Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cyclophilin Ovcyp-2 | 0.0046 | 1 | 1 |
Toxoplasma gondii | cyclophilin 1, putative | 0.0046 | 1 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0046 | 1 | 1 |
Trypanosoma cruzi | cyclophilin, putative | 0.0046 | 1 | 0.5 |
Trypanosoma brucei | cyclophilin a | 0.0046 | 1 | 0.5 |
Onchocerca volvulus | 0.0046 | 1 | 1 | |
Onchocerca volvulus | 0.0046 | 1 | 1 | |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0046 | 1 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0046 | 1 | 0.5 |
Brugia malayi | cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3 | 0.0046 | 1 | 1 |
Plasmodium vivax | cyclophilin, putative | 0.0046 | 1 | 0.5 |
Schistosoma mansoni | cyclophilin | 0.0046 | 1 | 1 |
Trypanosoma brucei | cyclophilin, putative | 0.0046 | 1 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0046 | 1 | 1 |
Trichomonas vaginalis | peptidyl-prolyl cis-trans isomerase A, ppia, putative | 0.0046 | 1 | 0.5 |
Loa Loa (eye worm) | cyclophilin-type peptidyl-prolyl cis-trans isomerase-2 | 0.0046 | 1 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase | 0.0046 | 1 | 0.5 |
Toxoplasma gondii | cyclophilin precursor | 0.0046 | 1 | 0.5 |
Trypanosoma cruzi | rotamase, putative | 0.0046 | 1 | 0.5 |
Plasmodium vivax | unspecified product | 0.0046 | 1 | 0.5 |
Trypanosoma cruzi | cyclophilin type peptidyl-prolyl cis-trans isomerase | 0.0046 | 1 | 0.5 |
Leishmania major | cyclophilin a | 0.0046 | 1 | 0.5 |
Leishmania major | cyclophilin 4, putative | 0.0046 | 1 | 0.5 |
Trypanosoma cruzi | 21 kDa cyclophilin, putative | 0.0046 | 1 | 0.5 |
Leishmania major | cyclophilin 11, putative | 0.0046 | 1 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0046 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 13 % | Tested for the binding affinity, for displacement of [125I]-AB-MECA in membranes of CHO cells stably transfected with the rat A3-cDNA at the 3*10e-5 concentration (M) | ChEMBL. | 7932565 |
Inhibition (binding) | = 13 % | Tested for the binding affinity, for displacement of [125I]-AB-MECA in membranes of CHO cells stably transfected with the rat A3-cDNA at the 3*10e-5 concentration (M) | ChEMBL. | 7932565 |
Ki (binding) | = 5.27 uM | Displacement of [3H]-PIA from adenosine A1 receptors of rat brain membrane | ChEMBL. | 7932565 |
Ki (binding) | = 5.27 uM | Displacement of [3H]-PIA from adenosine A1 receptors of rat brain membrane | ChEMBL. | 7932565 |
Ki (binding) | = 20 uM | Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane | ChEMBL. | 7932565 |
Ki (binding) | = 20 uM | Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane | ChEMBL. | 7932565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.