Detailed information for compound 203220

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 625.175 | Formula: C33H37ClN2O6S
  • H donors: 0 H acceptors: 3 LogP: 5.04 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C1(OCCO1)C1CCN(CC1)C1CCN(CC1)C(=O)c1ccccc1Cl
  • InChi: 1S/C33H37ClN2O6S/c1-40-27-8-12-29(13-9-27)43(38,39)28-10-6-24(7-11-28)33(41-22-23-42-33)25-14-18-35(19-15-25)26-16-20-36(21-17-26)32(37)30-4-2-3-5-31(30)34/h2-13,25-26H,14-23H2,1H3
  • InChiKey: SAMHBASXWCAOGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Muscarinic acetylcholine receptor M2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Muscarinic acetylcholine receptor M2   466 aa 461 aa 26.0 %
Schistosoma mansoni growth hormone secretagogue receptor Muscarinic acetylcholine receptor M2   466 aa 462 aa 19.9 %
Schistosoma japonicum Octopamine receptor 1, putative Muscarinic acetylcholine receptor M2   466 aa 412 aa 22.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Muscarinic acetylcholine receptor M2   466 aa 493 aa 34.7 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor M2   466 aa 484 aa 24.4 %
Echinococcus granulosus g protein coupled receptor Muscarinic acetylcholine receptor M2   466 aa 480 aa 18.5 %
Echinococcus multilocularis alpha 1A adrenergic receptor Muscarinic acetylcholine receptor M2   466 aa 459 aa 21.1 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Muscarinic acetylcholine receptor M2   466 aa 510 aa 29.8 %
Onchocerca volvulus Muscarinic acetylcholine receptor M2   466 aa 472 aa 24.6 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Muscarinic acetylcholine receptor M2   466 aa 505 aa 26.9 %
Echinococcus granulosus alpha 1A adrenergic receptor Muscarinic acetylcholine receptor M2   466 aa 459 aa 20.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Muscarinic acetylcholine receptor M2   466 aa 461 aa 23.9 %
Schistosoma japonicum Octopamine receptor, putative Muscarinic acetylcholine receptor M2   466 aa 462 aa 26.8 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor M2   466 aa 463 aa 24.2 %
Loa Loa (eye worm) TYRA-2 protein Muscarinic acetylcholine receptor M2   466 aa 497 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Proteasome subunit alpha type 7 0.013 0.1643 0.1641
Giardia lamblia Proteasome subunit beta type 9 precursor 0.013 0.1643 0.1771
Trypanosoma cruzi C-14 sterol reductase, putative 0.0057 0.06 0.0615
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0129 0.1623 0.1746
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0091 0.1075 0.1156
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0273 0.3696 0.3694
Toxoplasma gondii proteasome subunit 0.013 0.1643 0.1769
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0319 0.4351 0.4687
Onchocerca volvulus Bile acid receptor homolog 0.0517 0.7196 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.013 0.1643 0.1769
Echinococcus multilocularis proteasome subunit beta type 6 0.013 0.1643 0.1641
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.013 0.1643 0.1769
Leishmania major proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0007
Onchocerca volvulus Notchless protein homolog 0.013 0.1643 0.2215
Brugia malayi Proteasome subunit alpha type 1 0.013 0.1643 0.1684
Leishmania major proteasome beta 2 subunit, putative 0.0319 0.4351 0.4478
Loa Loa (eye worm) hypothetical protein 0.0273 0.3696 0.3799
Loa Loa (eye worm) proteasome subunit alpha type 6 0.013 0.1643 0.1684
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.013 0.1643 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0582 0.0625
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.001 0.0008
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.013 0.1643 0.169
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0091 0.1075 0.1104
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0091 0.1075 0.1148
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.1641 0.1639
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0517 0.7196 0.7407
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0319 0.4351 0.4349
Echinococcus multilocularis Proteasome subunit alpha type 7 0.013 0.1643 0.1641
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0517 0.7196 1
Giardia lamblia Proteasome subunit beta type 1 0.0515 0.7159 0.7715
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0244 0.3276 0.3367
Loa Loa (eye worm) DR-78 0.0244 0.3276 0.3367
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Chlamydia trachomatis phospholipase D superfamily protein 0.0017 0.002 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0517 0.7196 0.7195
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0662 0.9279 0.9554
Brugia malayi 20S proteasome alpha5 subunit 0.013 0.1643 0.1684
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0244 0.3276 0.3367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0517 0.7196 0.7407
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2422 0.102
Brugia malayi proteasome subunit alpha type 6 0.013 0.1643 0.1684
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0089 0.1056 0.1136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0324
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0679 0.0676
