Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1859 | 0.1192 | 0.1192 |
Schistosoma mansoni | dihydrofolate reductase | 0.9062 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.9062 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.9062 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0884 | 0 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.9062 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.1859 | 0.1192 | 0.1192 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7225 | 0.7754 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7225 | 0.7754 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.9062 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7225 | 0.7754 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.9062 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7225 | 0.7754 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.9062 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7225 | 0.7754 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.9062 | 1 | 0.5 |
Onchocerca volvulus | 0.1859 | 0.1192 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7225 | 0.7754 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.9062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antiviral activity against human cytomegalovirus by plaque reduction assay | ChEMBL. | 8784444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.