Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | intercellular adhesion molecule 1 | Starlite/ChEMBL | References |
Homo sapiens | selectin E | Starlite/ChEMBL | References |
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Homo sapiens | vascular cell adhesion molecule 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | c4b binding protein beta chain | selectin E | 610 aa | 551 aa | 22.1 % |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0128 | 0.0128 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.1979 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.085 | 0.0836 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0026 | 0.1979 | 0.1966 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.1979 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.1979 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.1979 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1256 | 0.1242 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.1979 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0026 | 0.1979 | 0.1966 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0022 | 0.1256 | 0.1242 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0128 | 0.0112 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0026 | 0.1979 | 0.1966 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.085 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0128 | 0.0112 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0273 | 0.0257 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0128 | 0.0112 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.1979 | 0.1966 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0026 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Plasmodium falciparum | glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0128 | 0.0128 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0026 | 0.1979 | 0.1966 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0026 | 0.1979 | 0.1966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 115 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 115 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 116 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 116 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.