Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0073 | 0.5626 | 0.5626 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0118 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0118 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0118 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0105 | 0.87 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0045 | 0.2939 | 0.2939 |
Brugia malayi | flavodoxin family protein | 0.0045 | 0.2939 | 0.2939 |
Leishmania major | cytochrome P450 reductase, putative | 0.0105 | 0.87 | 0.87 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0045 | 0.2939 | 0.2939 |
Treponema pallidum | flavodoxin | 0.0045 | 0.2939 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0073 | 0.5626 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0073 | 0.5626 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0118 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0105 | 0.87 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0059 | 0.4239 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0105 | 0.87 | 0.8159 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0118 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0118 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0118 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0118 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0045 | 0.2939 | 0.2939 |
Brugia malayi | FAD binding domain containing protein | 0.0118 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0118 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0118 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.006 | 0.4326 | 0.0151 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0118 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0118 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0105 | 0.87 | 0.8159 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0118 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0073 | 0.5626 | 0.5626 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0045 | 0.2939 | 0.2939 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0045 | 0.2939 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0059 | 0.4239 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.15 uM | Binding affinity to recombinant rat neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Ki (binding) | = 0.873 uM | Binding affinity to recombinant human neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Ki (binding) | = 3 uM | Binding affinity to recombinant mouse macrophage inducible NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Ki (binding) | = 40 uM | Binding affinity to recombinant bovine endothelial NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay | ChEMBL. | 25489882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.