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0017 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0062 0.067 0.068
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0129 0.1632 0.1678
Toxoplasma gondii peptidase, T1 family protein 0.013 0.1643 0.1769
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0319 0.4351 0.4349
Echinococcus multilocularis phospholipase d3 0.002 0.0064 0.0061
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1643 0.169
Brugia malayi proteasome subunit beta type 3 0.013 0.1643 0.1684
Brugia malayi ecdysteroid receptor 0.0517 0.7196 0.7407
Loa Loa (eye worm) PAS-3 protein 0.013 0.1643 0.1684
Brugia malayi Cytochrome P450 family protein 0.0091 0.1075 0.1098
Trypanosoma cruzi cardiolipin synthetase, putative 0.0037 0.0308 0.0314
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0273 0.3696 0.3799
Echinococcus multilocularis phospholipase D 0.0094 0.1122 0.112
Echinococcus granulosus 20S proteasome subunit alpha 6 0.013 0.1643 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0517 0.7196 0.7407
Loa Loa (eye worm) proteasome subunit beta type 1 0.0515 0.7159 0.7369
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0091 0.1075 0.1156
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0319 0.4351 0.4478
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.013 0.1643 0.1684
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.013 0.1643 0.1769
Loa Loa (eye worm) hypothetical protein 0.0273 0.3696 0.3799
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0319 0.4351 0.3546
Loa Loa (eye worm) hypothetical protein 0.0354 0.4854 0.4993
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3602 0.2566
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.013 0.1643 0.1641
Toxoplasma gondii proteasome subunit beta type, putative 0.0662 0.9279 1
Brugia malayi Nuclear hormone receptor E75 0.0244 0.3276 0.3367
Leishmania major C-14 sterol reductase, putative 0.0057 0.06 0.0615
Brugia malayi Proteasome A-type and B-type family protein 0.013 0.1643 0.1684
Trypanosoma cruzi Emopamil binding protein, putative 0.0129 0.1632 0.1678
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.013 0.1643 0.1641
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.013 0.1643 0.169
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3602 0.2566
Trypanosoma brucei proteasome beta 6 subunit 0.0515 0.7159 0.7371
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0091 0.1075 0.1156
Leishmania major proteasome alpha 3 subunit, putative 0.013 0.1643 0.169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0517 0.7196 0.7407
Giardia lamblia Proteasome subunit beta type 4 precursor 0.013 0.1643 0.1771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0517 0.7196 0.7407
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.013 0.1643 0.169
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.013 0.1643 0.1641
Trypanosoma cruzi cardiolipin synthetase, putative 0.0037 0.0308 0.0314
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.013 0.1643 0.169
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0091 0.1075 0.1148
Schistosoma mansoni hypothetical protein 0.013 0.1641 0.1639
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Entamoeba histolytica phospholipase D, putative 0.0106 0.13 0.1399
Trypanosoma brucei cardiolipin synthetase 0.0037 0.0308 0.0314
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0017 0.002 0.0019
Plasmodium vivax proteasome subunit beta type-4, putative 0.013 0.1643 0.1769
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.013 0.1643 0.1769
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.013 0.1643 0.1641
Brugia malayi hypothetical protein 0.0273 0.3696 0.3799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0517 0.7196 0.7407
Brugia malayi Protein K4 0.0017 0.002 0.0011
Trypanosoma cruzi 20S proteasome subunit 0.0319 0.4351 0.4478
Brugia malayi cytochrome P450 0.0091 0.1075 0.1098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0517 0.7196 0.7407
Plasmodium vivax proteasome subunit alpha type-7, putative 0.013 0.1643 0.1769
Leishmania major phosphatidylglycerophosphate synthase, putative 0.002 0.0064 0.0063
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0515 0.7159 0.7158
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0517 0.7196 0.7195
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Trypanosoma brucei C-8 sterol isomerase, putative 0.0693 0.9711 1
Leishmania major C-8 sterol isomerase-like protein 0.0693 0.9711 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.013 0.1643 0.1769
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.2287 0.3117
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0091 0.1075 0.1156
Brugia malayi nuclear receptor RXR 0.0273 0.3696 0.3799
Echinococcus granulosus proteasome subunit beta t family 0.013 0.1643 0.1641
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0091 0.1075 0.1156
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.013 0.1643 0.1684
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0515 0.7159 0.7158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0517 0.7196 0.7407
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.013 0.1643 0.1684
Brugia malayi Phospholipase D. Active site motif family protein 0.002 0.0064 0.0055
Schistosoma mansoni phospholipase D 0.0106 0.13 0.1298
