Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.5396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 1 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0279 | 0.2596 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.5396 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 0.2596 | 0.2596 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 0.2596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.5396 | 0.5396 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 0.2596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1239 | 0.1239 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.5396 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0374 | 0.5396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1239 | 0.1239 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.007 uM | Inhibition of human leukotriene A4 hydrolase (LTA-4). | ChEMBL. | 12139459 |
IC50 (binding) | = 0.007 uM | Inhibition of human leukotriene A4 hydrolase (LTA-4). | ChEMBL. | 12139459 |
IC50 (functional) | = 0.11 uM | Inhibition of human whole blood LTB-4 production (Leukotriene B-4). | ChEMBL. | 12139459 |
IC50 (functional) | = 0.11 uM | Inhibition of human whole blood LTB-4 production (Leukotriene B-4). | ChEMBL. | 12139459 |
Inhibition (functional) | = 98 % | Percentage inhibition of mouse ex vivo whole blood LTB-4 production (Leukotriene B-4) at a concentration of 10 mg/kg. | ChEMBL. | 12139459 |
Inhibition (functional) | = 98 % | Percentage inhibition of mouse ex vivo whole blood LTB-4 production (Leukotriene B-4) at a concentration of 10 mg/kg. | ChEMBL. | 12139459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.