Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | intercellular adhesion molecule 1 | Starlite/ChEMBL | References |
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Homo sapiens | selectin E | Starlite/ChEMBL | References |
Homo sapiens | vascular cell adhesion molecule 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Echinococcus granulosus | c4b binding protein beta chain | selectin E | 610 aa | 551 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.1979 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.1979 | 0.1966 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0026 | 0.1979 | 0.1966 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0273 | 0.0257 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Treponema pallidum | NADH oxidase | 0.0026 | 0.1979 | 0.5 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.085 | 0.0836 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.1979 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1256 | 0.1242 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.1979 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.1979 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0128 | 0.0128 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0128 | 0.0128 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.1979 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0128 | 0.0112 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0026 | 0.1979 | 0.1966 |
Plasmodium falciparum | glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Plasmodium falciparum | thioredoxin reductase | 0.0026 | 0.1979 | 0.1966 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0026 | 0.1979 | 0.1966 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0022 | 0.1256 | 0.1242 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0128 | 0.0112 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.085 | 0.0836 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0026 | 0.1979 | 0.1966 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0128 | 0.0112 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0026 | 0.1979 | 0.1966 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 120 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 120 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 120 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 120 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.