Detailed information for compound 203219

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.892 | Formula: C20H26ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCC/N=C/1\CC(C)(C)Cc2c1c(=O)c1cc(Cl)ccc1n2O)C
  • InChi: 1S/C20H26ClN3O2/c1-20(2)11-15(22-8-5-9-23(3)4)18-17(12-20)24(26)16-7-6-13(21)10-14(16)19(18)25/h6-7,10,26H,5,8-9,11-12H2,1-4H3/b22-15+
  • InChiKey: ZBIXLUZIDAKTEL-PXLXIMEGSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0858 0.6867 0.6867
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0858 0.6867 0.6867
Mycobacterium ulcerans proteasome PrcB 0.1244 1 1
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0244 0.1889 0.1889
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0012 0.0007 0.5
Loa Loa (eye worm) proteasome subunit beta type 1 0.0966 0.7748 0.7748
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0003 0.0003
Brugia malayi Nuclear hormone receptor E75 0.0405 0.319 0.319
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Brugia malayi nuclear receptor NHR-88 0.0858 0.6867 0.6867
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0065 0.0065
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0599 0.4765 0.4765
Entamoeba histolytica hypothetical protein 0.0027 0.0127 0.0127
Entamoeba histolytica hypothetical protein 0.0027 0.0127 0.0127
Leishmania major sterol C-24 reductase, putative 0.0042 0.0248 0.0248
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0012 0.0007 0.0007
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0244 0.1889 0.1887
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0012 0.0007 0.0007
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0244 0.1889 0.1889
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0073 0.0498 0.0498
Echinococcus multilocularis neuropeptide s receptor 0.0351 0.2751 0.2751
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0073 0.0498 0.0495
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.1889 0.1889
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0858 0.6867 0.6867
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0073 0.0498 0.0498
Brugia malayi 20S proteasome alpha5 subunit 0.0244 0.1889 0.1889
Loa Loa (eye worm) phospholipase D 0.0015 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0858 0.6867 0.6867
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0244 0.1889 0.1889
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0073 0.0498 0.0495
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0244 0.1889 0.1889
Entamoeba histolytica phospholipase D, putative 0.0078 0.0539 0.0539
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0073 0.0498 0.0495
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0073 0.0498 0.0495
Echinococcus granulosus dnaJ subfamily B 0.031 0.2423 0.2423
Plasmodium vivax proteasome subunit beta type-5, putative 0.1244 1 1
Echinococcus multilocularis dnaJ subfamily B 0.031 0.2423 0.2423
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.1005 0.1005
Echinococcus granulosus proteasome subunit beta type 6 0.0244 0.1889 0.1889
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0966 0.7748 0.7748
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0244 0.1889 0.1889
Brugia malayi steroid hormone receptor 0.0858 0.6867 0.6867
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0003 0.0003
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0966 0.7748 0.7748
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0003 0.0003
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0244 0.1889 0.1889
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0244 0.1889 0.1889
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0453 0.3584 0.3584
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0244 0.1889 0.1889
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0073 0.0498 0.0495
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0244 0.1889 0.1889
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0858 0.6867 0.6867
Echinococcus multilocularis GPCR, family 2 0.0012 0.0003 0.0003
Plasmodium vivax proteasome subunit beta type-2, putative 0.0599 0.4765 0.4765
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0048 0.0293 0.0293
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0073 0.0498 0.0498
Brugia malayi Pre-SET motif family protein 0.002 0.0065 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0134 0.0994 0.0994
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0244 0.1889 0.1889
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0244 0.1889 0.1889
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0858 0.6867 0.6867
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0073 0.0498 0.0495
Trypanosoma brucei proteasome beta 7 subunit 0.0244 0.1889 0.1889
Trypanosoma cruzi cardiolipin synthetase, putative 0.0027 0.0127 0.0127
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1244 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0351 0.2751 0.2751
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0048 0.0293 0.0293
Echinococcus granulosus proteasome subunit alpha type 6 0.0244 0.1889 0.1889
