TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.315 | Formula: C19H15F3O4
H donors: 0 H acceptors: 1 LogP: 4.38 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)c2c(c1)oc(c(c2=O)C)c1ccc(cc1)C(F)(F)F
InChi: 1S/C19H15F3O4/c1-10-17(23)16-14(25-3)8-13(24-2)9-15(16)26-18(10)11-4-6-12(7-5-11)19(20,21)22/h4-9H,1-3H3
InChiKey: VCWDSTDYHPUVKY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Tubulin gamma chain	0.0293	0.3935	0.3935
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.1258	0.1258
Schistosoma mansoni	tubulin subunit gamma	0.0293	0.3935	0.3935
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Loa Loa (eye worm)	BEN-1 protein	0.0549	1	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Leishmania major	beta tubulin	0.0549	1	1
Toxoplasma gondii	beta-tubulin, putative	0.0549	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0405	0.6589	0.6589
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0239	0.2654	0.2654
Echinococcus multilocularis	tubulin alpha 3 chain	0.0405	0.6589	0.6589
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0405	0.6589	0.6589
Trypanosoma brucei	alpha tubulin	0.0405	0.6589	0.6589
Trypanosoma cruzi	beta tubulin, putative	0.0549	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0405	0.6589	0.6589
Echinococcus granulosus	tubulin beta 1 chain	0.0549	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0405	0.6589	0.6589
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Trypanosoma cruzi	epsilon tubulin, putative	0.0293	0.3935	0.3935
Echinococcus multilocularis	tubulin subunit TubB	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Schistosoma mansoni	tubulin subunit beta	0.0549	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0405	0.6589	0.6589
Trypanosoma brucei	beta tubulin	0.0549	1	1
Leishmania major	beta tubulin	0.0549	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.1258	0.1258
Brugia malayi	Tubulin alpha chain	0.0405	0.6589	0.6589
Echinococcus multilocularis	Tubulin beta 2C chain	0.0549	1	1
Leishmania major	beta tubulin	0.0549	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0405	0.6589	0.6589
Loa Loa (eye worm)	tubulin beta-4 chain	0.0549	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0549	1	1
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Giardia lamblia	Beta tubulin	0.0549	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0549	1	1
Echinococcus granulosus	beta tubulin	0.0549	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0293	0.3935	0.3935
Schistosoma mansoni	tubulin subunit beta	0.0549	1	1
Schistosoma mansoni	tubulin subunit epsilon	0.0293	0.3935	0.3935
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.014	0.0304	0.0304
Leishmania major	beta tubulin	0.0549	1	1
Onchocerca volvulus		0.0166	0.0915	0.5
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Echinococcus multilocularis	Tubulin beta 2C chain	0.0549	1	1
Trichomonas vaginalis	tubulin, putative	0.0166	0.0915	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0405	0.6589	0.6589
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus multilocularis	tubulin alpha 1C chain	0.0405	0.6589	0.6589
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.014	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2654	0.2654
Echinococcus multilocularis	tubulin subunit beta	0.0549	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0293	0.3935	0.3935
Trichomonas vaginalis	tubulin gamma chain, putative	0.0293	0.3935	0.3935
Echinococcus multilocularis	tubulin beta 1 chain	0.0549	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0405	0.6589	0.6589
Echinococcus granulosus	alpha tubulin	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Trypanosoma brucei	alpha tubulin	0.0405	0.6589	0.6589
Trypanosoma brucei	epsilon tubulin	0.0293	0.3935	0.3935
Plasmodium vivax	tubulin beta chain, putative	0.0549	1	1
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Echinococcus granulosus	Tubulin alpha 1 chain	0.0405	0.6589	0.6589
Schistosoma mansoni	tubulin subunit beta	0.0549	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0405	0.6589	0.6589
Trypanosoma brucei	beta tubulin	0.0549	1	1
Trichomonas vaginalis	tubulin, putative	0.0549	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.0405	0.6589	0.6589
Schistosoma mansoni	alpha tubulin	0.0405	0.6589	0.6589
Echinococcus granulosus	tubulin gamma 1 chain	0.0293	0.3935	0.3935
Echinococcus multilocularis	beta tubulin	0.0549	1	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus granulosus	tubulin alpha	0.0293	0.3935	0.3935
Schistosoma mansoni	tubulin subunit beta	0.0549	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0549	1	1
Treponema pallidum	cell division protein FtsZ	0.0127	0	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus multilocularis	tubulin gamma 1 chain	0.0293	0.3935	0.3935
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.014	0.0304	0.0304
