Detailed information for compound 203419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.513 | Formula: C23H24N2O4S
  • H donors: 2 H acceptors: 4 LogP: 3.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)Cc1ccccc1)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)O)(C)C
  • InChi: 1S/C23H24N2O4S/c1-23(2)18(22(28)29)25-20(27)17(21(25)30-23)24-19(26)16(15-11-7-4-8-12-15)13-14-9-5-3-6-10-14/h3-12,16-18,21H,13H2,1-2H3,(H,24,26)(H,28,29)/t16?,17-,18+,21-/m1/s1
  • InChiKey: DIKGUXXWBNNDMD-GKTUAVMOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.1127 1
Schistosoma mansoni hypothetical protein 0.035 0.1411 0.2454
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0091 0.0619
Echinococcus granulosus intermediate filament protein 0.0027 0.0055 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0068 0.023
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0065 0.0108
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0105 0.0502
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0903 0.7971
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0068 0.066
Brugia malayi nuclear receptor NHR-88 0.003 0.0068 0.023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0207 0.036
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0252 0.1399
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0068 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0372 0.1502 0.15
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0068 0.0066
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0252 0.2081
Schistosoma mansoni hypothetical protein 0.057 0.2331 0.4056
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0105 0.0385 0.0382
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0039 0.0331
Leishmania major hypothetical protein, conserved 0.0025 0.005 0.0167
Echinococcus multilocularis histone acetyltransferase MYST2 0.0105 0.0385 0.0382
Entamoeba histolytica hypothetical protein 0.0023 0.0039 0.015
Mycobacterium tuberculosis Conserved protein 0.0047 0.0142 0.2405
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0045 0.0074
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0065 0.0062
Trypanosoma brucei polo-like protein kinase 0.0091 0.0326 0.185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0055 0.0186
Onchocerca volvulus 0.0074 0.0252 0.2511
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.005 0.0515
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.012 0.089
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.019 0.7081
Onchocerca volvulus 0.008 0.0281 0.2798
Brugia malayi Pre-SET motif family protein 0.0201 0.0786 0.265
Brugia malayi nuclear hormone receptor 0.003 0.0068 0.023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0068 0.0114
Entamoeba histolytica hypothetical protein 0.0107 0.0392 0.335
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0068 0.0114
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0252 0.1399
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0252 0.1399
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0092
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0068 0.023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0105 0.0102
Schistosoma mansoni smad1 5 8 and 0.0024 0.0045 0.0074
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0252 0.2081
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0047 0.0142 0.2405
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0544 0.1833
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0091 0.0416
Brugia malayi Pre-SET motif family protein 0.0029 0.0065 0.0218
Brugia malayi nuclear receptor RXR 0.0014 0.0003 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0068 0.0066
Brugia malayi nuclear receptor RXR 0.0016 0.001 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.005 0.0515
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.005 0.0515
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0326 0.3259
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0105 0.0746
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.012 0.3832
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0068 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0411 0.1666 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0074 0.0252 0.1399
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.1127 1
Echinococcus granulosus aminopeptidase N 0.0074 0.0252 0.0435
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0068 0.023
Echinococcus multilocularis Smad4 0.0024 0.0045 0.0043
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0326 0.2753
Echinococcus multilocularis smad 0.0024 0.0045 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.019 0.3355
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0068 0.023
Brugia malayi Smad1 0.0024 0.0045 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0068 0.0119
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0017
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0522 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0074 0.0252 0.0435
Echinococcus multilocularis GPCR, family 2 0.0063 0.0207 0.0204
Brugia malayi hypothetical protein 0.0251 0.0996 0.3356
Schistosoma mansoni ap endonuclease 0.0038 0.0105 0.0178
Schistosoma mansoni hypothetical protein 0.0063 0.0207 0.0355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0511 0.0886
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0522 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0252 0.025
Onchocerca volvulus 0.0074 0.0252 0.2511
Onchocerca volvulus Huntingtin homolog 0.0251 0.0996 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0074 0.0252 0.1399
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0511 0.089
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0055 0.0096
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0326 0.0564
Onchocerca volvulus Huntingtin homolog 0.0251 0.0996 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0392 0.0679
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0252 0.0435
Echinococcus multilocularis lamin dm0 0.0027 0.0055 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0068 0.0119
Echinococcus granulosus lamin 0.0027 0.0055 0.0092
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0209 0.0365
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0022 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0207 0.0696
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0133 0.1006
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0209 0.036
Loa Loa (eye worm) hypothetical protein 0.008 0.0281 0.0488
Brugia malayi MH2 domain containing protein 0.0024 0.0045 0.0153
Schistosoma mansoni hypothetical protein 0.0063 0.0207 0.0355
Schistosoma mansoni hypothetical protein 0.035 0.1411 0.2454
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Echinococcus granulosus histone acetyltransferase MYST2 0.0105 0.0385 0.0666
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0068 0.023
Brugia malayi TATA binding protein associated factor 0.0074 0.0252 0.0849
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.019 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.001 0.0012
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.001 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0068 0.0114
Loa Loa (eye worm) hypothetical protein 0.0251 0.0996 0.1735
Schistosoma mansoni survival motor neuron protein 0.0147 0.0561 0.0972
