Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0664 | 0.051 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0103 | 0.2403 | 0.2403 |
Schistosoma mansoni | aldo-keto reductase | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0664 | 0.051 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0253 | 0.6902 | 0.5922 |
Leishmania major | prostaglandin f synthase, putative | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.2403 | 0.2403 |
Entamoeba histolytica | aldose reductase, putative | 0.0356 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.2851 | 0.2733 |
Loa Loa (eye worm) | oxidoreductase | 0.0356 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0356 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0356 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0103 | 0.2403 | 0.2403 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0356 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0356 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0356 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0103 | 0.2403 | 0.2278 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0103 | 0.2403 | 0.2278 |
Brugia malayi | NADH-dependent xylose reductase | 0.0103 | 0.2403 | 0.2278 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0664 | 0.051 |
Echinococcus multilocularis | aldehyde reductase | 0.0253 | 0.6902 | 0.6851 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0103 | 0.2403 | 0.2278 |
Echinococcus granulosus | aldehyde reductase | 0.0253 | 0.6902 | 0.6851 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.2851 | 0.2733 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0103 | 0.2403 | 0.2278 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0356 | 1 | 1 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0103 | 0.2403 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0103 | 0.2403 | 0.2278 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0304 | 0.8446 | 0.8421 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2403 | 0.2403 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0664 | 0.051 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0356 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0103 | 0.2403 | 0.2403 |
Echinococcus granulosus | aldo keto reductase | 0.0356 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0664 | 0.051 |
Echinococcus granulosus | aldo keto reductase | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0103 | 0.2403 | 0.2403 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0103 | 0.2403 | 0.2278 |
Leishmania major | aldo-keto reductase-like protein | 0.0356 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0356 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0304 | 0.8446 | 0.8421 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0103 | 0.2403 | 0.2278 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0103 | 0.2403 | 0.2278 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2403 | 0.2403 |
Schistosoma mansoni | aldo-keto reductase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0664 | 0.051 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0356 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0356 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0356 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0664 | 0.051 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0356 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0356 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.1741 | 0.1605 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0664 | 0.051 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0103 | 0.2403 | 0.2403 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.2851 | 0.2733 |
Echinococcus multilocularis | aldo keto reductase | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0356 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0103 | 0.2403 | 0.2278 |
Echinococcus granulosus | snurportin 1 | 0.0304 | 0.8446 | 0.8421 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0103 | 0.2403 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0356 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0103 | 0.2403 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.8446 | 0.8421 |
Giardia lamblia | Aldose reductase | 0.0356 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0356 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0103 | 0.2403 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0664 | 0.051 |
Echinococcus granulosus | aldo keto reductase | 0.0356 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0356 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0103 | 0.2403 | 0.2278 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2403 | 0.2403 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0356 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0356 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0356 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 105 % | Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 12.5 mg/kg | ChEMBL. | 3806588 |
T/C (functional) | = 105 % | Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 12.5 mg/kg | ChEMBL. | 3806588 |
T/C (functional) | = 108 % | Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 50 mg/kg | ChEMBL. | 3806588 |
T/C (functional) | = 108 % | Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 50 mg/kg | ChEMBL. | 3806588 |
T/C (functional) | = 125 % | Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 25 mg/kg | ChEMBL. | 3806588 |
T/C (functional) | = 125 % | Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 25 mg/kg | ChEMBL. | 3806588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.