Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.8274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4062 | 0.491 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0032 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0058 | 0.4062 | 0.491 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0051 | 0.2999 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2999 | 0.3625 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.4062 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.4136 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.4136 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0085 | 0.8274 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.4963 | 0.5998 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.4136 | 0.4999 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.4963 | 0.5998 |
Schistosoma mansoni | DNA polymerase eta | 0.0051 | 0.2999 | 0.6714 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0.061 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0085 | 0.8274 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0051 | 0.2999 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0051 | 0.2999 | 0.3625 |
Mycobacterium ulcerans | hydrolase | 0.0032 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0085 | 0.8274 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0051 | 0.2999 | 1 |
Brugia malayi | Hemopexin family protein | 0.0037 | 0.0827 | 0.1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.62 | Inhibition of MMP8 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 0.24 uM | Inhibition of Matrix metalloproteinase-8 (Human neutrophil collagenase, MMP-8) | ChEMBL. | 9464365 |
Ki (binding) | = 0.24 uM | Inhibition of Matrix metalloproteinase-8 (Human neutrophil collagenase, MMP-8) | ChEMBL. | 9464365 |
log(1/Ki) (binding) | = 6.62 | Inhibition of MMP8 (unknown origin) | ChEMBL. | 17275314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.