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0045 0.0079
Onchocerca volvulus 0.0092 0.0331 0.3308
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0068 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.019 0.3355
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0055 0.0096
Schistosoma mansoni thyroid hormone receptor 0.003 0.0068 0.0114
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Brugia malayi mbt repeat family protein 0.0092 0.0331 0.1116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0068 0.0066
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0091 0.243
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0252 0.0849
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0068 0.0114
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0281 0.0945
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0003 0.0009
Brugia malayi hypothetical protein 0.0636 0.261 0.8794
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.001 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0511 0.0509
Brugia malayi MH1 domain containing protein 0.0024 0.0045 0.0153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0996 0.1735
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0039 0.0331
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0252 0.1399
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0106 0.0757
Trypanosoma cruzi Aminopeptidase M1, putative 0.0074 0.0252 0.1399
Schistosoma mansoni sex comb on midleg homolog 0.0092 0.0331 0.0573
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0092 0.0331 0.0577
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0065 0.1227
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0252 0.1399
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0091 0.0619
Brugia malayi hypothetical protein 0.0014 0.0003 0.0009
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0252 0.2081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0065 0.0108
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1384 0.5743 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0252 0.1399
Loa Loa (eye worm) acetyltransferase 0.0143 0.0544 0.0947
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0252 0.0435
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0003 0.0004
Onchocerca volvulus 0.0029 0.0065 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0068 0.023
Schistosoma mansoni sex comb on midleg homolog 0.0092 0.0331 0.0573
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0105 0.0502
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0045 0.0074
Loa Loa (eye worm) TATA binding protein associated factor 0.0074 0.0252 0.0439
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.002
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0003 0.0009
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0047 0.0142 0.0731
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0096
Onchocerca volvulus 0.0027 0.0055 0.0529
Brugia malayi nuclear hormone receptor 0.0014 0.0003 0.0009
Mycobacterium ulcerans hypothetical protein 0.0047 0.0142 0.2405
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.1127 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0022 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0392 0.0679
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0105 0.0182
Onchocerca volvulus 0.0027 0.0055 0.0529
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0252 0.0849
Toxoplasma gondii aminopeptidase n, putative 0.0074 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0385 0.067
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0045 0.0043
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0105 0.0746
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.005 0.0515
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0091 0.0158
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0527 0.0914
Schistosoma mansoni hypothetical protein 0.0147 0.0561 0.0972
Brugia malayi RNA binding protein 0.0063 0.0209 0.0706
Schistosoma mansoni myelin transcription factor 1 myt1 0.0105 0.0385 0.0666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0068 0.0119
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0105 0.0352
Mycobacterium ulcerans hypothetical protein 0.0047 0.0142 0.2405
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0047 0.0142 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0068 0.023
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0326 0.0568
Echinococcus multilocularis polycomb protein SCMH1 0.0092 0.0331 0.0329
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0252 0.0435
Onchocerca volvulus 0.0074 0.0252 0.2511
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0281 0.0484
Brugia malayi hypothetical protein 0.0025 0.005 0.0167
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0022 0.0034
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0392 0.039
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0068 0.023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0068 0.0114
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0045 0.0074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0105 0.0606
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0017
Echinococcus granulosus Smad4 0.0024 0.0045 0.0074
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0074 0.0252 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0045 0.0043
Brugia malayi hypothetical protein 0.0016 0.0012 0.0041
Echinococcus granulosus survival motor neuron protein 1 0.0722 0.2968 0.5166
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0047 0.0142 0.2405
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0209 0.036
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0281 0.0278
Schistosoma mansoni kinase 0.0046 0.0138 0.0236
Echinococcus granulosus transcription factor btf3 0.0035 0.0091 0.0153
Loa Loa (eye worm) MBCTL1 0.0105 0.0385 0.067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0038
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0068 0.0066
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0544 0.0943
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0091 0.243
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Brugia malayi hypothetical protein 0.0016 0.001 0.0032
Schistosoma mansoni nuclear hormone receptor 0.003 0.0068 0.0114
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0068 0.066
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0105 0.3089
Schistosoma mansoni smad1 5 8 and 0.0024 0.0045 0.0074
Schistosoma mansoni smad1 5 8 and 0.0024 0.0045 0.0074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0068 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0017
Echinococcus granulosus dna polymerase eta 0.0019 0.0022 0.0034
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0022 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0209 0.036
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0074 0.0252 0.025
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0326 0.0324
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0522 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0065 0.1227
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.001 0.0032
Onchocerca volvulus 0.003 0.0068 0.066
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0091 0.0416
Brugia malayi hypothetical protein 0.0074 0.0252 0.0849