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0244 0.3276 0.3274
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0091 0.1075 0.1104
Brugia malayi nuclear receptor NHR-88 0.0244 0.3276 0.3367
Echinococcus granulosus Nuclear hormone receptor HR96 0.0244 0.3276 0.3274
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0273 0.3696 0.3694
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.013 0.1643 0.1641
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0011
Echinococcus granulosus dnaJ subfamily B 0.0422 0.5836 0.5835
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0091 0.1075 0.1156
Brugia malayi proteasome subunit beta type 1 0.0515 0.7159 0.7369
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0273 0.3696 0.3694
Brugia malayi proteasome subunit alpha type 1 0.013 0.1643 0.1684
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0515 0.7159 0.7371
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Echinococcus multilocularis Proteasome, subunit alpha beta 0.013 0.1643 0.1641
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.6668 0.6668
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.0782
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0244 0.3276 0.3274
Leishmania major proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Plasmodium vivax proteasome subunit beta type-7, putative 0.013 0.1643 0.1769
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0244 0.3276 0.3274
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0007
Echinococcus granulosus geminin 0.0175 0.2287 0.2285
Brugia malayi Cytochrome P450 family protein 0.0129 0.1623 0.1662
Loa Loa (eye worm) cytochrome P450 family protein 0.0129 0.1623 0.1662
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.013 0.1643 0.1769
Trypanosoma brucei proteasome alpha 7 subunit 0.013 0.1643 0.169
Plasmodium vivax proteasome subunit alpha type-3, putative 0.013 0.1643 0.1769
Loa Loa (eye worm) phospholipase D 0.002 0.0064 0.0055
Plasmodium vivax proteasome subunit beta type-2, putative 0.0319 0.4351 0.4687
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.013 0.1643 0.169
Echinococcus multilocularis proteasome (prosome, macropain) 0.0662 0.9279 0.9278
Echinococcus multilocularis nuclear receptor nhr 48 0.0244 0.3276 0.3274
Loa Loa (eye worm) hypothetical protein 0.0051 0.0515 0.052
Brugia malayi Proteasome A-type and B-type family protein 0.013 0.1643 0.1684
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.1641 0.1639
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0517 0.7196 0.7195
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1643 0.169
Leishmania major proteasome alpha 2 subunit, putative 0.013 0.1643 0.169
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0515 0.7159 0.7224
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0517 0.7196 0.7407
Onchocerca volvulus 0.0244 0.3276 0.4504
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.001 0.0008
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.3602 0.3703
Loa Loa (eye worm) nuclear hormone receptor 0.0244 0.3276 0.3367
Trypanosoma brucei ATP-dependent protease subunit HslV 0.013 0.1643 0.169
Brugia malayi hypothetical protein 0.0244 0.3276 0.3367
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Schistosoma mansoni hypothetical protein 0.0175 0.2287 0.2285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0517 0.7196 0.7195
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Leishmania major proteasome beta 5 subunit, putative 0.0662 0.9279 0.9554
Trypanosoma brucei cardiolipin synthetase, putative 0.0037 0.0308 0.0314
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.013 0.1643 0.1769
Mycobacterium ulcerans proteasome PrcA 0.013 0.1643 0.1769
Echinococcus multilocularis geminin 0.0175 0.2287 0.2285
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Trypanosoma brucei proteasome beta 3 subunit, putative 0.013 0.1643 0.169
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0319 0.4351 0.4478
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.013 0.1643 0.1769
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0319 0.4351 0.4349
Plasmodium falciparum proteasome subunit beta type-3, putative 0.013 0.1643 0.1769
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0017 0.002 0.0019
Giardia lamblia 20S proteasome alpha subunit 2 0.013 0.1643 0.1771
Onchocerca volvulus 0.0517 0.7196 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0319 0.4351 0.4687
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0309 0.0307
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0091 0.1075 0.1148
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0091 0.1075 0.1104
Echinococcus granulosus proteasome prosome macropain 0.0662 0.9279 0.9278
Plasmodium vivax proteasome subunit beta type-3, putative 0.013 0.1643 0.1769
Giardia lamblia 20S proteasome alpha subunit 7 0.013 0.1643 0.1771
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2422 0.102
Loa Loa (eye worm) hypothetical protein 0.0693 0.9711 1
Entamoeba histolytica hypothetical protein 0.0037 0.0309 0.033
Onchocerca volvulus Protein ultraspiracle homolog 0.0517 0.7196 1
Giardia lamblia 20S proteasome alpha subunit 4 0.013 0.1643 0.1771