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0003 0.0003
Plasmodium vivax proteasome subunit beta type-4, putative 0.0244 0.1889 0.1889
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0244 0.1889 0.1889
Brugia malayi Proteasome A-type and B-type family protein 0.0244 0.1889 0.1889
Onchocerca volvulus 0.0095 0.0677 0.0985
Onchocerca volvulus 0.002 0.0065 0.0095
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0858 0.6867 0.6867
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.1889 0.1889
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Echinococcus granulosus lamin b receptor 0.0042 0.0248 0.0248
Brugia malayi tailless protein 0.0405 0.319 0.319
Giardia lamblia Proteasome subunit beta type 1 0.0966 0.7748 0.7224
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0244 0.1889 0.1889
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1244 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0073 0.0498 0.0495
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0858 0.6867 0.6867
Schistosoma mansoni hypothetical protein 0.0027 0.0127 0.0127
Plasmodium vivax proteasome subunit beta type-1, putative 0.0966 0.7748 0.7748
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1244 1 1
Schistosoma mansoni phospholipase D 0.0078 0.0539 0.0539
Leishmania major proteasome beta 3 subunit, putative 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0073 0.0498 0.0498
Leishmania major proteasome beta-1 subunit, putative 0.0244 0.1889 0.1889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.1889 0.1889
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0073 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0066 0.0438 0.0438
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0073 0.0498 0.0495
Echinococcus granulosus phospholipase D1 0.0078 0.0539 0.0539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0858 0.6867 0.6867
Onchocerca volvulus 0.0405 0.319 0.4645
Leishmania major proteasome beta 5 subunit, putative 0.1244 1 1
Loa Loa (eye worm) hypothetical protein 0.0508 0.4032 0.4032
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1495 0.1495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0083 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0073 0.0498 0.0495
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0405 0.319 0.319
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0599 0.4765 0.4765
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0003 0.0003
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.0725 0.0725
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0073 0.0498 0.0495
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1244 1 1
Brugia malayi proteasome subunit alpha type 4 0.0244 0.1889 0.1889
Brugia malayi Nuclear hormone receptor-like 1 0.0453 0.3584 0.3584
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis high affinity choline transporter 1 0.0048 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0051 0.0318 0.0318
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0244 0.1889 0.1889
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0244 0.1889 0.1889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.1889 0.1889
Entamoeba histolytica hypothetical protein 0.0027 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0073 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Echinococcus multilocularis cpg binding protein 0.0023 0.0093 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0073 0.0498 0.0495
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0003 0.0003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0405 0.319 0.319
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0287 0.0287
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Echinococcus granulosus FTZ F1 alpha 0.0858 0.6867 0.6867
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0966 0.7748 0.7748
Plasmodium vivax SET domain protein, putative 0.002 0.0065 0.0065
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0244 0.1889 0.1889
Toxoplasma gondii heat shock protein hslv, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis ecdysone induced protein 78C 0.0858 0.6867 0.6867
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0073 0.0498 0.0498
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0073 0.0498 0.0498
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0073 0.0498 0.0498
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0003 0.0003
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0599 0.4765 0.4765
Schistosoma mansoni high-affinity choline transporter 0.0048 0.0293 0.0293
Schistosoma mansoni zinc finger protein 0.0405 0.319 0.319
Echinococcus granulosus neuropeptide s receptor 0.0351 0.2751 0.2751
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0101 0.0725 0.0725
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1244 1 1
Schistosoma mansoni cpg binding protein 0.0023 0.0093 0.0093
Chlamydia trachomatis phospholipase D superfamily protein 0.0012 0.0007 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Loa Loa (eye worm) nuclear hormone receptor 0.0405 0.319 0.319
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0073 0.0498 0.0498