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0105 0.3089
Toxoplasma gondii aminopeptidase N, putative 0.0074 0.0252 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0511 0.0886
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0074 0.0252 0.0435
Echinococcus granulosus leukotriene A 4 hydrolase 0.1384 0.5743 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.0774 0.1348
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Echinococcus granulosus FTZ F1 alpha 0.003 0.0068 0.0114
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0147 0.0561 0.1889
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0252 0.025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0105 0.0502
Echinococcus granulosus dna polymerase kappa 0.0019 0.0022 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Schistosoma mansoni ap endonuclease 0.0038 0.0105 0.0178
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.0439
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0003 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0068 0.0119
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0105 1
Echinococcus multilocularis aminopeptidase N 0.0074 0.0252 0.025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0068 0.023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0065 0.0108
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0252 0.0849
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0106 0.0757
Echinococcus multilocularis citrate lyase subunit beta protein 0.0047 0.0142 0.014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.019 0.102
Echinococcus granulosus SAM and MBT domain containing protein 0.0092 0.0331 0.0573
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0068 0.0119
Brugia malayi hypothetical protein 0.0016 0.001 0.0032
Entamoeba histolytica hypothetical protein 0.0107 0.0392 0.335
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0065 0.0108
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.005 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0068 0.023
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0074 0.0252 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0065 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0068 0.0114
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0281 0.0484
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.0439
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0045 0.0079
Entamoeba histolytica hypothetical protein 0.0107 0.0392 0.335
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0092 0.0331 0.0573
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0068 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0105 0.0746
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0209 0.0365
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.019 0.3355
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0105 0.0385 0.0666
Brugia malayi hypothetical protein 0.0722 0.2968 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0068 0.023
Brugia malayi steroid hormone receptor 0.003 0.0068 0.023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0068 0.0066
Entamoeba histolytica hypothetical protein 0.0107 0.0392 0.335
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0326 0.2753
Schistosoma mansoni thyroid hormone receptor 0.003 0.0068 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Entamoeba histolytica aminopeptidase, putative 0.0074 0.0252 0.2081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0207 0.0355
Schistosoma mansoni hypothetical protein 0.0107 0.0392 0.0679
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.0439
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.019 0.0326
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0209 0.0706
Echinococcus multilocularis lamin 0.0027 0.0055 0.0053
Brugia malayi nuclear receptor NHR-88 0.0014 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0252 0.1399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Trypanosoma brucei aminopeptidase, putative 0.0074 0.0252 0.1399
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0511 0.0509
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0252 0.4601
Loa Loa (eye worm) RNA binding protein 0.0063 0.0209 0.0365
Echinococcus multilocularis transcription factor btf3 0.0035 0.0091 0.0088
Echinococcus multilocularis geminin 0.035 0.1411 0.1409
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0105 0.0385 0.1297
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0209 0.036
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0252 0.1399
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.005 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0411 0.1666 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0068 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0003 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0105 0.165
Brugia malayi mbt repeat family protein 0.0092 0.0331 0.1116
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0039 0.0101
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0252 0.025
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.019 0.0326
Onchocerca volvulus 0.0147 0.0561 0.5618
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.0774 0.2608
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0252 0.1399
Loa Loa (eye worm) hypothetical protein 0.0063 0.0207 0.036
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0209 0.036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0252 0.1399
Brugia malayi MH2 domain containing protein 0.0355 0.143 0.482
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.012 0.3832
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0105 0.0746
Schistosoma mansoni transcription factor btf3 0.0035 0.0091 0.0153
Schistosoma mansoni hypothetical protein 0.0063 0.0207 0.0355
Schistosoma mansoni lamin 0.0027 0.0055 0.0092
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0022 0.0034
Echinococcus granulosus lamin dm0 0.0027 0.0055 0.0092
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0068 0.0114
Echinococcus multilocularis musashi 0.0027 0.0055 0.0053
Toxoplasma gondii aminopeptidase N protein 0.0074 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.0774 0.1348
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0544 0.0542
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.143 0.2491
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0004 0.0006
Brugia malayi hypothetical protein 0.0107 0.0392 0.1322
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0047 0.0142 0.2405
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.0086
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0091 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0003 0.0009
Brugia malayi conserved hypotetical protein 0.0014 0.0003 0.0009
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0047 0.0142 0.2405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0207 0.0355
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0326 0.11
Loa Loa (eye worm) aminopeptidase N 0.0074 0.0252 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0326 0.0564
Echinococcus granulosus geminin 0.035 0.1411 0.2454
Brugia malayi hypothetical protein 0.0074 0.0252 0.0849
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.001 0.0032
Giardia lamblia Kinase, PLK 0.0091 0.0326 0.2753