Leishmania major	beta tubulin	0.0549	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0549	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0293	0.3935	0.3935
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0405	0.6589	0.6589
Trypanosoma cruzi	tubulin gamma chain	0.0293	0.3935	0.3935
Leishmania major	beta tubulin	0.0549	1	1
Loa Loa (eye worm)	beta-tubulin	0.0549	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0549	1	1
Plasmodium falciparum	alpha tubulin 1	0.0405	0.6589	0.6589
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Leishmania major	beta tubulin	0.0549	1	1
Trypanosoma brucei	beta tubulin	0.0293	0.3935	0.3935
Plasmodium falciparum	alpha tubulin 2	0.0405	0.6589	0.6589
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0206	0.1858	0.1858
Giardia lamblia	Alpha-tubulin	0.0405	0.6589	0.6589
Echinococcus granulosus	Tubulin beta 2C chain	0.0549	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0549	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0127	0	0.5
Trypanosoma brucei	beta tubulin	0.0549	1	1
Echinococcus granulosus	tubulin alpha chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.1858	0.1858
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus granulosus	tubulin alpha chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus multilocularis	Tubulin beta 2C chain	0.0549	1	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0206	0.1858	0.1858
Leishmania major	beta tubulin	0.0549	1	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus multilocularis	tubulin alpha 3 chain	0.0405	0.6589	0.6589
Plasmodium vivax	tubulin gamma chain, putative	0.0293	0.3935	0.3935
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Trypanosoma brucei	tubulin gamma chain	0.0293	0.3935	0.3935
Echinococcus granulosus	Tubulin beta 2C chain	0.0549	1	1
Leishmania major	beta tubulin	0.0549	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0549	1	1
Plasmodium falciparum	tubulin gamma chain	0.0293	0.3935	0.3935
Echinococcus multilocularis	Tubulin beta 2C chain	0.0549	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0405	0.6589	0.6589
Loa Loa (eye worm)	tubulin beta-1 chain	0.0549	1	1
Echinococcus multilocularis	tubulin alpha	0.0293	0.3935	0.3935
Loa Loa (eye worm)	tubulin alpha 2	0.0278	0.357	0.357
Trichomonas vaginalis	tubulin alpha chain, putative	0.0293	0.3935	0.3935
Brugia malayi	Tubulin alpha-2 chain	0.0405	0.6589	0.6589
Plasmodium falciparum	tubulin epsilon chain, putative	0.0293	0.3935	0.3935
Echinococcus granulosus	Tubulin beta 2C chain	0.0549	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0405	0.6589	0.6589
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0127	0	0.5
Trichomonas vaginalis	tubulin alpha chain, putative	0.0166	0.0915	0.0915
Trichomonas vaginalis	tubulin beta chain, putative	0.0405	0.6589	0.6589
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus multilocularis	tubulin alpha chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Brugia malayi	alpha-tubulin	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Loa Loa (eye worm)	tubulin alpha chain	0.0405	0.6589	0.6589
Schistosoma mansoni	tubulin subunit beta	0.0549	1	1
Giardia lamblia	Alpha-tubulin	0.0405	0.6589	0.6589
Entamoeba histolytica	tubulin family protein	0.0549	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0405	0.6589	0.6589
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Echinococcus multilocularis	peroxisome assembly protein 26	0.0405	0.6589	0.6589
Trichomonas vaginalis	tubulin alpha chain, putative	0.0549	1	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0206	0.1858	0.1858
Trypanosoma brucei	epsilon tubulin	0.0293	0.3935	0.3935
Plasmodium vivax	tubulin alpha chain, putative	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0405	0.6589	0.6589
Trypanosoma brucei	alpha tubulin, putative	0.0166	0.0915	0.0915
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Loa Loa (eye worm)	hypothetical protein	0.0278	0.357	0.357
Trypanosoma brucei	beta tubulin	0.0549	1	1
Schistosoma mansoni	alpha tubulin	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0278	0.357	0.357
Echinococcus granulosus	tubulin alpha 3 chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	tubulin gamma chain, putative	0.0549	1	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0206	0.1858	0.1858
Mycobacterium ulcerans	cell division protein FtsZ	0.0127	0	0.5
Giardia lamblia	Beta tubulin	0.0549	1	1
Echinococcus multilocularis	hypothetical protein	0.0405	0.6589	0.6589
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0206	0.1858	0.1858
Echinococcus granulosus	tubulin alpha 1C chain	0.0405	0.6589	0.6589
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.1258	0.1258
Trypanosoma cruzi	epsilon tubulin, putative	0.0293	0.3935	0.3935
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Entamoeba histolytica	tubulin family protein	0.0549	1	1