Toxoplasma gondii proteasome subunit beta type, putative 0.1244 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0003 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0073 0.0498 0.0498
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0027 0.0127 0.0127
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0065 0.0065
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0244 0.1889 0.1889
Brugia malayi CXXC zinc finger family protein 0.0022 0.0083 0.0083
Trypanosoma brucei proteasome beta 6 subunit 0.0966 0.7748 0.7748
Brugia malayi nuclear receptor NHR-67 0.0405 0.319 0.319
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0599 0.4765 0.4765
Schistosoma mansoni cytochrome P450 0.0073 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0073 0.0498 0.0498
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0858 0.6867 0.6867
Leishmania major proteasome alpha 3 subunit, putative 0.0244 0.1889 0.1889
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0244 0.1889 0.1889
Chlamydia trachomatis phospholipase D superfamily protein 0.0012 0.0007 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0858 0.6867 0.6867
Echinococcus granulosus nuclear receptor nhr 48 0.0405 0.319 0.319
Echinococcus granulosus proteasome subunit beta type 7 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0073 0.0498 0.0498
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0966 0.7748 0.7748
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0244 0.1889 0.1889
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0244 0.1889 0.1889
Brugia malayi conserved hypotetical protein 0.0405 0.319 0.319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0405 0.319 0.319
Mycobacterium ulcerans proteasome PrcA 0.0244 0.1889 0.1889
Echinococcus multilocularis phospholipase d3 0.0015 0.0025 0.0025
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0244 0.1889 0.1889
Brugia malayi nuclear hormone receptor family member odr-7 0.0405 0.319 0.319
Leishmania major cytochrome p450-like protein 0.0073 0.0498 0.0498
Brugia malayi Phospholipase D. Active site motif family protein 0.0015 0.0025 0.0025
Trypanosoma brucei cardiolipin synthetase, putative 0.0027 0.0127 0.0127
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0405 0.319 0.319
Loa Loa (eye worm) proteasome subunit beta type 3 0.0244 0.1889 0.1889
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0003 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0858 0.6867 1
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1495 0.1495
Onchocerca volvulus 0.0405 0.319 0.4645
Schistosoma mansoni nuclear receptor nhr-48 0.0405 0.319 0.319
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0065 0.0065
Leishmania major C-8 sterol isomerase-like protein 0.0508 0.4032 0.4032
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0073 0.0498 0.0498
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0244 0.1889 0.1889
Plasmodium vivax proteasome subunit beta type-6, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.026 0.2015 0.2015
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi C-14 sterol reductase, putative 0.0042 0.0248 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0858 0.6867 0.6867
Toxoplasma gondii proteasome subunit alpha type, putative 0.0244 0.1889 0.1889
Giardia lamblia Proteasome subunit beta type 2 0.0599 0.4765 0.3546
Echinococcus granulosus thyroid hormone receptor alpha 0.0405 0.319 0.319
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0218 0.1674 0.1674
Brugia malayi Protein K4 0.0012 0.0007 0.0007
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Schistosoma mansoni hypothetical protein 0.0026 0.0116 0.0116
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0966 0.7748 0.7748
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0479 0.3796 0.3796
Schistosoma mansoni microtubule-associated protein tau 0.0523 0.4152 0.4152
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0244 0.1889 0.1889
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0065 0.0065
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0244 0.1889 0.1889
Brugia malayi Proteasome A-type and B-type family protein 0.0244 0.1889 0.1889
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0012 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0003 0.0003
Echinococcus granulosus GPCR family 2 0.0012 0.0003 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0453 0.3584 0.3584
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0244 0.1889 0.1889
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0073 0.0498 0.0498
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0073 0.0498 0.0498
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0453 0.3584 0.3584
Brugia malayi Nuclear hormone receptor-like 1 0.0858 0.6867 0.6867
Echinococcus granulosus leukotriene A 4 hydrolase 0.0218 0.1674 0.1674
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0858 0.6867 0.6867
Brugia malayi proteasome subunit alpha type 2 0.0244 0.1889 0.1889
Leishmania major proteasome beta 2 subunit, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0858 0.6867 0.6867
