TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.422 | Formula: C22H24O7
H donors: 1 H acceptors: 1 LogP: 2.46 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1[C@@H]2CO[C@@]1(c1cc(OC)c(c(c1)OC)OC)c1c(C2)cc2c(c1)OCO2
InChi: 1S/C22H24O7/c1-24-19-6-14(7-20(25-2)21(19)26-3)22-15-8-18-17(27-11-28-18)5-12(15)4-13(10-29-22)16(22)9-23/h5-8,13,16,23H,4,9-11H2,1-3H3/t13-,16-,22-/m0/s1
InChiKey: QJUAJRMLIMHQCQ-ODIUBACGSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2875	0.6031
Mycobacterium ulcerans	lipase LipD	0.0036	0.003	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.003	0.0062
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.4768	1
Leishmania major	cysteine peptidase A (CPA)	0.0127	0.4768	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.4768	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0127	0.4768	1
Leishmania major	hypothetical protein, conserved	0.0036	0.003	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0085	0.259	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0036	0.003	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.259	0.5403
Trypanosoma cruzi	cruzipain precursor, putative	0.0042	0.0358	0.075
Schistosoma mansoni	cathepsin F (C01 family)	0.0085	0.259	0.5432
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Plasmodium vivax	unspecified product	0.0065	0.1573	0.33
Trypanosoma cruzi	cysteine proteinase, putative	0.0065	0.1573	0.33
Trypanosoma cruzi	cysteine proteinase, putative	0.0065	0.1573	0.33
Plasmodium vivax	vivapain-2	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1573	0.3258
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0085	0.259	0.5432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0127	0.4768	1
Brugia malayi	Papain family cysteine protease containing protein	0.0065	0.1573	0.33
Brugia malayi	beta-lactamase family protein	0.0036	0.003	0.0062
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.003	0.5
Onchocerca volvulus		0.0127	0.4768	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0729	0.153
Entamoeba histolytica	cysteine proteinase, putative	0.0085	0.259	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Onchocerca volvulus		0.0085	0.259	0.5432
Trypanosoma cruzi	cysteine protease, putative	0.0065	0.1573	0.33
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0065	0.1573	0.33
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Onchocerca volvulus		0.0127	0.4768	1
Brugia malayi	Cathepsin L-like precursor	0.0127	0.4768	1
Plasmodium vivax	vivapain-3	0.0065	0.1573	0.33
Brugia malayi	cathepsin L-like precursor	0.0085	0.259	0.5432
Mycobacterium leprae	Probable lipase LipE	0.0036	0.003	0.5
Brugia malayi	Cathepsin L-like precursor	0.0085	0.259	0.5432
Brugia malayi	Cathepsin L-like precursor	0.0127	0.4768	1
Entamoeba histolytica	cysteine protease, putative	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0127	0.4768	1
Echinococcus granulosus	cathepsin l1	0.0127	0.4768	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.003	0.0062
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0729	0.153
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Onchocerca volvulus		0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0358	0.075
Loa Loa (eye worm)	hypothetical protein	0.0036	0.003	0.0062
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2875	0.6031
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.259	0.5432
Echinococcus multilocularis	cysteine protease	0.0127	0.4768	1
Onchocerca volvulus		0.0036	0.003	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0358	0.075
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0127	0.4768	1
Plasmodium vivax	vivapain-2	0.0127	0.4768	1
Onchocerca volvulus		0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Onchocerca volvulus	Cathepsin L homolog	0.0127	0.4768	1
Brugia malayi	Papain family cysteine protease containing protein	0.0065	0.1573	0.33
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.003	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Echinococcus multilocularis	cysteine protease	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.259	0.5432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Echinococcus granulosus	cysteine protease	0.0065	0.1573	0.33
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.1573	0.33
Schistosoma mansoni	cathepsin s	0.0042	0.0358	0.075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0065	0.1573	0.3258
Echinococcus granulosus	cathepsin L	0.0065	0.1573	0.33
Onchocerca volvulus	Cathepsin F homolog	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0127	0.4768	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.003	0.0062
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.003	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.4768	1
Brugia malayi	beta-lactamase	0.0036	0.003	0.0062
Mycobacterium ulcerans	beta-lactamase	0.0036	0.003	0.5
Onchocerca volvulus		0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.003	0.0062
Mycobacterium ulcerans	hypothetical protein	0.0036	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.003	0.0062
Brugia malayi	Cathepsin L-like precursor	0.0127	0.4768	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.003	0.0062
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.1573	0.33
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2875	0.6031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.259	0.5403
Loa Loa (eye worm)	cysteine protease	0.0127	0.4768	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2875	0.6031
Onchocerca volvulus		0.0127	0.4768	1
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2875	0.6031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.4768	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Loa Loa (eye worm)	ctsf protein	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Brugia malayi	Cathepsin L-like precursor	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.003	0.0062
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.1573	0.33
Brugia malayi	Cathepsin L-like precursor	0.0042	0.0358	0.075
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0042	0.0358	0.075
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.003	0.0062
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1573	0.33
Plasmodium vivax	unspecified product	0.0042	0.0358	0.075
Trypanosoma cruzi	cruzipain precursor, putative	0.0127	0.4768	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2875	0.6031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1573	0.3258
Loa Loa (eye worm)	hypothetical protein	0.0036	0.003	0.0062
Echinococcus granulosus	cathepsin l1	0.0085	0.259	0.5432
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.003	0.0062
Brugia malayi	Cathepsin L-like precursor	0.0085	0.259	0.5432
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.003	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.2875	0.6031
Echinococcus multilocularis	cathepsin L cysteine protease	0.0127	0.4768	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0065	0.1573	0.33
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0729	0.153
Onchocerca volvulus	Cathepsin L homolog	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0127	0.4768	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.003	0.0062
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0042	0.0358	0.075
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.2875	0.6031
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0127	0.4768	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0042	0.0358	0.075
Onchocerca volvulus		0.0036	0.003	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2875	0.6031
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.003	0.0062
Plasmodium vivax	vivapain-1	0.0065	0.1573	0.33
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.4768	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0042	0.0358	0.075
Brugia malayi	Cathepsin L-like precursor	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0729	0.153
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.4768	1
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Toxoplasma gondii	cathepsin CPL	0.0127	0.4768	1
Brugia malayi	beta-lactamase family protein	0.0036	0.003	0.0062
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0127	0.4768	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0127	0.4768	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.003	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0065	0.1573	0.3258
Loa Loa (eye worm)	fibroinase	0.0127	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0358	0.075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0065	0.1573	0.33
Onchocerca volvulus		0.0036	0.003	0.0062
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.4768	1
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Echinococcus multilocularis	cathepsin L	0.0065	0.1573	0.33
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0085	0.259	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0036	0.003	0.0062
Leishmania major	cathepsin L-like protease	0.0127	0.4768	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.4768	1
Onchocerca volvulus		0.0127	0.4768	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0127	0.4768	1
Brugia malayi	Cathepsin L-like precursor	0.0127	0.4768	1

