Detailed information for compound 202882

Basic information

Technical information
  • TDR Targets ID: 202882
  • Name: 2-methyl-9-propan-2-ylcarbazol-3-amine
  • MW: 238.328 | Formula: C16H18N2
  • H donors: 1 H acceptors: 0 LogP: 3.72 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc2c(cc1N)c1c(n2C(C)C)cccc1
  • InChi: 1S/C16H18N2/c1-10(2)18-15-7-5-4-6-12(15)13-9-14(17)11(3)8-16(13)18/h4-10H,17H2,1-3H3
  • InChiKey: QUAFLMHTYSWARL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-isopropyl-2-methyl-carbazol-3-amine
  • 9-isopropyl-2-methyl-3-carbazolamine
  • 2-methyl-9-propan-2-yl-carbazol-3-amine
  • (9-isopropyl-2-methyl-carbazol-3-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni importin beta-1 0.0034 0.0347 0.0347
Echinococcus multilocularis para nitrobenzyl esterase 0.0038 0.0474 0.0474
Plasmodium falciparum importin beta, putative 0.0034 0.0347 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.6006 0.6006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0347 0.0347
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0347 1
Brugia malayi Importin beta-1 subunit 0.0034 0.0347 0.0394
Echinococcus granulosus acetylcholinesterase 0.0224 0.6006 0.6006
Brugia malayi glutaminase DH11.1 0.0319 0.8808 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0038 0.0474 1
Plasmodium vivax importin-beta 2, putative 0.0034 0.0347 1
Trichomonas vaginalis glutaminase, putative 0.0319 0.8808 1
Brugia malayi hypothetical protein 0.0038 0.0474 0.0538
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.7506 0.7506
Echinococcus multilocularis acetylcholinesterase 0.0224 0.6006 0.6006
Mycobacterium ulcerans carboxylesterase, LipT 0.0038 0.0474 0.0538
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0038 0.0474 0.0474
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0347 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0038 0.0474 0.0474
Brugia malayi follicle stimulating hormone receptor 0.0275 0.7506 0.8522
Echinococcus granulosus BC026374 protein S09 family 0.0038 0.0474 0.0474
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0084 0.2408
Echinococcus granulosus para nitrobenzyl esterase 0.0038 0.0474 0.0474
Entamoeba histolytica Ran family GTPase 0.0025 0.0084 0.5279
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0474 0.0474
Onchocerca volvulus 0.0038 0.0474 0.5
Echinococcus granulosus neuroligin 0.0038 0.0474 0.0474
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0474 0.0474
Brugia malayi Carboxylesterase family protein 0.0038 0.0474 0.0538
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0158 0.018
Echinococcus granulosus acetylcholinesterase 0.0224 0.6006 0.6006
Echinococcus multilocularis acetylcholinesterase 0.0224 0.6006 0.6006
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0084 1
Echinococcus multilocularis neuroligin 0.0038 0.0474 0.0474
Trichomonas vaginalis ran, putative 0.0025 0.0084 0.0095
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0038 0.0474 0.0474
Trichomonas vaginalis spcc417.12 protein, putative 0.0038 0.0474 0.0538
Schistosoma mansoni glutaminase 0.0319 0.8808 0.8808
Leishmania major importin beta-1 subunit, putative 0.0027 0.0158 1
Onchocerca volvulus 0.0038 0.0474 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0158 0.018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0474 0.0474
Schistosoma mansoni hypothetical protein 0.0197 0.5212 0.5212
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0224 0.6006 0.6006
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0084 0.0095
Loa Loa (eye worm) carboxylesterase 0.0038 0.0474 0.0474
Brugia malayi Carboxylesterase family protein 0.0038 0.0474 0.0538
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0347 1
Brugia malayi Carboxylesterase family protein 0.0038 0.0474 0.0538
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Onchocerca volvulus 0.0038 0.0474 0.5
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0084 0.2408
Schistosoma mansoni hypothetical protein 0.0359 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0084 0.0084
Mycobacterium ulcerans glutaminase 0.0319 0.8808 1
Schistosoma mansoni ran 0.0025 0.0084 0.0084
Echinococcus multilocularis snurportin 1 0.0359 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0038 0.0474 0.0538
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0038 0.0474 1
Brugia malayi Carboxylesterase family protein 0.0224 0.6006 0.6819
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0084 0.2408
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Leishmania major GTP-binding protein, putative 0.0025 0.0084 0.5279
Schistosoma mansoni ran 0.0025 0.0084 0.0084
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0224 0.6006 0.6006
Loa Loa (eye worm) glutaminase 0.0319 0.8808 0.8808
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0084 0.2408
Schistosoma mansoni acetylcholinesterase 0.0038 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0038 0.0474 0.0474
Loa Loa (eye worm) acetylcholinesterase 1 0.0224 0.6006 0.6006
Brugia malayi RNA, U transporter 1 0.0096 0.2186 0.2482
Echinococcus multilocularis geminin 0.0197 0.5212 0.5212
Onchocerca volvulus 0.0038 0.0474 0.5
Echinococcus granulosus carboxylesterase 5A 0.0224 0.6006 0.6006
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0224 0.6006 0.6006
Onchocerca volvulus 0.0038 0.0474 0.5
Echinococcus granulosus importin subunit beta 1 0.0034 0.0347 0.0347
Mycobacterium tuberculosis Carboxylesterase LipT 0.0038 0.0474 1
Entamoeba histolytica hypothetical protein 0.0027 0.0158 1
Brugia malayi Carboxylesterase family protein 0.0224 0.6006 0.6819
Schistosoma mansoni hypothetical protein 0.0197 0.5212 0.5212
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0 0.5
Schistosoma mansoni gliotactin 0.0038 0.0474 0.0474
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0084 0.0084
Echinococcus granulosus geminin 0.0197 0.5212 0.5212
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0084 0.5279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0347 0.0347
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0359 1 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0038 0.0474 0.0474
Schistosoma mansoni neuroligin 3 (S09 family) 0.0038 0.0474 0.0474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0158 0.018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0084 0.5279
Loa Loa (eye worm) carboxylesterase 0.0038 0.0474 0.0474
Loa Loa (eye worm) glutaminase 2 0.0319 0.8808 0.8808
Brugia malayi Carboxylesterase family protein 0.0038 0.0474 0.0538
Loa Loa (eye worm) carboxylesterase 0.0224 0.6006 0.6006

Activities

Activity type Activity value Assay description Source Reference
Mutation frequency (functional) = 3 Ames activity in TA 98+S9, expressed as maximum fold increase in mutation frequency ChEMBL. 12139462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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