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0858 0.6867 0.6867
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0244 0.1889 0.1889
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0244 0.1889 0.1889
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0244 0.1889 0.1889
Schistosoma mansoni thyroid hormone receptor 0.0953 0.7642 0.7642
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis proteasome (prosome, macropain) 0.1244 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0858 0.6867 0.6867
Loa Loa (eye worm) hypothetical protein 0.0046 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0858 0.6867 0.6867
Trypanosoma brucei cytochrome P450, putative 0.0101 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Brugia malayi photoreceptor-specific nuclear receptor 0.0858 0.6867 0.6867
Schistosoma mansoni nuclear hormone receptor 0.0405 0.319 0.319
Brugia malayi Cytochrome P450 family protein 0.0073 0.0498 0.0498
Echinococcus multilocularis thyroid hormone receptor alpha 0.0953 0.7642 0.7642
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0858 0.6867 0.6867
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0244 0.1889 0.1889
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0003 0.0003
Trypanosoma cruzi cytochrome P450, putative 0.0101 0.0725 0.0725
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0247 0.0247
Trichomonas vaginalis set domain proteins, putative 0.0153 0.1144 0.1144
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0095 0.0677 0.0677
Brugia malayi Proteasome subunit alpha type 1 0.0244 0.1889 0.1889
Trypanosoma brucei C-14 sterol reductase, putative 0.0042 0.0248 0.0248
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0244 0.1889 0.1889
Schistosoma mansoni hypothetical protein 0.0095 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Leishmania major cytochrome p450-like protein 0.0073 0.0498 0.0498
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0073 0.0498 0.0495
Schistosoma mansoni retinoic acid receptor RXR 0.0933 0.7474 0.7474
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0073 0.0498 0.0498
Echinococcus multilocularis phospholipase D1 0.0078 0.0539 0.0539
Echinococcus multilocularis lamin b receptor 0.0042 0.0248 0.0248
Onchocerca volvulus 0.0153 0.1144 0.1666
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0244 0.1889 0.1889
Brugia malayi Phospholipase d protein 1 0.0078 0.0539 0.0539
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0066 0.0438 0.0438
Leishmania major cardiolipin synthetase, putative 0.0012 0.0007 0.0007
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis proteasome subunit beta type 7 0.0244 0.1889 0.1889
Brugia malayi Steroid receptor seven-up type 2 0.0858 0.6867 0.6867
Onchocerca volvulus Glucosylceramidase homolog 0.0128 0.0949 0.1381
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0405 0.319 0.319
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0244 0.1889 0.1889
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0405 0.319 0.319
Schistosoma mansoni nuclear hormone receptor 0.0858 0.6867 0.6867
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0003 0.0003
Echinococcus multilocularis nuclear receptor nhr 48 0.0405 0.319 0.319
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0073 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0048 0.0293 0.0293
Trypanosoma brucei Emopamil binding protein, putative 0.0095 0.0677 0.0677
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0196 0.1495 0.1495
Echinococcus granulosus proteasome subunit alpha type 2 0.0244 0.1889 0.1889
Leishmania major C-14 sterol reductase, putative 0.0042 0.0248 0.0248
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1244 1 1
Echinococcus granulosus cpg binding protein 0.0023 0.0093 0.0093
Entamoeba histolytica phospholipase D, putative 0.0078 0.0539 0.0539
Echinococcus granulosus sodium:myo inositol cotransporter 0.0187 0.1421 0.1421
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0244 0.1889 0.1889
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0095 0.0677 0.0677
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.1889 0.1889
Echinococcus granulosus ecdysone induced protein 78C 0.0858 0.6867 0.6867
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1495 0.1495
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0244 0.1889 0.1889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.1889 0.1889
Schistosoma mansoni nuclear receptor 0.0405 0.319 0.319
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0244 0.1889 0.1889
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0015 0.0025 0.0025
Trypanosoma cruzi C-14 sterol reductase, putative 0.0042 0.0248 0.0248
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0073 0.0498 0.0498
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0073 0.0498 0.0495
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0244 0.1889 0.1889
Brugia malayi proteasome subunit alpha type 3 0.0244 0.1889 0.1889
Schistosoma mansoni cpg binding protein 0.0022 0.0083 0.0083
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0003 0.0003
