Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0021 | 0.0588 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.2559 | 0.2559 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0011 | 0.0032 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0179 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0011 | 0.0032 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2559 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0011 | 0.0032 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2559 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.2559 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0011 | 0.0032 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.2559 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0021 | 0.0588 | 0.2299 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0011 | 0.0032 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.2559 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.2559 | 0.2559 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.2559 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.2559 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.2559 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.2559 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0011 | 0.0032 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0032 | 0.0032 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.2559 | 1 |
Echinococcus multilocularis | 0.0011 | 0.0032 | 0.0032 | |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.0588 | 0.2299 |
Trypanosoma brucei | cytochrome P450, putative | 0.0021 | 0.0588 | 0.2201 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0011 | 0.0032 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.2559 | 0.2559 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.1243 | 0.4858 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2559 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0.0588 | 0.2201 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0011 | 0.0032 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0021 | 0.0588 | 0.2299 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.2559 | 0.2559 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0011 | 0.0032 | 0.0032 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0.0588 | 0.2201 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.2559 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.0588 | 0.2299 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0011 | 0.0032 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0011 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0011 | 0.0032 | 0.5 |
Echinococcus multilocularis | geminin | 0.0179 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0011 | 0.0032 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0011 | 0.0032 | 0.0126 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0011 | 0.0032 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.2559 | 1 |
Brugia malayi | cytochrome P450 | 0.0011 | 0.0032 | 0.0126 |
Leishmania major | cytochrome p450-like protein | 0.0021 | 0.0588 | 0.2201 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0011 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0011 | 0.0032 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0021 | 0.0588 | 0.2299 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.2559 | 0.2559 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.2559 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.1243 | 0.4858 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.2559 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2559 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0032 | 0.0126 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC50 (functional) | = 143 uM | Anti-influenza virus activity was evaluated in Madin-Darby canine kidney (MDCK) cells against influenza A H2N2 strain (A2 Japan/305/57) | ChEMBL. | 10617092 |
MIC50 (functional) | > 143 uM | Anti-influenza virus activity was evaluated in Madin-Darby canine kidney (MDCK) cells against influenza A H3N2 (X31) | ChEMBL. | 10617092 |
MIC50 (functional) | > 143 uM | Anti-influenza virus activity was evaluated in Madin-Darby canine kidney (MDCK) cells against influenza B (Hong Kong/5/72) | ChEMBL. | 10617092 |
MTC50 (functional) | = 977 uM | Concentration required to reduce the viability of MDCK cells | ChEMBL. | 10617092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.