Detailed information for compound 203295

Basic information

Technical information
  • TDR Targets ID: 203295
  • Name: 5-amino-2-(4-bromophenyl)chromen-4-one
  • MW: 316.149 | Formula: C15H10BrNO2
  • H donors: 1 H acceptors: 1 LogP: 3.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1cc(=O)c2c(o1)cccc2N
  • InChi: 1S/C15H10BrNO2/c16-10-6-4-9(5-7-10)14-8-12(18)15-11(17)2-1-3-13(15)19-14/h1-8H,17H2
  • InChiKey: HFQBELSXAGCZME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-amino-2-(4-bromophenyl)-1-benzopyran-4-one
  • 5-azanyl-2-(4-bromophenyl)chromen-4-one
  • 5-amino-2-(4-bromophenyl)chromone
  • 5-amino-2-(4-bromophenyl)-4-chromenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.0486 0.0495
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0104 0.0486 0.0467
Echinococcus granulosus orexin receptor type 2 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Brugia malayi Carboxylesterase family protein 0.0344 0.2868 0.2868
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0093 0.0095
Onchocerca volvulus 0.0104 0.0486 0.0467
Onchocerca volvulus 0.0104 0.0486 0.0467
Loa Loa (eye worm) hypothetical protein 0.0241 0.1837 0.187
Loa Loa (eye worm) hypothetical protein 0.0344 0.2868 0.292
Onchocerca volvulus 0.0104 0.0486 0.0467
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0104 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Brugia malayi larval opioid receptor 0.0104 0.0486 0.0486
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.0486 0.0495
Echinococcus granulosus neuroligin 0.0058 0.0028 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0104 0.0486 0.0495
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0104 0.0486 0.0495
Echinococcus granulosus G protein coupled receptor 139 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Onchocerca volvulus 0.0104 0.0486 0.0467
Schistosoma mansoni hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.1046 0.9823 1
Schistosoma mansoni myosin xvIII 0.0104 0.0486 0.0495
Schistosoma mansoni opsin-like receptor 0.0104 0.0486 0.0495
Schistosoma mansoni neuropeptide receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus tm gpcr rhodopsin 0.1031 0.9676 0.9851
Mycobacterium tuberculosis Carboxylesterase LipT 0.0058 0.0028 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Brugia malayi Carboxylesterase family protein 0.0058 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Onchocerca volvulus 0.1046 0.9823 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0104 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Treponema pallidum sodium- and chloride- dependent transporter 0.0169 0.1128 0.5
Schistosoma mansoni biogenic amine receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Echinococcus multilocularis carboxylesterase 5A 0.0344 0.2868 0.292
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis acetylcholinesterase 0.0344 0.2868 0.292
Onchocerca volvulus 0.1046 0.9823 1
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0486 0.0495
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Echinococcus granulosus g-protein coupled receptor 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Schistosoma mansoni adenoreceptor 0.0104 0.0486 0.0495
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0028 0.0029
Onchocerca volvulus 0.0104 0.0486 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0344 0.2868 0.292
Echinococcus granulosus serotonin receptor 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0422 0.3639 0.3639
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0104 0.0486 0.0495
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0104 0.0486 0.0495
Schistosoma mansoni neuroligin 3 (S09 family) 0.0058 0.0028 0.0029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.0486 0.0495
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.0486 0.0495
Brugia malayi TspO/MBR family protein 0.1046 0.9823 0.9823
Onchocerca volvulus 0.0104 0.0486 0.0467
Schistosoma mansoni biogenic amine (5HT) receptor 0.0526 0.4663 0.4747
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis para nitrobenzyl esterase 0.0058 0.0028 0.0029
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0028 0.5
Echinococcus multilocularis sex peptide receptor 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis allatostatin A receptor 0.0104 0.0486 0.0495
Echinococcus granulosus neuropeptide receptor 0.0104 0.0486 0.0495
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Loa Loa (eye worm) acetylcholinesterase 1 0.0344 0.2868 0.292
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis neuroligin 0.0058 0.0028 0.0029
Brugia malayi G protein-coupled receptor F59B2.13 0.0104 0.0486 0.0486
Echinococcus granulosus g protein coupled receptor 0.0104 0.0486 0.0495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus carboxylesterase 5A 0.0344 0.2868 0.292
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni amine GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis g-protein coupled receptor 0.0104 0.0486 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Schistosoma mansoni hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0093 0.0095
Loa Loa (eye worm) hypothetical protein 0.0169 0.1128 0.1149
Brugia malayi G-protein coupled receptor 0.0104 0.0486 0.0486
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0486 0.0495
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0169 0.1128 0.1128
Onchocerca volvulus 0.0104 0.0486 0.0467
Brugia malayi follicle stimulating hormone receptor 0.0104 0.0486 0.0486
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0486 0.0495
Echinococcus granulosus peptide allatostatin:somatostatin 0.0104 0.0486 0.0495
Echinococcus multilocularis acetylcholinesterase 0.0344 0.2868 0.292
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Brugia malayi putative neuropeptide receptor 0.0104 0.0486 0.0486