Onchocerca volvulus Putative phospholipase D 0.0015 0.0025 0.0037
Trypanosoma cruzi sterol C-24 reductase, putative 0.0042 0.0248 0.0248
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0599 0.4765 0.4765
Schistosoma mansoni cpg binding protein 0.0023 0.0093 0.0093
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Toxoplasma gondii proteasome subunit 0.0244 0.1889 0.1889
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0453 0.3584 0.3584
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0003 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0012 0.0003 0.0003
Brugia malayi cytochrome P450 0.0073 0.0498 0.0498
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0244 0.1889 0.1889
Echinococcus granulosus Proteasome subunit alpha beta 0.0244 0.1889 0.1889
Echinococcus granulosus proteasome prosome macropain 0.1244 1 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0244 0.1889 0.1889
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0073 0.0498 0.0495
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0073 0.0498 0.0495
Plasmodium falciparum proteasome subunit beta type-5 0.1244 1 1
Brugia malayi hypothetical protein 0.0453 0.3584 0.3584
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0858 0.6867 0.6867
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0293 0.0293
Trypanosoma brucei cardiolipin synthetase 0.0027 0.0127 0.0127
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0244 0.1889 0.1889
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0508 0.4032 0.4032
Schistosoma mansoni hypothetical protein 0.0237 0.1832 0.1832
Echinococcus granulosus microtubule associated protein 2 0.0523 0.4152 0.4152
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0244 0.1889 0.1889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.1889 0.1889
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0196 0.1495 0.1495
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0048 0.0293 0.0293
Leishmania major proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0966 0.7748 0.7748
Leishmania major proteasome alpha 1 subunit, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Onchocerca volvulus Notchless protein homolog 0.0244 0.1889 0.2751
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0858 0.6867 0.6867
Plasmodium vivax proteasome subunit beta type-3, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis proteasome subunit alpha type 6 0.0244 0.1889 0.1889
Echinococcus granulosus Nuclear hormone receptor HR96 0.0405 0.319 0.319
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0405 0.319 0.4645
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0065 0.0065
Brugia malayi hypothetical protein 0.0405 0.319 0.319
Echinococcus granulosus phospholipase d3 0.0015 0.0025 0.0025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0933 0.7474 0.7474
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0599 0.4765 0.4765
Brugia malayi Proteasome subunit alpha type 7-1 0.0244 0.1889 0.1889
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0244 0.1889 0.1889
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1495 0.1495
Onchocerca volvulus Bile acid receptor homolog 0.0858 0.6867 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0218 0.1674 0.1674
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0244 0.1889 0.1889
Brugia malayi isocitrate dehydrogenase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0318 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0453 0.3584 0.3584
Trypanosoma brucei proteasome alpha 7 subunit 0.0244 0.1889 0.1889
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0966 0.7748 0.7748
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0244 0.1889 0.1889
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Plasmodium vivax proteasome subunit beta type-7, putative 0.0244 0.1889 0.1889
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0012 0.0007 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0065 0.0065
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0244 0.1889 0.1889
Brugia malayi proteasome subunit beta type 3 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0244 0.1889 0.1889
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0244 0.1889 0.1889
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0012 0.0007 0.0007
Echinococcus multilocularis geminin 0.0237 0.1832 0.1832
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0599 0.4765 0.4765
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0073 0.0498 0.0498
Brugia malayi orphan nuclear receptor NR2E1 0.0405 0.319 0.319
Loa Loa (eye worm) nuclear receptor NHR-67 0.0405 0.319 0.319
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0012 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0095 0.0677 0.0677
Loa Loa (eye worm) proteasome subunit beta type 2 0.0599 0.4765 0.4765
Loa Loa (eye worm) hypothetical protein 0.041 0.3234 0.3234
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1495 0.1495
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0599 0.4765 0.4765
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0599 0.4765 0.4765
