Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thioredoxin reductase | 0.00765949 | 1 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.00765949 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.00765949 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.00265424 | 0.123389 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00265424 | 0.123389 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.00265424 | 0.123389 | 0.123389 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.00265424 | 0.123389 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.00765949 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.00765949 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00265424 | 0.123389 | 0.5 |
Leishmania major | trypanothione reductase | 0.00765949 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.00765949 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.00265424 | 0.123389 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.00765949 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00265424 | 0.123389 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.00765949 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.00765949 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00265424 | 0.123389 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.00765949 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.00265424 | 0.123389 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00265424 | 0.123389 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00265424 | 0.123389 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.00765949 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.00765949 | 1 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.00765949 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00265424 | 0.123389 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.00765949 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.00765949 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.00765949 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.00265424 | 0.123389 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.00765949 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.00765949 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.00765949 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.00265424 | 0.123389 | 0.123389 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.00265424 | 0.123389 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.00765949 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00265424 | 0.123389 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.00765949 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00265424 | 0.123389 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00265424 | 0.123389 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.00765949 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.00765949 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.00765949 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.00765949 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00265424 | 0.123389 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.00265424 | 0.123389 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.00265424 | 0.123389 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00265424 | 0.123389 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.00265424 | 0.123389 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.00265424 | 0.123389 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.00765949 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.00765949 | 1 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.00765949 | 1 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.00765949 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.01 uM | Inhibitory concentration of the compound against T. vaginalis (tv-43) for anti-trichomonal activity | ChEMBL. | 12419387 |
IC50 (functional) | = 6.01 uM | Inhibitory concentration of the compound against T. vaginalis (tv-43) for anti-trichomonal activity | ChEMBL. | 12419387 |
IC50 (functional) | = 8.03 uM | Inhibitory concentration of the compound against G. Lamblia (IMSS-0989) for antigiardial activity | ChEMBL. | 12419387 |
IC50 (functional) | = 10.1 uM | Inhibitory concentration of the compound against E. histolytica (HK-9) for antiamoebic activity | ChEMBL. | 12419387 |
IC50 (functional) | = 10.1 uM | Inhibitory concentration of the compound against E. histolytica (HK-9) for antiamoebic activity | ChEMBL. | 12419387 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trichomonas vaginalis | ChEMBL23 | 12419387 | |
Entamoeba histolytica | ChEMBL23 | 12419387 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.