Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.0409 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0032 | 0.067 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0341 | 0.0341 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0033 | 0.0715 | 0.6199 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 0.0409 | 0.7392 |
Onchocerca volvulus | 0.0322 | 1 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0033 | 0.0715 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0033 | 0.0715 | 0.757 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0032 | 0.067 | 0.0341 |
Schistosoma mansoni | DNA helicase recq5 | 0.0022 | 0.0341 | 0.3607 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0033 | 0.0715 | 0.0388 |
Echinococcus granulosus | bloom syndrome protein | 0.0032 | 0.067 | 0.8803 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0553 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0033 | 0.0715 | 0.6199 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0019 | 0.0261 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0553 | 0.5855 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0032 | 0.067 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.0316 | 0.3346 |
Echinococcus multilocularis | bloom syndrome protein | 0.0032 | 0.067 | 0.5456 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0553 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0033 | 0.0715 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0028 | 0.0553 | 0.5673 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0553 | 0.022 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0022 | 0.0341 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0248 | 0.7275 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0341 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0093 | 0.2657 | 0.2398 |
Brugia malayi | hypothetical protein | 0.0159 | 0.4763 | 0.4578 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.0409 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2707 | 0.2707 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0093 | 0.2657 | 0.2657 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0093 | 0.2657 | 0.2657 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.0409 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0553 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0033 | 0.0715 | 0.0715 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0011 | 0.00000000028656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.4763 | 0.4763 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0028 | 0.0553 | 0.3517 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0341 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0022 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | runx1 | 0.004 | 0.0945 | 0.0945 |
Schistosoma mansoni | DNA helicase recq1 | 0.0022 | 0.0341 | 0.3607 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.003 | 0.0602 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.004 | 0.0945 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0032 | 0.067 | 0.067 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0033 | 0.0715 | 0.757 |
Schistosoma mansoni | lozenge | 0.004 | 0.0945 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0033 | 0.0715 | 0.757 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0028 | 0.0553 | 0.5855 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Body weight (functional) | = -8.4 % | Average percent change in body weight of the compound against L1210 leukemia in mice at 10 mg/kg | ChEMBL. | 8246218 |
Body weight (functional) | = -8.4 % | Average percent change in body weight of the compound against L1210 leukemia in mice at 10 mg/kg | ChEMBL. | 8246218 |
Cures (functional) | = 100 % | Compound was tested for percent cures (60-day survivors) in mice at 10 mg/kg | ChEMBL. | 8246218 |
Cures (functional) | = 100 % | Compound was tested for percent cures (60-day survivors) in mice at 10 mg/kg | ChEMBL. | 8246218 |
Rate of decomposition (ADMET) | = 0.3 (nM of drug) min-1 ml-1 | Relative rate of decomposition is the rate of decomposition of acyl compound to that of rate of decomposition of compound | ChEMBL. | 8246218 |
Rate of decomposition (ADMET) | = 2.9 (nM of drug) min-1 ml-1 | Initial rate of decomposition of the compound (1 mM) in 1 mM potassium phosphate buffer | ChEMBL. | 8246218 |
Rate of decomposition (ADMET) | = 8.57 (nM of drug) min-1 ml-1 | Rate of decomposition of the compound in presence of CD-1 mouse serum | ChEMBL. | 8246218 |
Rate of decomposition (ADMET) | = 147 (nM of drug) min-1 ml-1 | Rate of decomposition of the compound in presence of 10 mM glutathione (GSH) | ChEMBL. | 8246218 |
Relative rate of decomposition (ADMET) | = 3 (nM of drug) min-1 ml-1 | Relative rate of decomposition is the rate of decomposition in the presence of 2% serum/rate of hydrolysis in buffer alone. | ChEMBL. | 8246218 |
Relative rate of decomposition (ADMET) | = 50.6 (nM of drug) min-1 ml-1 | Relative rate of decomposition is the rate of decomposition in the presence of 10 mMGSH/rate of decomposition in buffer alone | ChEMBL. | 8246218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.