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0244 0.1889 0.1889
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0244 0.1889 0.1889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.1889 0.1889
Schistosoma mansoni hypothetical protein 0.031 0.2423 0.2423
Brugia malayi GH02984p 0.0048 0.0293 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Schistosoma mansoni nuclear receptor 0.0405 0.319 0.319
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0073 0.0498 0.0495
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0244 0.1889 0.1889
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0858 0.6867 0.6867
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0244 0.1889 0.1889
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0966 0.7748 0.7748
Loa Loa (eye worm) steroid hormone receptor 0.0858 0.6867 0.6867
Toxoplasma gondii proteasome subunit alpha1, putative 0.0244 0.1889 0.1889
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0244 0.1889 0.1889
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0073 0.0498 0.0495
Echinococcus granulosus sodium:glucose cotransporter 2 0.0187 0.1421 0.1421
Loa Loa (eye worm) hypothetical protein 0.0048 0.0298 0.0298
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0003 0.0003
Brugia malayi proteasome subunit alpha type 1 0.0244 0.1889 0.1889
Brugia malayi Cytochrome P450 family protein 0.0101 0.0725 0.0725
Leishmania major proteasome alpha 1 subunit, putative 0.0244 0.1889 0.1889
Entamoeba histolytica hypothetical protein 0.0027 0.0127 0.0127
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0244 0.1889 1
Leishmania major proteasome beta 2 subunit, putative 0.0599 0.4765 0.4765
Schistosoma mansoni steroid hormone receptor ad4bp 0.0858 0.6867 0.6867
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi sterol C-24 reductase, putative 0.0042 0.0248 0.0248
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0187 0.1421 0.1421
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0858 0.6867 0.6867
Echinococcus granulosus high affinity choline transporter 1 0.0048 0.0293 0.0293
Schistosoma mansoni coup transcription factor 0.0858 0.6867 0.6867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0065 0.0065
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0858 0.6867 0.6867
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1244 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0949 0.0949
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0858 0.6867 0.6867
Echinococcus granulosus subfamily T1A non peptidase ue 0.0244 0.1889 0.1889
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0244 0.1889 0.1889
Schistosoma mansoni nuclear hormone receptor 0.0405 0.319 0.319
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0599 0.4765 0.4765
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Echinococcus multilocularis phospholipase D 0.0069 0.0465 0.0465
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0012 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0073 0.0498 0.0498
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0966 0.7748 0.7748
Loa Loa (eye worm) CYP4Cod1 0.0101 0.0725 0.0725
Loa Loa (eye worm) PAS-3 protein 0.0244 0.1889 0.1889
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0244 0.1889 0.1889
Leishmania major proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Brugia malayi proteasome subunit beta type 2 0.0599 0.4765 0.4765
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0073 0.0498 0.0495
Brugia malayi Pre-SET motif family protein 0.0134 0.0994 0.0994
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0244 0.1889 0.1889
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0858 0.6867 0.6867
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0858 0.6867 0.6867
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.1889 0.1889
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0858 0.6867 0.6867
Brugia malayi Nuclear hormone receptor-like 1 0.0453 0.3584 0.3584
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0073 0.0498 0.0498
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0244 0.1889 0.1889
Trypanosoma cruzi Emopamil binding protein, putative 0.0095 0.0677 0.0677
Brugia malayi proteasome subunit beta type 1 0.0966 0.7748 0.7748
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0244 0.1889 0.1889
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0244 0.1889 0.1889
Leishmania major cytochrome p450-like protein 0.0101 0.0725 0.0725
Echinococcus multilocularis neuropeptide receptor A26 0.0351 0.2751 0.2751
Toxoplasma gondii cytochrome p450 superfamily protein 0.0073 0.0498 0.0498
Schistosoma mansoni Lamin B receptor (ERG24) 0.0042 0.0248 0.0248
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0027 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0237 0.1832 0.1832
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0244 0.1889 0.1889
Loa Loa (eye worm) DR-78 0.0405 0.319 0.319
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0244 0.1889 0.1889
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0858 0.6867 0.6867