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= -6.53	Cytotoxicity against breast MDA-MB-435 cell line	ChEMBL.	12646028
GI50 (functional)	= -6.23	Cytotoxicity against leukemia SR cell line	ChEMBL.	12646028
GI50 (functional)	= -5.84	Cytotoxicity against ovarian OVCAR-3 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.6	Cytotoxicity against CNS SF-539 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.58	Cytotoxicity against prostate DU-145 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.57	Cytotoxicity against prostate CNS SNB-75 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.54	Cytotoxicity against colon HCT-116 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.39	Mean graph midpoint for growth inhibition of all human cancer cell lines.	ChEMBL.	12646028
GI50 (functional)	= -5.37	Cytotoxicity against melanoma UACC-62 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.36	Cytotoxicity against lung HOP-62 cell line	ChEMBL.	12646028
GI50 (functional)	= -5.21	Cytotoxicity against lung NCI-322M cell line	ChEMBL.	12646028
GI50 (functional)	= -4.63	Cytotoxicity against prostate ovarian OVCAR-4 cell line	ChEMBL.	12646028
GI50 (functional)	= -1.14	Delta is the logarithm difference between the mean graph midpoint and the most sensitive cell line	ChEMBL.	12646028
GI50 (functional)	= 2.53	Range is the logarithm difference between the log GI50 of the most resistant and the most sensitive cell lines	ChEMBL.	12646028
GI50 (functional)	= 58	Cytotoxicity against human cell lines were determined	ChEMBL.	12646028
Log GI50 (functional)	0	Cytotoxicity against renal SN12C cell line; Not tested	ChEMBL.	12646028
Log GI50 (functional)	= -6.53 M	Cytotoxicity against breast MDA-MB-435 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -6.23 M	Cytotoxicity against leukemia SR cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.84 M	Cytotoxicity against ovarian OVCAR-3 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.6 M	Cytotoxicity against CNS SF-539 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.58 M	Cytotoxicity against prostate DU-145 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.57 M	Cytotoxicity against prostate CNS SNB-75 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.54 M	Cytotoxicity against colon HCT-116 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.39 M	Mean graph midpoint for growth inhibition of all human cancer cell lines.	ChEMBL.	12646028
Log GI50 (functional)	= -5.37 M	Cytotoxicity against melanoma UACC-62 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.36 M	Cytotoxicity against lung HOP-62 cell line	ChEMBL.	12646028
Log GI50 (functional)	= -5.21 M	Cytotoxicity against lung NCI-322M cell line	ChEMBL.	12646028
Log GI50 (functional)	= -4.63 M	Cytotoxicity against prostate ovarian OVCAR-4 cell line	ChEMBL.	12646028
Log GI50 (functional)	= 1.14 M	Delta is the logarithm difference between the mean graph midpoint and the most sensitive cell line	ChEMBL.	12646028
Log GI50 (functional)	= 2.53 M	Range is the logarithm difference between the log GI50 of the most resistant and the most sensitive cell lines	ChEMBL.	12646028
Log GI50 (functional)	= 58 M	Cytotoxicity against human cell lines were determined	ChEMBL.	12646028

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10501148

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 20357