Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.1292 | 0.174 | 0.174 |
Plasmodium falciparum | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0074 | 0.0086 | 0.012 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1292 | 0.174 | 0.1736 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.0001 | 0.0002 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0004 | 0.0004 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0071 | 0.0082 | 0.0082 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7372 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0021 | 0.0261 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0077 | 0.0077 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0014 | 0.0004 | 0.0004 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.024 | 0.0311 | 0.0311 |
Toxoplasma gondii | glutamine-dependent NAD(+) synthetase protein, putative | 0.008 | 0.0093 | 0.0131 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.0013 | 0.0013 |
Echinococcus granulosus | Chromo domain | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0018 | 0.001 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0028 | 0.0028 |
Schistosoma mansoni | netrin receptor unc5 | 0.0014 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0036 | 0.0036 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.0001 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0036 | 0.0445 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0048 | 0.005 | 0.005 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | GMP synthase | 0.0032 | 0.0028 | 0.0027 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.004 | 0.0492 |
Echinococcus granulosus | GMP synthase glutamine hydrolyzing | 0.0032 | 0.0028 | 0.0028 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Brugia malayi | Associated with TFs and helicases family protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Brugia malayi | CHD4 protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0011 | 0.00000043255 | 0.0000000027474 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0004 | 0.0004 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0014 | 0.0004 | 0.0006 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.0297 | 0.3626 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Onchocerca volvulus | 0.003 | 0.0025 | 0.0146 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7372 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0004 | 0.0026 | |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0021 | 0.0261 |
Entamoeba histolytica | NAD synthetase, putative | 0.008 | 0.0093 | 1 |
Brugia malayi | Death domain containing protein | 0.0014 | 0.0004 | 0.0004 |
Schistosoma mansoni | GMP synthetase | 0.0032 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0051 | 0.0051 |
Onchocerca volvulus | Putative hydroxypyruvate isomerase | 0.002 | 0.0012 | 0.0066 |
Echinococcus granulosus | geminin | 0.0336 | 0.0442 | 0.0442 |
Leishmania major | GMP synthase, putative,glutamine amidotransferase, putative | 0.0032 | 0.0028 | 0.004 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0014 | 0.0004 | 0.0004 |
Brugia malayi | Hypothetical 29.7 kDa protein C05D11.5 in chromosome III | 0.002 | 0.0012 | 0.0012 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Onchocerca volvulus | 0.004 | 0.0039 | 0.0226 | |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0058 | 0.0064 | 0.009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Mycobacterium ulcerans | epimerase | 0.002 | 0.0012 | 0.001 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.008 | 0.0093 | 0.0131 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.008 | 0.0093 | 0.0131 |
Brugia malayi | hypothetical protein | 0.024 | 0.0311 | 0.0311 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.008 | 0.0093 | 0.0131 |
Treponema pallidum | NAD synthetase | 0.008 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0614 | 0.082 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.004 | 0.0232 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0024 | 0.0024 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5267 | 0.7141 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Mycobacterium leprae | PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) | 0.008 | 0.0093 | 0.0082 |
Mycobacterium ulcerans | sugar phosphate isomerases/epimerases | 0.002 | 0.0012 | 0.001 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.0013 | 0.016 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0051 | 0.0051 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0024 | 0.0024 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0014 | 0.0004 | 0.0004 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.0013 | 0.0013 |
Trypanosoma brucei | NAD+ synthase, putative | 0.008 | 0.0093 | 0.0131 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0014 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.0311 | 0.0311 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus multilocularis | geminin | 0.0336 | 0.0442 | 0.0442 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0012 | 0.0007 |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0011 | 0.00000042981 | 0.0000000000067055 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0024 | 0.0024 |
Echinococcus granulosus | death domain containing protein | 0.0014 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | thymidylate synthase | 0.1292 | 0.174 | 0.1739 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0016 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0001 | 0.0001 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) | 0.0074 | 0.0086 | 0.0082 |
Echinococcus multilocularis | GMP synthase (glutamine hydrolyzing) | 0.0032 | 0.0028 | 0.0028 |
Trichomonas vaginalis | chromobox protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Brugia malayi | SET domain containing protein | 0.0012 | 0.0001 | 0.0001 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0001 | 0.0002 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0014 | 0.0004 | 0.0006 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0023 | 0.0023 |
Plasmodium falciparum | GMP synthase [glutamine-hydrolyzing] | 0.0032 | 0.0028 | 0.004 |
Mycobacterium ulcerans | NAD synthetase | 0.008 | 0.0093 | 0.0092 |
Plasmodium vivax | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0074 | 0.0086 | 0.012 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Schistosoma mansoni | dihydrofolate reductase | 0.7372 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0001 | 0.0001 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.004 | 0.0039 | 0.0039 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0004 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.0077 | 0.0077 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.0013 | 0.0013 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.0077 | 0.0077 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0614 | 0.082 | 0.1148 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0036 | 0.0036 |
Trypanosoma brucei | pteridine reductase 1 | 0.0189 | 0.0241 | 0.0338 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0036 | 0.021 |
Leishmania major | pteridine reductase 1 | 0.0195 | 0.025 | 0.035 |
Onchocerca volvulus | 0.1292 | 0.174 | 1 | |