Brugia malayi Sodium:solute symporter family protein 0.0048 0.0293 0.0293
Brugia malayi hypothetical protein 0.0453 0.3584 0.3584
Brugia malayi hypothetical protein 0.0012 0.0007 0.0007
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0003 0.0003
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0244 0.1889 0.1889
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.1889 0.1889
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0095 0.0681 0.0681
Onchocerca volvulus Protein ultraspiracle homolog 0.0858 0.6867 1
Echinococcus granulosus Proteasome subunit alpha type 7 0.0244 0.1889 0.1889
Brugia malayi nuclear hormone receptor 0.0858 0.6867 0.6867
Brugia malayi hypothetical protein 0.01 0.0719 0.0719
Brugia malayi hypothetical protein 0.0405 0.319 0.319
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0244 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0073 0.0498 0.0498
Onchocerca volvulus 0.0048 0.0298 0.0433
Schistosoma mansoni inositol transporter 0.0187 0.1421 0.1421
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Loa Loa (eye worm) hypothetical protein 0.0453 0.3584 0.3584
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0213 0.0213
Brugia malayi proteasome subunit alpha type 6 0.0244 0.1889 0.1889
Echinococcus granulosus cytochrome P450 2K1 0.0073 0.0498 0.0498
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0244 0.1889 0.1889
Echinococcus granulosus solute carrier family 5 0.0187 0.1421 0.1421
Brugia malayi Cytochrome P450 family protein 0.0073 0.0498 0.0498
Brugia malayi GYF domain containing protein 0.0048 0.0298 0.0298
Schistosoma mansoni transcription factor LCR-F1 0.0027 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus multilocularis 0.0073 0.0498 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0858 0.6867 0.6867
Echinococcus multilocularis proteasome subunit beta type 6 0.0244 0.1889 0.1889
Echinococcus multilocularis solute carrier family 5 0.0187 0.1421 0.1421
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0966 0.7748 0.7748
Brugia malayi ecdysteroid receptor 0.0858 0.6867 0.6867
Schistosoma mansoni inositol transporter 0.0187 0.1421 0.1421
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0405 0.319 0.4645
Echinococcus multilocularis FTZ F1 alpha 0.0858 0.6867 0.6867
Brugia malayi hypothetical protein 0.0027 0.0127 0.0127
Brugia malayi nuclear receptor NHR-88 0.0405 0.319 0.319
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0405 0.319 0.319
Trypanosoma brucei C-8 sterol isomerase, putative 0.0508 0.4032 0.4032
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0218 0.1674 0.1674
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0858 0.6867 0.6867
Onchocerca volvulus 0.0858 0.6867 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0858 0.6867 0.6867
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0073 0.0498 0.0498
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0073 0.0498 0.0498
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Onchocerca volvulus 0.0022 0.0083 0.0121
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Echinococcus granulosus sodium:glucose cotransporter 0.0187 0.1421 0.1421
Echinococcus multilocularis proteasome subunit alpha type 2 0.0244 0.1889 0.1889
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0066 0.0438 0.0438
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0453 0.3584 0.3584
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0187 0.1421 0.1421
Echinococcus multilocularis microtubule associated protein 2 0.0523 0.4152 0.4152
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0025
Leishmania major proteasome alpha 2 subunit, putative 0.0244 0.1889 0.1889
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0244 0.1889 0.1889
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0012 0.0007 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0858 0.6867 0.6867
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0244 0.1889 0.1889
Leishmania major proteasome beta 7 subunit, putative 0.0244 0.1889 0.1889
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Trypanosoma cruzi cytochrome P450, putative 0.0101 0.0725 0.0725
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0453 0.3584 0.3584
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0073 0.0498 0.0495
Plasmodium falciparum proteasome subunit beta type-4 0.0244 0.1889 0.1889
Brugia malayi nuclear receptor RXR 0.0453 0.3584 0.3584
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0012 0.0003 0.0003
Loa Loa (eye worm) cytochrome P450 0.0073 0.0498 0.0498
Brugia malayi Proteasome A-type and B-type family protein 0.0244 0.1889 0.1889
Plasmodium vivax cardiolipin synthetase, putative 0.0012 0.0007 0.0007
Echinococcus granulosus proteasome subunit beta t family 0.0244 0.1889 0.1889
Toxoplasma gondii proteasome beta subunit 0.0244 0.1889 0.1889
Brugia malayi Phospholipase D. Active site motif family protein 0.0027 0.0127 0.0127
Brugia malayi nuclear receptor RXR 0.0405 0.319 0.319
Loa Loa (eye worm) hypothetical protein 0.0453 0.3584 0.3584
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0405 0.319 0.319
