Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0367 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0367 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0367 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0367 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0367 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0367 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0367 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0367 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0367 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0367 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase | 0.0367 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0367 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Giardia lamblia | Kinase, CMGC MAPK | 0.0367 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0367 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0367 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0367 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0367 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0367 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0367 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0367 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 nM | Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-oxotremorine-M (OXO-M); Range is 18-21 | ChEMBL. | No reference |
IC50 (binding) | = 20 nM | Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-oxotremorine-M (OXO-M); Range is 18-21 | ChEMBL. | No reference |
IC50 (binding) | = 350 nM | Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-quinuclidinyl benzilate (QNB); Range is 330-360 | ChEMBL. | No reference |
IC50 (binding) | = 350 nM | Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-quinuclidinyl benzilate (QNB); Range is 330-360 | ChEMBL. | No reference |
Ratio (binding) | 17 | Efficacy ratio was determined against Muscarinic receptor using QNB/ OXO- M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.