Schistosoma mansoni opsin-like receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) melatonin receptor type 1A 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.1046 0.9823 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni acetylcholinesterase 0.0058 0.0028 0.0029
Echinococcus granulosus neuropeptide receptor A26 0.0104 0.0486 0.0495
Echinococcus multilocularis G-protein coupled receptor, putative 0.0104 0.0486 0.0495
Brugia malayi Carboxylesterase family protein 0.0058 0.0028 0.0028
Brugia malayi putative neuropeptide receptor NPR1 0.0104 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0169 0.1128 0.1149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.0486 0.0495
Echinococcus granulosus dro:myosuppressin receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0394 0.3358 0.3418
Onchocerca volvulus 0.1046 0.9823 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0104 0.0486 0.0495
Brugia malayi RE15519p 0.0104 0.0486 0.0486
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0104 0.0486 0.0486
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1031 0.9676 0.9851
Schistosoma mansoni growth hormone secretagogue receptor 0.0104 0.0486 0.0495
Onchocerca volvulus Neuropeptide F receptor homolog 0.0104 0.0486 0.0467
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.0486 0.0495
Schistosoma mansoni amine GPCR 0.0104 0.0486 0.0495
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0104 0.0486 0.0495
Echinococcus granulosus 7TM GPCR rhodopsin 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni alpha-1 adrenergic receptor 0.0104 0.0486 0.0495
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0104 0.0486 0.0495
Echinococcus granulosus BC026374 protein S09 family 0.0058 0.0028 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0104 0.0486 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Echinococcus multilocularis serotonin receptor 0.0241 0.1837 0.187
Echinococcus multilocularis fmrfamide receptor 0.0104 0.0486 0.0495
Echinococcus granulosus fmrfamide receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0093 0.0095
Loa Loa (eye worm) hypothetical protein 0.0241 0.1837 0.187
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0104 0.0486 0.0486
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.1046 0.9823 1
Brugia malayi Dopamine receptor protein 2 0.0104 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Brugia malayi Carboxylesterase family protein 0.0058 0.0028 0.0028
Echinococcus granulosus hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus neuropeptide FF receptor 2 0.0104 0.0486 0.0495
Schistosoma mansoni sodium/chloride dependent transporter 0.0169 0.1128 0.1149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0104 0.0486 0.0495
Schistosoma mansoni BC026374 protein (S09 family) 0.0058 0.0028 0.0029
Onchocerca volvulus 0.0104 0.0486 0.0467
Loa Loa (eye worm) carboxylesterase 0.0344 0.2868 0.292
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0169 0.1128 0.1123
Loa Loa (eye worm) carboxylesterase 0.0058 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus somatostatin receptor 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.1046 0.9823 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0526 0.4663 0.4747
Onchocerca volvulus 0.1046 0.9823 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0169 0.1128 0.1149
Schistosoma mansoni neuropeptide receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis G protein coupled receptor 139 0.0104 0.0486 0.0495
Schistosoma mansoni amine GPCR 0.0104 0.0486 0.0495
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0093 0.0095
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0104 0.0486 0.0486
Echinococcus multilocularis orexin receptor type 2 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0104 0.0486 0.0495
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0093 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) serotonin transporter b 0.0169 0.1128 0.1149
Schistosoma mansoni histamine h1 receptor 0.0104 0.0486 0.0495
Brugia malayi GnHR receptor homolog 0.1006 0.9428 0.9428
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0486 0.0495
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus g protein coupled receptor 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni neuropeptide receptor 0.0104 0.0486 0.0495
Brugia malayi Carboxylesterase family protein 0.0344 0.2868 0.2868
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0104 0.0486 0.0495
Brugia malayi neuropeptide F receptor 0.0104 0.0486 0.0486
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0028 0.0029
Schistosoma mansoni amine GPCR 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus acetylcholinesterase 0.0344 0.2868 0.292
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.0486 0.0495
Echinococcus granulosus allatostatin A receptor 0.0104 0.0486 0.0495
Echinococcus granulosus neuropeptide receptor 0.0104 0.0486 0.0495
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Brugia malayi Melatonin receptor type 1A 0.0104 0.0486 0.0486
Schistosoma mansoni gliotactin 0.0058 0.0028 0.0029
Echinococcus multilocularis neuropeptide s receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis serotonin receptor 0.0241 0.1837 0.187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Brugia malayi Carboxylesterase family protein 0.0058 0.0028 0.0028
Brugia malayi Dopamine receptor protein 1 0.0104 0.0486 0.0486
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.1837 0.187
Echinococcus granulosus serotonin transporter 0.0169 0.1128 0.1149
Brugia malayi G protein-coupled receptor 0.0104 0.0486 0.0486
Onchocerca volvulus 0.0104 0.0486 0.0467
Echinococcus granulosus para nitrobenzyl esterase 0.0058 0.0028 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.0486 0.0495