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0405 0.319 0.319
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0073 0.0498 0.0498
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0213 0.0213
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.0725 0.0725
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0858 0.6867 0.6867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0858 0.6867 0.6867
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.1889 0.1889
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0244 0.1889 0.1889
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0073 0.0498 0.0495
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0244 0.1889 0.1889
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0405 0.319 0.319
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0244 0.1889 0.1889
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0095 0.0681 0.0681
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1244 1 1
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi 20S proteasome subunit 0.0599 0.4765 0.4765
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0858 0.6867 0.6867
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0244 0.1889 0.1889
Brugia malayi nuclear hormone receptor 0.0405 0.319 0.319
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1244 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0065
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Loa Loa (eye worm) hypothetical protein 0.0038 0.0213 0.0213
Toxoplasma gondii peptidase, T1 family protein 0.0244 0.1889 0.1889
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0858 0.6867 0.6867
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0027 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0453 0.3584 0.3584
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0073 0.0498 0.0498
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1495 0.1495
Brugia malayi ecdysone receptor 0.0405 0.319 0.319
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0244 0.1889 0.1889
Trypanosoma cruzi cardiolipin synthetase, putative 0.0027 0.0127 0.0127
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0244 0.1889 0.1889
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0858 0.6867 0.6867
Brugia malayi Cytochrome P450 family protein 0.0101 0.0725 0.0725
Onchocerca volvulus 0.0048 0.0293 0.0426
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0244 0.1889 0.1889
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0244 0.1889 0.1889
Schistosoma mansoni sodium/solute symporter 0.0048 0.0293 0.0293
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0095 0.0677 0.0677
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0244 0.1889 0.1889
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0858 0.6867 0.6867
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0244 0.1889 0.1464
Loa Loa (eye worm) hypothetical protein 0.0858 0.6867 0.6867
Trypanosoma cruzi Emopamil binding protein, putative 0.0095 0.0677 0.0677
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0244 0.1889 0.1889
Schistosoma mansoni thyroid hormone receptor 0.0953 0.7642 0.7642
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0012 0.0007 0.5
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0244 0.1889 0.1889
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0858 0.6867 0.6867
Brugia malayi Nuclear hormone receptor E75 0.0405 0.319 0.319
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0244 0.1889 0.1889
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0244 0.1889 0.1889
Echinococcus granulosus geminin 0.0237 0.1832 0.1832
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.1005 0.1005
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0405 0.319 0.319
Echinococcus granulosus phospholipase D 0.0069 0.0465 0.0465
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.1889 0.1889
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1244 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0599 0.4765 0.4765
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0405 0.319 0.319
Echinococcus granulosus Nuclear hormone receptor HR96 0.0405 0.319 0.319
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0508 0.4032 0.4032

Activities

Activity type Activity value Assay description Source Reference
Delta mean survival time (functional) = 0.2 Antimalarial activity of the compound was measured in mice infected with Plasmodium berghei by subcutaneous administraton at 40 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 0.4 Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 2.8 Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg dose ChEMBL. 1404226
Delta mean survival time (functional) = 0.2 Antimalarial activity of the compound was measured in mice infected with Plasmodium berghei by subcutaneous administraton at 40 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 0.4 Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 2.8 Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg dose ChEMBL. 1404226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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