Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0042 | 0.0859 | 0.0995 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0358 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0311 | 0.863 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0358 | 1 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0042 | 0.0859 | 0.0995 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0042 | 0.0859 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0773 | 0.0896 |
Trichomonas vaginalis | glutaminase, putative | 0.0295 | 0.8181 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0042 | 0.0859 | 0.0995 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0042 | 0.0859 | 0.0995 |
Onchocerca volvulus | 0.0311 | 0.863 | 0.5 | |
Mycobacterium ulcerans | glutaminase | 0.0295 | 0.8181 | 0.9412 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0644 | 0.0747 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0042 | 0.0859 | 0.0995 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0311 | 0.863 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0047 | 0.1003 | 0.1162 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.1031 | 0.1195 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0925 | 0.1072 |
Loa Loa (eye worm) | glutaminase 2 | 0.0295 | 0.8181 | 0.948 |
Schistosoma mansoni | glutaminase | 0.0295 | 0.8181 | 0.948 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0042 | 0.0859 | 0.0995 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0042 | 0.0859 | 0.0995 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0148 | 0.3913 | 0.3341 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.1031 | 0.1195 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0016 | 0.0106 | 0.0123 |
Echinococcus granulosus | dihydrofolate reductase | 0.0047 | 0.1003 | 0.1162 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0644 | 0.0747 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0047 | 0.1003 | 0.1162 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0042 | 0.0859 | 0.0995 |
Echinococcus multilocularis | thymidylate synthase | 0.0311 | 0.863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0859 | 0.0995 |
Brugia malayi | hypothetical protein | 0.0148 | 0.3913 | 0.4534 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0925 | 0.1072 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0148 | 0.3913 | 0.4783 |
Schistosoma mansoni | dihydrofolate reductase | 0.0047 | 0.1003 | 0.1162 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0295 | 0.8181 | 0.948 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.0711 | 0.0869 |
Mycobacterium ulcerans | thymidylate synthase | 0.0311 | 0.863 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0042 | 0.0859 | 0.0995 |
Loa Loa (eye worm) | thymidylate synthase | 0.0311 | 0.863 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0295 | 0.8181 | 0.948 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0042 | 0.0859 | 0.0995 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0106 | 0.0123 |
Echinococcus granulosus | voltage gated potassium channel | 0.0016 | 0.0106 | 0.0123 |
Echinococcus granulosus | thymidylate synthase | 0.0311 | 0.863 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0016 | 0.0106 | 0.0123 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0925 | 0.1072 |
Brugia malayi | Dihydrofolate reductase | 0.0047 | 0.1003 | 0.1162 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0016 | 0.0106 | 0.0123 |
Loa Loa (eye worm) | calcium channel | 0.0042 | 0.0859 | 0.0995 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0042 | 0.0859 | 0.0995 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0016 | 0.0106 | 0.0123 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0042 | 0.0859 | 0.0995 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0311 | 0.863 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0148 | 0.3913 | 0.3815 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0016 | 0.0106 | 0.0123 |
Schistosoma mansoni | voltage-gated cation channel | 0.0042 | 0.0859 | 0.0995 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0042 | 0.0859 | 0.0995 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0358 | 1 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0042 | 0.0859 | 0.0995 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0042 | 0.0859 | 0.0995 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0016 | 0.0106 | 0.0123 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0047 | 0.1003 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0311 | 0.863 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0047 | 0.1003 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0859 | 0.0995 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.0711 | 0.0869 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0925 | 0.1072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CCCT (functional) | = 50 uM | Cell culture cytotoxicity of MCF-7 breast adenocarcinoma cells | ChEMBL. | 8230138 |
CCCT (functional) | = 50 uM | Cell culture cytotoxicity of MCF-7 breast adenocarcinoma cells | ChEMBL. | 8230138 |
CCCT (functional) | > 100 uM | Cell culture cytotoxicity of SW480 colon adenocarcinoma cells | ChEMBL. | 8230138 |
CCCT (functional) | > 100 uM | Cell culture cytotoxicity of SW480 colon adenocarcinoma cells | ChEMBL. | 8230138 |
Ki (binding) | = 7.37 uM | Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cells | ChEMBL. | 8230138 |
Ki (binding) | = 7.37 uM | Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cells | ChEMBL. | 8230138 |
Ki (functional) | = 72 uM | Inhibition constant against the transport of [3H]- methotrexate (MTX) by MOLT-4 T-cell | ChEMBL. | 8230138 |
Ki (functional) | = 72 uM | Inhibition constant against the transport of [3H]- methotrexate (MTX) by MOLT-4 T-cell | ChEMBL. | 8230138 |
Km (functional) | = 7.6 uM | Cytotoxicity constant for partially purified hog liver folylpolyglutamate synthetase (FPGS) | ChEMBL. | 8230138 |
V/K (ADMET) | = 7.3 | Ratio of relative velocity to that of the cytotoxicity constant | ChEMBL. | 8230138 |
Vel rem (ADMET) | = 55.2 % | Velocity compared to a control 50 microM aminopterin run on each test | ChEMBL. | 8230138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.