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Brugia malayi Proteasome subunit alpha type 7-1 0.013 0.1643 0.1684
Schistosoma mansoni Lamin B receptor (ERG24) 0.0057 0.06 0.0597
Schistosoma mansoni hypothetical protein 0.0035 0.0281 0.0278
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0017 0.002 0.0019
Echinococcus granulosus phospholipase D 0.0094 0.1122 0.112
Brugia malayi nuclear hormone receptor 0.0244 0.3276 0.3367
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0091 0.1075 0.1156
Schistosoma mansoni thyroid hormone receptor 0.0647 0.9061 0.9061
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.013 0.1643 0.169
Loa Loa (eye worm) proteasome subunit alpha type 1 0.013 0.1643 0.1684
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0319 0.4351 0.4687
Loa Loa (eye worm) cytochrome P450 family protein 0.0091 0.1075 0.1098
Giardia lamblia 20S proteasome alpha subunit 6 0.013 0.1643 0.1771
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.013 0.1643 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0517 0.7196 0.7407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0517 0.7196 0.7195
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0517 0.7196 0.7407
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.013 0.1643 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0517 0.7196 0.7407
Echinococcus multilocularis neuropeptide s receptor 0.048 0.6668 0.6668
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0091 0.1075 0.1156
Trypanosoma cruzi cytochrome P450, putative 0.0129 0.1623 0.1668
Echinococcus multilocularis thyroid hormone receptor alpha 0.0647 0.9061 0.9061
Entamoeba histolytica phospholipase D, putative 0.0106 0.13 0.1399
Echinococcus granulosus proteasome subunit alpha type 2 0.013 0.1643 0.1641
Echinococcus granulosus proteasome subunit alpha type 6 0.013 0.1643 0.1641
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.013 0.1643 0.1769
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0091 0.1075 0.1104
Echinococcus multilocularis proteasome subunit alpha type 6 0.013 0.1643 0.1641
Schistosoma mansoni zinc finger protein 0.0244 0.3276 0.3274
Trypanosoma cruzi sterol C-24 reductase, putative 0.0057 0.06 0.0615
Loa Loa (eye worm) hypothetical protein 0.0273 0.3696 0.3799
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0515 0.7159 0.7158
Echinococcus granulosus Proteasome subunit alpha beta 0.013 0.1643 0.1641
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.013 0.1643 0.1641
Brugia malayi Nuclear hormone receptor-like 1 0.0517 0.7196 0.7407
Echinococcus multilocularis FTZ F1 alpha 0.0517 0.7196 0.7195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0517 0.7196 0.7195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0008
Onchocerca volvulus 0.0129 0.1632 0.2199
Schistosoma mansoni microtubule-associated protein tau 0.0713 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0309 0.0307
Echinococcus multilocularis subfamily T1A non peptidase ue 0.013 0.1643 0.1641
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0517 0.7196 0.7195
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.013 0.1643 0.1769
Brugia malayi CXXC zinc finger family protein 0.003 0.0202 0.0198
Leishmania major proteasome beta 3 subunit, putative 0.013 0.1643 0.169
Plasmodium vivax proteasome subunit beta type-1, putative 0.0515 0.7159 0.7715
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Echinococcus multilocularis phospholipase D1 0.0106 0.13 0.1298
Leishmania major proteasome alpha 1 subunit, putative 0.013 0.1643 0.169
Plasmodium falciparum proteasome subunit beta type-7, putative 0.013 0.1643 0.1769
Chlamydia trachomatis phospholipase D superfamily protein 0.0017 0.002 0.5
Loa Loa (eye worm) proteasome subunit beta type 3 0.013 0.1643 0.1684
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0091 0.1075 0.1148
Echinococcus multilocularis proteasome subunit beta type 7 0.013 0.1643 0.1641
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0515 0.052
Brugia malayi proteasome subunit alpha type 4 0.013 0.1643 0.1684
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.013 0.1643 0.169
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0091 0.1075 0.1156
Giardia lamblia 20S proteasome alpha subunit 1 0.013 0.1643 0.1771
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.013 0.1643 0.169
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0517 0.7196 0.7195
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0517 0.7196 0.7407
Loa Loa (eye worm) hypothetical protein 0.0559 0.7789 0.8018
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Leishmania major cytochrome p450-like protein 0.0129 0.1623 0.1668
Brugia malayi nuclear hormone receptor family member odr-7 0.0244 0.3276 0.3367
Entamoeba histolytica hypothetical protein 0.0037 0.0309 0.033
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.013 0.1643 0.1769
Echinococcus granulosus Nuclear hormone receptor HR96 0.0244 0.3276 0.3274
Loa Loa (eye worm) proteasome subunit alpha type 3 0.013 0.1643 0.1684
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0129 0.1632 0.1678
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.013 0.1643 0.1684
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0129 0.1632 0.1678
Echinococcus multilocularis cpg binding protein 0.0031 0.0226 0.0223
