Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0148 | 0.8826 | 0.8808 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8826 | 0.8808 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0158 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0158 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 0.8826 | 0.8808 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 0.8826 | 0.8808 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 0.8826 | 0.8808 |
Echinococcus granulosus | carboxylesterase 5A | 0.0148 | 0.8826 | 0.8808 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1777 | 0.1655 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 0.8826 | 0.8808 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0148 | 0.8826 | 0.8808 |
Echinococcus granulosus | insulin receptor | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8826 | 0.8808 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0158 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.1923 | 0.1803 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0158 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | carboxylesterase | 0.0148 | 0.8826 | 0.8808 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0148 | 0.8826 | 0.8826 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0146 | 0.0146 |
Brugia malayi | Carboxylesterase family protein | 0.0148 | 0.8826 | 0.8808 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0148 | 0.8826 | 0.8808 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0146 | 0.0146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activation (functional) | 0 % | Percent insulin like growth factor receptor(IGFIR) activity at 30 uM (NS = less than 5% activation) | ChEMBL. | 11000003 |
Activation (functional) | 0 % | Percent platelet derived growth factor receptor (PDGFR) activity at 30 uM (NS = less than 5% activation) | ChEMBL. | 11000003 |
EC50 (binding) | = 30 uM | Activation of human insulin receptor tyrosine kinase (IRTK) | ChEMBL. | 11000003 |
EC50 (binding) | = 30 uM | Activation of human insulin receptor tyrosine kinase (IRTK) | ChEMBL. | 11000003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.