Trypanosoma brucei	alpha tubulin	0.0405	0.6589	0.6589
Leishmania major	beta tubulin	0.0549	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0549	1	1
Leishmania major	epsilon tubulin, putative	0.0293	0.3935	0.3935
Echinococcus multilocularis	beta tubulin	0.0549	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0405	0.6589	0.6589
Trichomonas vaginalis	tubulin beta chain, putative	0.0405	0.6589	0.6589
Echinococcus granulosus	Tubulin alpha 1 chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	tubulin, putative	0.0166	0.0915	0.0915
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0549	1	1
Leishmania major	beta tubulin	0.0549	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0405	0.6589	0.6589
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0206	0.1858	0.1858
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0206	0.1858	0.1858
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Leishmania major	beta tubulin	0.0549	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0405	0.6589	0.6589
Loa Loa (eye worm)	alpha-tubulin	0.0405	0.6589	0.6589
Echinococcus granulosus	tubulin alpha chain	0.0405	0.6589	0.6589
Brugia malayi	tubulin alpha chain - mouse	0.0405	0.6589	0.6589
Trypanosoma brucei	alpha tubulin	0.0405	0.6589	0.6589
Plasmodium falciparum	tubulin beta chain	0.0549	1	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0405	0.6589	0.6589
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	tubulin alpha chain, putative	0.0166	0.0915	0.0915
Echinococcus multilocularis	tubulin epsilon chain	0.0293	0.3935	0.3935
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0127	0	0.5
Giardia lamblia	Gamma tubulin	0.0293	0.3935	0.3935
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0278	0.357	0.357
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Echinococcus multilocularis	Tubulin beta 2C chain	0.0549	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0166	0.0915	0.0915
Toxoplasma gondii	alpha-tubulin I, putative	0.0405	0.6589	0.6589
Brugia malayi	tubulin alpha-2 chain	0.0405	0.6589	0.6589
Giardia lamblia	Beta tubulin	0.0549	1	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0206	0.1858	0.1858
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0405	0.6589	0.6589
Toxoplasma gondii	hypothetical protein	0.018	0.1258	0.1258
Trichomonas vaginalis	tubulin beta chain, putative	0.0405	0.6589	0.6589
Echinococcus multilocularis	tubulin alpha chain	0.0405	0.6589	0.6589
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0405	0.6589	0.6589
Echinococcus granulosus	tubulin subunit TubB	0.0405	0.6589	0.6589
Entamoeba histolytica	tubulin alpha-1 chain	0.0405	0.6589	0.4376
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Schistosoma mansoni	tubulin subunit beta	0.0549	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0549	1	1
Brugia malayi	beta-tubulin, identical	0.0549	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0405	0.6589	0.4376
Echinococcus granulosus	Tubulin beta 2C chain	0.0549	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0166	0.0915	0.0915
Leishmania major	gamma-tubulin	0.0293	0.3935	0.3935
Trichomonas vaginalis	tubulin beta chain, putative	0.0166	0.0915	0.0915
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	tubulin beta chain, putative	0.0405	0.6589	0.6589
Toxoplasma gondii	beta tubulin	0.0549	1	1
Echinococcus granulosus	tubulin subunit beta	0.0549	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Brugia malayi	Tubulin beta chain	0.0166	0.0915	0.0915
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0239	0.2654	0.2654
Echinococcus granulosus	Tubulin alpha 1 chain	0.0405	0.6589	0.6589
Schistosoma mansoni	alpha tubulin	0.0405	0.6589	0.6589
Brugia malayi	Tubulin alpha-2 chain	0.0405	0.6589	0.6589
Echinococcus granulosus	tubulin alpha chain	0.0405	0.6589	0.6589
Echinococcus granulosus	beta tubulin	0.0549	1	1
Leishmania major	alpha tubulin	0.0405	0.6589	0.6589
Echinococcus granulosus	tubulin alpha chain	0.0405	0.6589	0.6589
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Trypanosoma brucei	epsilon tubulin	0.0293	0.3935	0.3935
Schistosoma mansoni	tubulin subunit alpha	0.0405	0.6589	0.6589
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0206	0.1858	0.1858
Trichomonas vaginalis	tubulin gamma chain, putative	0.0293	0.3935	0.3935
Echinococcus granulosus	tubulin epsilon chain	0.0293	0.3935	0.3935
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0206	0.1858	0.1858
Loa Loa (eye worm)	tubulin alpha 2	0.0278	0.357	0.357

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 10.08 uM	In vitro anti-cancer activity against SGC-7901 cell	ChEMBL.	14505641
IC50 (functional)	= 10.08 uM	In vitro anti-cancer activity against SGC-7901 cell	ChEMBL.	14505641

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	14505641

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 202070