Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.5227 | 0.9197 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.5683 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5683 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5683 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.5227 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.5227 | 0.9197 |
Onchocerca volvulus | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibitory activity of compound against Monoamine oxidase A isolated from rat liver mitochondria using [14C]-5-HT creatinine sulfate; NI denotes no inhibition at 1000 uM | ChEMBL. | 15189042 |
IC50 (binding) | NI 0 uM | Inhibitory activity of compound against Monoamine oxidase A isolated from rat liver mitochondria using [14C]-5-HT creatinine sulfate; NI denotes no inhibition at 1000 uM | ChEMBL. | 15189042 |
IC50 (binding) | = 72 uM | Inhibition of Monoamine oxidase B from rat liver mitochondria | ChEMBL. | 15189042 |
IC50 (binding) | = 72 uM | Inhibition of Monoamine oxidase B from rat liver mitochondria | ChEMBL. | 15189042 |
Inhibition (functional) | = 0 % | In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 2 ug/mL | ChEMBL. | 15189042 |
Inhibition (functional) | = 0 % | In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 0.2 ug/mL | ChEMBL. | 15189042 |
Inhibition (functional) | = 0 % | In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 2 ug/mL | ChEMBL. | 15189042 |
Inhibition (functional) | = 0 % | In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 0.2 ug/mL | ChEMBL. | 15189042 |
Inhibition (functional) | = 40.3 % | In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 20 ug/mL | ChEMBL. | 15189042 |
Inhibition (functional) | = 40.3 % | In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 20 ug/mL | ChEMBL. | 15189042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.