Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0097 | 0.3797 | 0.6584 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0107 | 0.4597 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.006 | 0.087 | 0.0183 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0097 | 0.3797 | 1 |
Brugia malayi | Hemopexin family protein | 0.0068 | 0.1548 | 0.1666 |
Giardia lamblia | Hypothetical protein | 0.0086 | 0.2927 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0059 | 0.0786 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0097 | 0.3797 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0059 | 0.0786 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0176 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.006 | 0.087 | 0.2291 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0097 | 0.3797 | 1 |
Brugia malayi | Matrixin family protein | 0.0117 | 0.5359 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0097 | 0.3797 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0097 | 0.3797 | 0.3206 |
Chlamydia trachomatis | sulfite reductase | 0.006 | 0.087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3797 | 0.6584 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0097 | 0.3797 | 0.3206 |
Loa Loa (eye worm) | matrixin family protein | 0.0117 | 0.5359 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0107 | 0.4597 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0097 | 0.3797 | 0.3206 |
Loa Loa (eye worm) | matrixin family protein | 0.0107 | 0.4597 | 0.8334 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.006 | 0.087 | 0.0183 |
Leishmania major | p450 reductase, putative | 0.0097 | 0.3797 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0097 | 0.3797 | 1 |
Brugia malayi | flavodoxin family protein | 0.0097 | 0.3797 | 0.6584 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0097 | 0.3797 | 0.3206 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0097 | 0.3797 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0097 | 0.3797 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1548 | 0.4077 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0097 | 0.3797 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0086 | 0.2927 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0097 | 0.3797 | 0.6584 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 79 uM | Inhibition of ADP-induced aggregation of human blood platelets in plasma | ChEMBL. | 1404231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.