Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Nitric-oxide synthase, endothelial | Starlite/ChEMBL | References |
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0045 | 0.2939 | 0.2939 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0045 | 0.2939 | 0.2939 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0059 | 0.4239 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0118 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0045 | 0.2939 | 0.2939 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0118 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0118 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0118 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0118 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0105 | 0.87 | 0.8159 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.006 | 0.4326 | 0.0151 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0045 | 0.2939 | 0.2939 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0118 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0118 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0045 | 0.2939 | 0.2939 |
Trypanosoma cruzi | p450 reductase, putative | 0.0118 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0105 | 0.87 | 0.87 |
Chlamydia trachomatis | sulfite reductase | 0.0073 | 0.5626 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0073 | 0.5626 | 0.2407 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0105 | 0.87 | 0.8159 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0073 | 0.5626 | 0.5626 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0118 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0045 | 0.2939 | 0.2939 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0059 | 0.4239 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0105 | 0.87 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0073 | 0.5626 | 0.5626 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0118 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0118 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0045 | 0.2939 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0105 | 0.87 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0118 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.056 uM | Binding affinity to recombinant rat neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Ki (binding) | = 0.359 uM | Binding affinity to recombinant human neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Ki (binding) | = 1.9 uM | Binding affinity to recombinant mouse macrophage inducible NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Ki (binding) | = 4 uM | Binding affinity to recombinant bovine endothelial NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.