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.0511 0.1723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0105 0.0502
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.012 0.3832
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0786 0.1369
Brugia malayi beta-NAC-like protein 0.0035 0.0091 0.0305
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0106 0.3144
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0074 0.0252 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0039 0.0101
Brugia malayi MH2 domain containing protein 0.0024 0.0045 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0133 0.1006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0511 0.0886
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.012 0.0205
Loa Loa (eye worm) hypothetical protein 0.0135 0.0511 0.0891
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0047 0.0142 0.0731
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0252 0.1399
Leishmania major basic transcription factor 3a, putative 0.0035 0.0091 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0722 0.2968 0.5168
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0326 0.185
Schistosoma mansoni Smad4 0.0024 0.0045 0.0074
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0252 0.0435
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0209 0.0207
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.143 0.2491
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0091 0.243
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0068 0.0119
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0092 0.0331 0.3308
Brugia malayi TAR-binding protein 0.0063 0.0209 0.0706
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0105 0.165
Echinococcus granulosus polycomb protein SCMH1 0.0092 0.0331 0.0573
Brugia malayi intermediate filament protein 0.0027 0.0055 0.0186
Echinococcus granulosus smad 0.0024 0.0045 0.0074
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0068 0.0114
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0326 0.185
Echinococcus multilocularis dna polymerase eta 0.0019 0.0022 0.002
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0252 0.0435
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0252 0.0435
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0105 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0068 0.023
Echinococcus granulosus citrate lyase subunit beta protein 0.0047 0.0142 0.0243
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0252 0.4601
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.1127 1
Brugia malayi ecdysone receptor 0.0014 0.0003 0.0009
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.001 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0068 0.023
Schistosoma mansoni hypothetical protein 0.0063 0.0207 0.0355
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Onchocerca volvulus 0.0229 0.0903 0.906
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0017
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0252 0.025
Schistosoma mansoni intermediate filament proteins 0.0027 0.0055 0.0092
Brugia malayi tailless protein 0.0014 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0003 0.0009
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0047 0.0142 0.1088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0207 0.0204
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0004 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0068 0.066
Leishmania major hypothetical protein, conserved 0.0411 0.1666 1
Loa Loa (eye worm) Smad1 0.0024 0.0045 0.0079
Echinococcus granulosus tar DNA binding protein 0.0063 0.0209 0.036
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0252 0.025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Loa Loa (eye worm) DR-78 0.0014 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0119
Schistosoma mansoni lamin 0.0027 0.0055 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0068 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0068 0.0119
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1384 0.5743 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.006 0.0101
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.019 0.3355
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0068 0.0114
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0326 0.185
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0372 0.1502 0.2613
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0511 0.0886
Echinococcus granulosus GPCR family 2 0.0063 0.0207 0.0355
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0074 0.0252 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0068 0.0066
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0039 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0068 0.0066
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0074 0.0252 0.0435
Echinococcus multilocularis survival motor neuron protein 1 0.0722 0.2968 0.2966
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0207 0.0696
Schistosoma mansoni smad 0.0024 0.0045 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.005 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1127 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0068 0.023
Echinococcus multilocularis SAM and MBT domain containing protein 0.0092 0.0331 0.0329
Brugia malayi hypothetical protein 0.0014 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0511 0.0886
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.019 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0113
Loa Loa (eye worm) peptidase family M1 containing protein 0.0074 0.0252 0.0439
Brugia malayi ecdysteroid receptor 0.003 0.0068 0.023
Schistosoma mansoni hypothetical protein 0.0135 0.0511 0.0886
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0074 0.0252 0.0435
Brugia malayi MH1 domain containing protein 0.0024 0.0045 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0068 0.023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0068 0.023
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0039 0.0331
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0511 0.1723
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0207 0.0204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0068 0.0114
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0068 0.0114
Schistosoma mansoni coup transcription factor 0.003 0.0068 0.0114
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1384 0.5743 0.5742
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0065 0.0062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0068 0.0114
Brugia malayi nuclear receptor NHR-67 0.0014 0.0003 0.0009
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.012 0.089
Toxoplasma gondii exonuclease III APE 0.0038 0.0105 0.3089
Loa Loa (eye worm) mbt repeat family protein 0.0092 0.0331 0.0577
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.0774 0.2608
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0074
Trypanosoma brucei hypothetical protein, conserved 0.0411 0.1666 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0252 0.1399

Activities

Activity type Activity value Assay description Source Reference
T1/2 (ADMET) = 7000 min Hydrolysis half life of the compound using immobilized penicillin-G acylase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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