysteine protease 0.0213 0.1432 0.1432
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0383 0.2991 0.2991
Loa Loa (eye worm) hypothetical protein 0.0116 0.0541 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0097 0.0369 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0097 0.0369 0.0874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.0369 0.0874
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0116 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0097 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Onchocerca volvulus 0.0097 0.0369 0.1017
Brugia malayi cathepsin Z-like cysteine proteinase 0.0097 0.0369 0.0369
Leishmania major eukaryotic initiation factor 4a, putative 0.0238 0.1663 0.4941
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0387 0.0387
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0072 0.0072
Echinococcus multilocularis Mastin 0.0065 0.0072 0.0072
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0238 0.1663 0.1203
Echinococcus granulosus cathepsin l cysteine peptidase 0.0383 0.2991 0.2991
Onchocerca volvulus 0.0383 0.2991 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.0369 0.0874
Echinococcus granulosus glycoprotein Antigen 5 0.0065 0.0072 0.0072
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0097 0.0369 0.0977
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1324 0.1324
Toxoplasma gondii cathepsin CPC1 0.0097 0.0369 0.1058
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0238 0.1663 0.4941
Plasmodium falciparum serine repeat antigen 2 0.0097 0.0369 0.0977
Echinococcus granulosus cathepsin L 0.0213 0.1432 0.1432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0065 0.0072 0.0072
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0017 0.0017
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0099 0.0387 0.0387
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0065 0.0072 0.0072
Loa Loa (eye worm) calpain family protein 1 0.0091 0.031 0.031
Loa Loa (eye worm) cysteine protease 0.0383 0.2991 0.2991
Echinococcus multilocularis cysteine protease 0.0383 0.2991 0.2991
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Loa Loa (eye worm) ctsf protein 0.0383 0.2991 0.2991
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1579 0.4581
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Loa Loa (eye worm) hypothetical protein 0.0267 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0123 0.0608 0.0608
Echinococcus granulosus calpain A 0.0129 0.066 0.066
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0369 0.0286
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Echinococcus granulosus cathepsin L 0.0097 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.1146 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0421 0.3348 0.3291
Brugia malayi Kringle domain containing protein 0.0066 0.0086 0.0086
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0786 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Loa Loa (eye worm) cathepsin B 0.0421 0.3348 0.3348
Trypanosoma cruzi cysteine peptidase, putative 0.0383 0.2991 0.2931
Leishmania major cathepsin L-like protease 0.0383 0.2991 0.8928
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0238 0.1663 0.1663
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.1432 0.1432
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0017 0.0017
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0369 0.0286
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0238 0.1663 0.1663
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Entamoeba histolytica cysteine protease, putative 0.0213 0.1432 0.4054
Echinococcus multilocularis cysteine protease 0.0383 0.2991 0.2991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Trypanosoma cruzi cysteine peptidase, putative 0.0213 0.1432 0.1358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Loa Loa (eye worm) hypothetical protein 0.0267 0.1928 0.1928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0267 0.1928 0.565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.3348 0.3348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.0369 0.0874
Echinococcus multilocularis cathepsin L 0.0097 0.0369 0.0369
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0017 0.0017
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0123 0.0608 0.0608
Schistosoma mansoni hypothetical protein 0.0066 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0116 0.0541 0.0541
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0383 0.2991 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0383 0.2991 0.2991
Brugia malayi Cathepsin L-like precursor 0.0383 0.2991 0.2991
Mycobacterium ulcerans hypothetical protein 0.0065 0.0072 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0097 0.0369 0.0977
Brugia malayi Cathepsin L-like cysteine proteinase 0.0267 0.1928 0.1928
Echinococcus granulosus cathepsin l1 0.0383 0.2991 0.2991
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.0369 0.0874
Plasmodium vivax vivapain-3 0.0213 0.1432 0.4635
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.1432 0.4054
Loa Loa (eye worm) calpain family protein 1 0.0123 0.0608 0.0608
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0129 0.066 0.066
Onchocerca volvulus Cathepsin L homolog 0.0383 0.2991 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.0369 0.0874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Brugia malayi Cathepsin L-like precursor 0.0267 0.1928 0.1928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2991 0.8906
Trypanosoma cruzi cruzipain precursor, putative 0.0383 0.2991 0.2931
Onchocerca volvulus 0.0267 0.1928 0.6358
Giardia lamblia Cathepsin B precursor 0.0421 0.3348 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0097 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Loa Loa (eye worm) trypsin family protein 0.0065 0.0072 0.0072
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0097 0.0369 0.0977
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0238 0.1663 0.4933
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0213 0.1432 0.1432
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0097 0.0369 0.0369
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0097 0.0369 0.0369
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0097 0.0369 0.0369
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0097 0.0369 0.0977
Echinococcus granulosus tissue type plasminogen activator 0.0066 0.0086 0.0086
Onchocerca volvulus 0.0229 0.1579 0.5164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2991 0.8137
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0072 0.0072
Echinococcus multilocularis cathepsin b 0.1146 1 1
Brugia malayi eukaryotic initiation factor 4A 0.0238 0.1663 0.1663
Plasmodium vivax vivapain-1 0.0213 0.1432 0.4635
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.0541 0.046
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.1432 0.1432
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0017 0.0017
Brugia malayi Cathepsin L-like precursor 0.0383 0.2991 0.2991
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0097 0.0369 0.0977
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0267 0.1928 0.1859
Schistosoma mansoni cathepsin B (C01 family) 0.0097 0.0369 0.0369
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0238 0.1663 0.1663
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0213 0.1432 0.1432
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.5599 0.5599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Entamoeba histolytica cysteine proteinase, putative 0.0267 0.1928 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0383 0.2991 0.8906
Loa Loa (eye worm) hypothetical protein 0.0065 0.0072 0.0072
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.0369 0.0369
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0238 0.1663 0.4836
Echinococcus multilocularis calpain family protein 1, d 0.0091 0.031 0.031
Entamoeba histolytica cysteine proteinase, putative 0.0383 0.2991 1
Echinococcus granulosus transmembrane protease serine 3 0.0065 0.0072 0.0072
Brugia malayi fibroinase precursor 0.0097 0.0369 0.0369
Plasmodium vivax vivapain-2 0.0383 0.2991 1
Entamoeba histolytica cysteine proteinase 2 0.0213 0.1432 0.4054
Plasmodium falciparum cysteine proteinase falcipain 1 0.0213 0.1432 0.4635

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells ChEMBL. No reference
IC50 (binding) = 0.02 uM Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells ChEMBL. No reference
IC50 (functional) = 0.3 uM Inhibitory activity against peroxidation of rat cardiac membrane liposomes ChEMBL. No reference
Inhibition (functional) = 89 % In vivo inhibitory activity against acetic acid-induced colitis of rat at 10 mg/kg upon peroral administration ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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