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0517 0.7196 0.7195
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.013 0.1643 0.1641
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0517 0.7196 0.7195
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.3602 0.3703
Brugia malayi GYF domain containing protein 0.0066 0.0719 0.0731
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0517 0.7196 0.7195
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0517 0.7196 0.7195
Entamoeba histolytica hypothetical protein 0.0037 0.0309 0.033
Schistosoma mansoni nuclear hormone receptor 0.0244 0.3276 0.3274
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0515 0.7159 0.7371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0244 0.3276 0.3274
Brugia malayi Phospholipase d protein 1 0.0106 0.13 0.133
Trypanosoma brucei proteasome beta 2 subunit, putative 0.013 0.1643 0.169
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.013 0.1643 0.1769
Brugia malayi nuclear receptor NHR-88 0.0517 0.7196 0.7407
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0662 0.9279 0.9554
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.013 0.1643 0.169
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0517 0.7196 0.7407
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0517 0.7196 0.7407
Echinococcus granulosus proteasome subunit beta type 6 0.013 0.1643 0.1641
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0517 0.7196 0.7407
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.013 0.1643 0.1641
Leishmania major proteasome beta 7 subunit, putative 0.013 0.1643 0.169
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Trypanosoma brucei proteasome beta-1 subunit, putative 0.013 0.1643 0.169
Echinococcus granulosus lamin b receptor 0.0057 0.06 0.0597
Echinococcus granulosus subfamily T1A non peptidase ue 0.013 0.1643 0.1641
Echinococcus granulosus cytochrome P450 2K1 0.0091 0.1075 0.1072
Giardia lamblia Proteasome subunit beta type 2 0.0319 0.4351 0.4689
Leishmania major hypothetical protein, conserved 0.0129 0.1632 0.1678
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.013 0.1643 0.169
Loa Loa (eye worm) hypothetical protein 0.0273 0.3696 0.3799
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1643 0.169
Loa Loa (eye worm) proteasome subunit beta type 2 0.0319 0.4351 0.4474
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0346 0.4737 0.4735
Toxoplasma gondii proteasome subunit alpha type, putative 0.013 0.1643 0.1769
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.013 0.1643 0.169
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.001 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0647 0.9061 0.9061
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0017 0.002 0.5
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.013 0.1643 0.169
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0273 0.3696 0.3694
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.013 0.1643 0.1769
Brugia malayi proteasome subunit alpha type 2 0.013 0.1643 0.1684
Plasmodium vivax proteasome subunit beta type-6, putative 0.013 0.1643 0.1769
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0517 0.7196 0.7195
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.013 0.1643 0.1641
Echinococcus granulosus neuropeptide s receptor 0.048 0.6668 0.6668
Toxoplasma gondii heat shock protein hslv, putative 0.013 0.1643 0.1769
Schistosoma mansoni cpg binding protein 0.003 0.0202 0.0199
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Leishmania major proteasome beta 2 subunit, putative 0.013 0.1643 0.169
Plasmodium vivax proteasome subunit alpha type-2, putative 0.013 0.1643 0.1769
Loa Loa (eye worm) hypothetical protein 0.0089 0.1056 0.1078
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3602 0.2566
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0008
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.013 0.1643 0.1641
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0319 0.4351 0.3546
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.013 0.1643 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0517 0.7196 0.7407
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0017 0.002 0.5
Giardia lamblia 20S proteasome alpha subunit 5 0.013 0.1643 0.1771
Schistosoma mansoni nuclear receptor nhr-48 0.0244 0.3276 0.3274
Trypanosoma brucei C-14 sterol reductase, putative 0.0057 0.06 0.0615
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Brugia malayi Nuclear hormone receptor E75 0.0244 0.3276 0.3367
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.013 0.1643 0.1641
Brugia malayi hypothetical protein 0.0273 0.3696 0.3799
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.013 0.1643 0.169
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.013 0.1643 0.1641
Brugia malayi proteasome subunit beta type 2 0.0319 0.4351 0.4474
Onchocerca volvulus 0.0066 0.0719 0.0919
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.013 0.1643 0.169
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Echinococcus granulosus neuropeptide receptor A26 0.048 0.6668 0.6668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.0007
Entamoeba histolytica proteasome subunit beta type 3, putative 0.013 0.1643 0.1769