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0093 0.5
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0058 0.0028 0.0029
Echinococcus multilocularis BC026374 protein (S09 family) 0.0058 0.0028 0.0029
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) carboxylesterase 0.0058 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis neuropeptide receptor A26 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Echinococcus granulosus 7tm_1 domain containing protein 0.0104 0.0486 0.0495
Echinococcus multilocularis fmrfamide receptor 0.0104 0.0486 0.0495
Schistosoma mansoni neuropeptide receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0104 0.0486 0.0495
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0058 0.0028 0.0029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0104 0.0486 0.0486
Schistosoma mansoni biogenic amine receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0104 0.0486 0.0495
Echinococcus granulosus neuropeptide s receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0486 0.0495
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0486 0.0495
Brugia malayi AKH receptor 0.0104 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Brugia malayi neuropeptide F receptor 0.0104 0.0486 0.0486
Trichomonas vaginalis spcc417.12 protein, putative 0.0058 0.0028 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0028 0.0029
Brugia malayi Dopamine receptor 0.0104 0.0486 0.0486
Echinococcus granulosus acetylcholinesterase 0.0344 0.2868 0.292
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.1837 0.187
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0093 0.5
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0093 0.5
Loa Loa (eye worm) hypothetical protein 0.0344 0.2868 0.292
Echinococcus granulosus sex peptide receptor 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0104 0.0486 0.0495
Mycobacterium ulcerans tryptophan-rich sensory protein 0.1046 0.9823 1
Schistosoma mansoni hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus translocator protein 0.1046 0.9823 1
Brugia malayi G-protein coupled receptor 0.0104 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Brugia malayi Serotonin receptor 0.0104 0.0486 0.0486
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0526 0.4663 0.4747
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0093 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0169 0.1128 0.1149
Loa Loa (eye worm) TYRA-2 protein 0.0104 0.0486 0.0495
Schistosoma mansoni neuropeptide f receptor 76f 0.0104 0.0486 0.0495
Schistosoma mansoni biogenic amine receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Schistosoma mansoni hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0104 0.0486 0.0495
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0028 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0104 0.0486 0.0495
Brugia malayi ORL1-like opioid receptor 0.0104 0.0486 0.0486
Loa Loa (eye worm) norepinephrine transporter 0.0169 0.1128 0.1149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Schistosoma mansoni amine GPCR 0.0104 0.0486 0.0495
Onchocerca volvulus 0.0104 0.0486 0.0467
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus alpha 1A adrenergic receptor 0.0104 0.0486 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Echinococcus granulosus g protein coupled receptor 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.1046 0.9823 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0169 0.1128 0.1149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Brugia malayi sulfakinin receptor protein 0.0104 0.0486 0.0486
Echinococcus multilocularis serotonin transporter 0.0169 0.1128 0.1149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus granulosus tachykinin peptides receptor 99D 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0104 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0028 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.0486 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0486 0.0495
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0104 0.0486 0.0495
Schistosoma mansoni opsin-like receptor 0.0104 0.0486 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0486 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.0486 0.0495
Echinococcus multilocularis translocator protein 0.1046 0.9823 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0104 0.0486 0.0495
Echinococcus multilocularis somatostatin receptor 0.0104 0.0486 0.0495
Brugia malayi hypothetical protein 0.0058 0.0028 0.0028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.0486 0.0495
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0058 0.0028 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1 uM Anti-proliferative activity against estrogen-responsive human breast cancer cell line MCF-7 in the presence of ER at a 10e-4 microM concentration of estradiol ChEMBL. 8784443
IC50 (functional) = 1 uM Anti-proliferative activity against estrogen-responsive human breast cancer cell line MCF-7 in the presence of ER at a 10e-4 microM concentration of estradiol ChEMBL. 8784443
IC50 (functional) = 9.5 uM Inhibition of 10e-4 uM estradiol induced estrogen receptor positive MCF-7 human breast cancer cell proliferation ChEMBL. 8784443
IC50 (functional) = 9.5 uM Inhibition of 10e-4 uM estradiol induced estrogen receptor positive MCF-7 human breast cancer cell proliferation ChEMBL. 8784443
IC50 (binding) > 100 uM Binding affinity for estrogen receptor, by competition with [3H]-estradiol ChEMBL. 8784443
IC50 (binding) > 100 uM Binding affinity for estrogen receptor, by competition with [3H]-estradiol ChEMBL. 8784443

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8784443

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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