Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3082 | 0.232 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3082 | 0.232 |
Chlamydia trachomatis | glutamine binding protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3082 | 0.232 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3082 | 0.232 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.3082 | 0.232 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.3082 | 0.232 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 69400 nM | Inhibition of AChE | ChEMBL. | 20053484 |
IC50 (functional) | = 3 uM | Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (functional) | = 3 uM | Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (functional) | = 4.2 uM | Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (functional) | = 4.2 uM | Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (binding) | = 18.9 uM | In vitro inhibition of Butyrylcholinesterase from human plasma. | ChEMBL. | 9357518 |
IC50 (binding) | = 18.9 uM | In vitro inhibition of Butyrylcholinesterase from human plasma. | ChEMBL. | 9357518 |
IC50 (binding) | = 69.4 uM | In vitro inhibition of acetylcholinesterase, isolated from rat brain. | ChEMBL. | 9357518 |
IC50 (binding) | = 69.4 uM | In vitro inhibition of acetylcholinesterase, isolated from rat brain. | ChEMBL. | 9357518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.