Loa Loa (eye worm) hypothetical protein 0.0035 0.0281 0.028
Echinococcus granulosus GPCR family 2 0.0016 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0089 0.1056 0.1078
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0091 0.1075 0.1156
Giardia lamblia Proteasome subunit beta type 3 0.013 0.1643 0.1771
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1643 0.169
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.013 0.1643 0.1769
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3602 0.2566
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.013 0.1643 0.1641
Echinococcus multilocularis GPCR, family 2 0.0016 0.001 0.0007
Onchocerca volvulus 0.003 0.0202 0.0193
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0244 0.3276 0.3274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0517 0.7196 0.7407
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.013 0.1643 0.169
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.013 0.1643 0.1641
Trypanosoma brucei cytochrome P450, putative 0.0129 0.1623 0.1668
Onchocerca volvulus 0.0244 0.3276 0.4504
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0091 0.1075 0.1148
Echinococcus multilocularis microtubule associated protein 2 0.0713 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.001 0.0008
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.013 0.1643 0.1769
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0091 0.1075 0.1156
Brugia malayi Proteasome A-type and B-type family protein 0.013 0.1643 0.1684
Schistosoma mansoni cpg binding protein 0.0031 0.0226 0.0223
Echinococcus granulosus Proteasome subunit alpha type 7 0.013 0.1643 0.1641
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0091 0.1075 0.1156
Brugia malayi proteasome subunit alpha type 3 0.013 0.1643 0.1684
Brugia malayi Phospholipase D. Active site motif family protein 0.0037 0.0308 0.0307
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0515 0.7159 0.7715
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0091 0.1075 0.1148
Loa Loa (eye worm) nuclear receptor NHR-67 0.0244 0.3276 0.3367
Schistosoma mansoni nuclear hormone receptor 0.0244 0.3276 0.3274
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.013 0.1643 0.169
Loa Loa (eye worm) cytochrome P450 family protein 0.0129 0.1623 0.1662
Loa Loa (eye worm) steroid hormone receptor 0.0517 0.7196 0.7407
Schistosoma mansoni nuclear receptor 0.0244 0.3276 0.3274
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0515 0.052
Toxoplasma gondii proteasome beta subunit 0.013 0.1643 0.1769
Plasmodium vivax proteasome subunit alpha type-4, putative 0.013 0.1643 0.1769
Giardia lamblia Proteasome subunit beta type 7 precursor 0.013 0.1643 0.1771
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0091 0.1075 0.1148
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.013 0.1643 0.169
Leishmania major cardiolipin synthetase, putative 0.0017 0.002 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0281 0.028
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0091 0.1075 0.1148
Trypanosoma cruzi cytochrome P450, putative 0.0129 0.1623 0.1668
Echinococcus granulosus FTZ F1 alpha 0.0517 0.7196 0.7195
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0517 0.7196 0.7407
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0091 0.1075 0.1148
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0091 0.1075 0.1148
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1643 0.169
Plasmodium vivax proteasome subunit alpha type-1, putative 0.013 0.1643 0.1769
Brugia malayi orphan nuclear receptor NR2E1 0.0244 0.3276 0.3367
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0091 0.1075 0.1148
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0091 0.1075 0.1148
Echinococcus granulosus thyroid hormone receptor alpha 0.0244 0.3276 0.3274
Echinococcus granulosus cpg binding protein 0.0031 0.0226 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0091 0.1075 0.1148
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.013 0.1643 0.169
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.013 0.1643 0.169
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0091 0.1075 0.1156
Brugia malayi nuclear receptor NHR-67 0.0244 0.3276 0.3367
Plasmodium vivax proteasome subunit alpha type-5, putative 0.013 0.1643 0.1769
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.013 0.1643 0.1641
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0662 0.9279 0.9554
Echinococcus granulosus nuclear receptor nhr 48 0.0244 0.3276 0.3274
Schistosoma mansoni hypothetical protein 0.0037 0.0309 0.0307
Schistosoma mansoni cytochrome P450 0.0091 0.1075 0.1072
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0517 0.7196 0.7407
Brugia malayi hypothetical protein 0.0017 0.002 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.001 0.0008
Brugia malayi Cytochrome P450 family protein 0.0129 0.1623 0.1662
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.013 0.1643 0.1641
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.013 0.1643 0.1762
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0515 0.7159 0.7715
Entamoeba histolytica hypothetical protein 0.0037 0.0309 0.033
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0091 0.1075 0.1156
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0517 0.7196 0.7195
