Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.7877 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.7877 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.615 | 0.7585 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7877 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7877 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7877 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.7877 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7877 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.153 | 0.1122 | 0.1122 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7877 | 1 | 0.5 |
Onchocerca volvulus | 0.153 | 0.1122 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0728 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.615 | 0.7585 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.615 | 0.7585 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7877 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.615 | 0.7585 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.615 | 0.7585 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.615 | 0.7585 | 1 |
Brugia malayi | thymidylate synthase | 0.153 | 0.1122 | 0.1122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 270000 nM | Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | ChEMBL. | 8230137 |
Ki (binding) | = 270000 nM | Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | ChEMBL. | 8230137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.