Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0122 | 0.7268 | 0.688 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0122 | 0.7268 | 0.688 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0122 | 0.7268 | 0.688 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.7268 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0037 | 0 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0154 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.8 nM | Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | ChEMBL. | 8230137 |
Ki (binding) | = 5.8 nM | Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | ChEMBL. | 8230137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.