Brugia malayi ecdysone receptor 0.0244 0.3276 0.3367
Toxoplasma gondii cytochrome p450 superfamily protein 0.0091 0.1075 0.1156
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.013 0.1643 0.1769
Plasmodium falciparum proteasome subunit beta type-6, putative 0.013 0.1643 0.1769
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.013 0.1643 0.1769
Brugia malayi Nuclear hormone receptor-like 1 0.0273 0.3696 0.3799
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0517 0.7196 0.7195
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0662 0.9279 1
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.013 0.1643 0.1769
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0619 0.8656 0.8656
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.013 0.1643 0.1769
Brugia malayi nuclear hormone receptor family member nhr-6 0.0244 0.3276 0.3367
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0662 0.9279 0.9278
Brugia malayi nuclear receptor RXR 0.0244 0.3276 0.3367
Loa Loa (eye worm) CYP4Cod1 0.0129 0.1623 0.1662
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0091 0.1075 0.1148
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0091 0.1075 0.1148
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0091 0.1075 0.1148
Schistosoma mansoni hypothetical protein 0.0175 0.2287 0.2285
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0091 0.1075 0.1156
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.013 0.1643 0.1769
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Schistosoma mansoni nuclear hormone receptor 0.0517 0.7196 0.7195
Leishmania major cytochrome p450-like protein 0.0091 0.1075 0.1104
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.013 0.1643 0.169
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.013 0.1643 0.1769
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0517 0.7196 0.7195
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0244 0.3276 0.3274
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0091 0.1075 0.1148
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.013 0.1643 0.1769
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.013 0.1643 0.1641
Brugia malayi Cytochrome P450 family protein 0.0091 0.1075 0.1098
Leishmania major proteasome alpha 1 subunit, putative 0.013 0.1643 0.169
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2287 0.0843
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0202 0.0198
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.5836 0.5835
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0017 0.002 0.5
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0017 0.002 0.0018
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.013 0.1643 0.1641
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Brugia malayi photoreceptor-specific nuclear receptor 0.0517 0.7196 0.7407
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0008
Mycobacterium ulcerans proteasome PrcB 0.0662 0.9279 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.013 0.1643 0.1641
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0244 0.3276 0.4504
Echinococcus granulosus ecdysone induced protein 78C 0.0517 0.7196 0.7195
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0662 0.9279 0.9554
Schistosoma mansoni coup transcription factor 0.0517 0.7196 0.7195
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.001 0.0008
Echinococcus multilocularis 0.0091 0.1075 0.1072
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.013 0.1643 0.1769
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0662 0.9279 1
Brugia malayi Steroid receptor seven-up type 2 0.0517 0.7196 0.7407
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3602 0.2566
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.013 0.1643 0.1769
Echinococcus multilocularis Proteasome subunit alpha type 7 0.013 0.1643 0.1641
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0517 0.7196 0.7195
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0091 0.1075 0.1104
Plasmodium falciparum proteasome subunit beta type-4 0.013 0.1643 0.1769
Schistosoma mansoni steroid hormone receptor ad4bp 0.0517 0.7196 0.7195
Brugia malayi tailless protein 0.0244 0.3276 0.3367
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0515 0.7159 0.7715
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0091 0.1075 0.1148
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.001 0.0008
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.001 0.0008
Plasmodium falciparum proteasome subunit beta type-5 0.0662 0.9279 1
Plasmodium vivax proteasome subunit alpha type-6, putative 0.013 0.1643 0.1769
Trypanosoma cruzi C-14 sterol reductase, putative 0.0057 0.06 0.0615
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0017 0.002 0.5
Schistosoma mansoni hypothetical protein 0.0091 0.1075 0.1072
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0662 0.9279 1
Schistosoma mansoni nuclear receptor 0.0244 0.3276 0.3274
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0244 0.3276 0.3274
Echinococcus granulosus proteasome subunit beta type 7 0.013 0.1643 0.1641
Trypanosoma brucei Emopamil binding protein, putative 0.0129 0.1632 0.1678
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0693 0.9711 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.001 0.0008