Toxoplasma gondii | bifunctional GMP synthase/glutamine amidotransferase protein | 0.0032 | 0.0028 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0086 | 0.0086 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0014 | 0.0004 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0012 | 0.0012 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus granulosus | thymidylate synthase | 0.1292 | 0.174 | 0.174 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.0297 | 0.0297 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0024 | 0.0024 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0071 | 0.0082 | 0.0082 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0014 | 0.0004 | 0.0006 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0014 | 0.0004 | 0.0006 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1292 | 0.174 | 0.174 |
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0.0012 | 0.001 |
Onchocerca volvulus | 0.0011 | 0.00000043255 | 0.000000015792 | |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.0442 | 0.0442 |
Trichomonas vaginalis | Heterochromatin protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.0064 | 0.0064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Trichomonas vaginalis | chromobox protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0004 | 0.0004 |
Trypanosoma brucei | GMP synthase [glutamine-hydrolysing] | 0.0032 | 0.0028 | 0.004 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0077 | 0.0077 |
Plasmodium vivax | GMP synthetase, putative | 0.0032 | 0.0028 | 0.004 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.004 | 0.0492 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1292 | 0.174 | 0.173 |
Brugia malayi | GMP synthase | 0.0032 | 0.0028 | 0.0028 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.0013 | 0.0013 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0001 | 0.0001 |
Brugia malayi | Dihydrofolate reductase | 0.7372 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7372 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7372 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7372 | 1 | 1 |
Plasmodium falciparum | chromodomain-helicase-DNA-binding protein 1 homolog, putative | 0.0011 | 0.00000042981 | 0.0000000000067055 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0051 | 0.0051 |
Onchocerca volvulus | Netrin receptor homolog | 0.0014 | 0.0004 | 0.0023 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.0067 | 0.0067 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0014 | 0.0004 | 0.0004 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0077 | 0.0077 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0077 | 0.0937 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0036 | 0.0445 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0001 | 0.0001 |
Brugia malayi | DNA-(Apurinic or apyrimidinic site) lyase | 0.0074 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5267 | 0.7141 | 1 |
Leishmania major | NAD synthase, putative | 0.008 | 0.0093 | 0.0131 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | thymidylate synthase | 0.1292 | 0.174 | 0.174 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0001 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.0442 | 0.0442 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0077 | 0.0937 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0001 | 0.0001 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.0064 | 0.0063 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.008 | 0.0093 | 0.0093 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0077 | 0.0077 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0004 | 0.0004 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0014 | 0.0004 | 0.0004 |
Toxoplasma gondii | endonuclease IV APN | 0.0074 | 0.0086 | 0.012 |
Brugia malayi | Type III restriction enzyme, res subunit family protein | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Echinococcus granulosus | Chromobox protein 3 | 0.0011 | 0.00000043255 | 0.0000000027474 |
Brugia malayi | hypothetical protein | 0.0614 | 0.082 | 0.082 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.0297 | 0.0297 |
Leishmania major | oxidoreductase-like protein | 0.0014 | 0.0004 | 0.0006 |
Onchocerca volvulus | 0.0049 | 0.0051 | 0.0296 | |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0014 | 0.0004 | 0.0004 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0259 | 0.0259 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0014 | 0.0004 | 0.0003 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.0013 | 0.016 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0077 | 0.0077 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5267 | 0.7141 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0011 | 0.00000042981 | 0.0000000000067055 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0004 | 0.0004 |
Trichomonas vaginalis | chromobox protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Trichomonas vaginalis | nh(3)-dependent NAD(+) synthetase, putative | 0.008 | 0.0093 | 0.1138 |
Trichomonas vaginalis | hypothetical protein | 0.0011 | 0.00000042981 | 0.0000052431 |
Echinococcus multilocularis | Chromo domain | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Brugia malayi | Uncoordinated protein 44 | 0.0014 | 0.0004 | 0.0004 |
Echinococcus granulosus | dihydrofolate reductase | 0.7372 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0259 | 0.0259 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.008 | 0.0093 | 0.0131 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0024 | 0.0034 |
Giardia lamblia | NH3-dependent NAD+ synthetase | 0.008 | 0.0093 | 0.5 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0011 | 0.00000042981 | 0.0000000000047884 |
Onchocerca volvulus | 0.023 | 0.0297 | 0.171 | |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0014 | 0.0004 | 0.0003 |
Mycobacterium tuberculosis | Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) | 0.008 | 0.0093 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0004 | 0.0004 |
Echinococcus multilocularis | thymidylate synthase | 0.1292 | 0.174 | 0.174 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0024 | 0.0024 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0011 | 0.00000042981 | 0.0000052431 |
Mycobacterium leprae | PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) | 0.0074 | 0.0086 | 0.0075 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0024 | 0.0034 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0024 | 0.0024 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5267 | 0.7141 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5267 | 0.7141 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0614 | 0.082 | 0.0816 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0058 | 0.0064 | 0.006 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7372 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0014 | 0.0004 | 0.0003 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5267 | 0.7141 | 1 |
Mycobacterium ulcerans | endonuclease IV | 0.0074 | 0.0086 | 0.0085 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.024 | 0.0311 | 0.0311 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.0064 | 0.0063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 80 uM | Ability to inhibit Cyclin-dependent kinase 5-p35. | ChEMBL. | 14505655 |
IC50 (binding) | = 80 uM | Ability to inhibit Cyclin-dependent kinase 5-p35. | ChEMBL. | 14505655 |
IC50 (binding) | > 100 uM | Ability to inhibit cyclin-dependent kinase 2-cyclin A. | ChEMBL. | 14505655 |
IC50 (binding) | > 100 uM | Ability to inhibit cyclin-dependent kinase 2-cyclin A. | ChEMBL. | 14505655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.