Brugia malayi conserved hypotetical protein 0.0244 0.3276 0.3367
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3602 0.2566
Brugia malayi hypothetical protein 0.0244 0.3276 0.3367
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0037 0.0308 0.0329
Schistosoma mansoni hypothetical protein 0.0422 0.5836 0.5835
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1643 0.169
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0091 0.1075 0.1148
Echinococcus multilocularis lamin b receptor 0.0057 0.06 0.0597
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.013 0.1643 0.1641
Loa Loa (eye worm) cytochrome P450 0.0091 0.1075 0.1098
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.013 0.1643 0.1641
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.013 0.1643 0.1684
Loa Loa (eye worm) hypothetical protein 0.0517 0.7196 0.7407
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.001 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0619 0.8656 0.8656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0517 0.7196 0.7195
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0244 0.3276 0.3274
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.013 0.1643 0.1769
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0309 0.0307
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.0782
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.013 0.1643 0.169
Plasmodium vivax cardiolipin synthetase, putative 0.0017 0.002 0.0019
Trypanosoma cruzi sterol C-24 reductase, putative 0.0057 0.06 0.0615
Brugia malayi steroid hormone receptor 0.0517 0.7196 0.7407
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.0007
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.013 0.1643 0.1769
Echinococcus multilocularis proteasome subunit alpha type 2 0.013 0.1643 0.1641
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.013 0.1643 0.169
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.013 0.1643 0.169
Trypanosoma cruzi Emopamil binding protein, putative 0.0129 0.1632 0.1678
Loa Loa (eye worm) hypothetical protein 0.0273 0.3696 0.3799
Loa Loa (eye worm) proteasome subunit alpha type 2 0.013 0.1643 0.1684
Brugia malayi hypothetical protein 0.0037 0.0309 0.0309
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0515 0.052
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0662 0.9279 1
Giardia lamblia 20S proteasome alpha subunit 3 0.013 0.1643 0.1771
Echinococcus granulosus phospholipase D1 0.0106 0.13 0.1298
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0091 0.1075 0.1156
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0244 0.3276 0.4504
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0515 0.7159 0.7371
Plasmodium vivax proteasome subunit beta type-5, putative 0.0662 0.9279 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0319 0.4351 0.4349
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.013 0.1643 0.169
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0244 0.3276 0.3367
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0091 0.1075 0.1156
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0091 0.1075 0.1156
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0091 0.1075 0.1148
Brugia malayi nuclear hormone receptor 0.0517 0.7196 0.7407
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.013 0.1643 0.1769
Loa Loa (eye worm) hypothetical protein 0.0066 0.0719 0.0731
Leishmania major sterol C-24 reductase, putative 0.0057 0.06 0.0615
Trypanosoma brucei proteasome beta 7 subunit 0.013 0.1643 0.169
Leishmania major cytochrome p450-like protein 0.0091 0.1075 0.1104
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.013 0.1643 0.169
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0091 0.1075 0.1156
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0662 0.9279 1
Echinococcus granulosus phospholipase d3 0.002 0.0064 0.0061
Brugia malayi Proteasome A-type and B-type family protein 0.0662 0.9279 0.9554
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0517 0.7196 0.7195
Brugia malayi Nuclear hormone receptor-like 1 0.0273 0.3696 0.3799
Echinococcus multilocularis ecdysone induced protein 78C 0.0517 0.7196 0.7195
Leishmania major proteasome beta-1 subunit, putative 0.013 0.1643 0.169
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0693 0.9711 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0091 0.1075 0.1156
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.013 0.1643 0.1769
Schistosoma mansoni cpg binding protein 0.0031 0.0226 0.0223

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.6 nM Binding affinity towards Muscarinic acetylcholine receptor M2 ChEMBL. 12419388
Ki (binding) = 1.6 nM Binding affinity towards Muscarinic acetylcholine receptor M2 ChEMBL. 12419388
Ratio (binding) = 24 Ratio of binding affinity for muscarinic M3 receptor to muscarinic M2 receptor ChEMBL. 12419388
Ratio (binding) = 96 Ratio of binding affinity of muscarinic M1 receptor to muscarinic M2 receptor ChEMBL. 12419388
Remaining (ADMET) = 41 % Percent parent compound remaining after 20 min incubation with human liver microsomes ChEMBL. 12419388

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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