Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Cathepsin D | Starlite/ChEMBL | References |
Homo sapiens | renin | Starlite/ChEMBL | References |
Sus scrofa | Pepsin A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium knowlesi | aspartyl protease, putative | Pepsin A | 385 aa | 391 aa | 31.5 % |
Babesia bovis | aspartyl protease, putative | Pepsin A | 385 aa | 327 aa | 28.7 % |
Schistosoma japonicum | Lysosomal aspartic protease precursor, putative | Pepsin A | 385 aa | 324 aa | 31.2 % |
Drosophila melanogaster | CG31926 gene product from transcript CG31926-RB | Pepsin A | 385 aa | 332 aa | 40.4 % |
Plasmodium yoelii | plasmepsin | Pepsin A | 385 aa | 326 aa | 32.8 % |
Plasmodium vivax | plasmepsin IV, putative | Pepsin A | 385 aa | 323 aa | 30.0 % |
Toxoplasma gondii | aspartyl protease | Pepsin A | 385 aa | 409 aa | 31.5 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Pepsin A | 385 aa | 378 aa | 27.2 % |
Onchocerca volvulus | Putative 6-pyruvoyl tetrahydrobiopterin synthase | Pepsin A | 385 aa | 386 aa | 31.9 % |
Plasmodium knowlesi | plasmepsin IV, putative | Pepsin A | 385 aa | 323 aa | 31.0 % |
Plasmodium vivax | aspartyl protease, putative | Pepsin A | 385 aa | 365 aa | 27.7 % |
Dictyostelium discoideum | hypothetical protein | Cathepsin D | 390 aa | 374 aa | 24.9 % |
Candida albicans | secretory aspartyl proteinase SAP1p | Pepsin A | 385 aa | 331 aa | 31.1 % |
Neospora caninum | Pepsinogen A1, related | Pepsin A | 385 aa | 380 aa | 33.9 % |
Plasmodium berghei | plasmepsin V, putative | Pepsin A | 385 aa | 412 aa | 22.1 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Pepsin A | 385 aa | 341 aa | 27.9 % |
Brugia malayi | aspartic protease BmAsp-1, identical | Pepsin A | 385 aa | 385 aa | 33.0 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Pepsin A | 385 aa | 341 aa | 27.9 % |
Plasmodium falciparum | plasmepsin X | Cathepsin D | 390 aa | 351 aa | 28.8 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Pepsin A | 385 aa | 361 aa | 26.9 % |
Plasmodium falciparum | plasmepsin II | Pepsin A | 385 aa | 323 aa | 31.6 % |
Cryptosporidium hominis | aspartyl protease precursor | Pepsin A | 385 aa | 345 aa | 31.9 % |
Plasmodium falciparum | plasmepsin III | Pepsin A | 385 aa | 363 aa | 26.2 % |
Plasmodium berghei | plasmepsin IX, putative | Cathepsin D | 390 aa | 403 aa | 25.8 % |
Plasmodium yoelii | pepsinogen A-related | Cathepsin D | 390 aa | 387 aa | 25.8 % |
Plasmodium berghei | plasmepsin IV | Pepsin A | 385 aa | 369 aa | 31.7 % |
Neospora caninum | Cathepsin D enzyme (EC 3.4.23.5), related | Pepsin A | 385 aa | 353 aa | 28.3 % |
Plasmodium knowlesi | aspartyl protease, putative | Pepsin A | 385 aa | 366 aa | 27.9 % |
Plasmodium yoelii | Eukaryotic aspartyl protease, putative | Cathepsin D | 390 aa | 354 aa | 27.4 % |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | Pepsin A | 385 aa | 406 aa | 29.3 % |
Plasmodium yoelii | aspartyl protease-like | Pepsin A | 385 aa | 419 aa | 21.0 % |
Onchocerca volvulus | Sphingomyelin phosphodiesterase 1 homolog | Pepsin A | 385 aa | 386 aa | 42.0 % |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | Pepsin A | 385 aa | 377 aa | 30.0 % |
Onchocerca volvulus | Pepsin A | 385 aa | 370 aa | 21.4 % | |
Candida albicans | vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) | Pepsin A | 385 aa | 325 aa | 42.8 % |
Onchocerca volvulus | Pepsin A | 385 aa | 382 aa | 33.0 % | |
Schistosoma japonicum | Cathepsin D precursor, putative | Pepsin A | 385 aa | 328 aa | 37.8 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Pepsin A | 385 aa | 378 aa | 27.2 % |
Drosophila melanogaster | CG6508 gene product from transcript CG6508-RA | Pepsin A | 385 aa | 379 aa | 41.4 % |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | Pepsin A | 385 aa | 382 aa | 33.5 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Pepsin A | 385 aa | 361 aa | 26.9 % |
Candida albicans | secretory aspartyl proteinase SAP1p | Pepsin A | 385 aa | 331 aa | 31.1 % |
Plasmodium berghei | plasmepsin X | Cathepsin D | 390 aa | 354 aa | 27.7 % |
Plasmodium falciparum | plasmepsin VII | Pepsin A | 385 aa | 423 aa | 27.7 % |
Plasmodium falciparum | plasmepsin IX | Cathepsin D | 390 aa | 410 aa | 26.3 % |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | Pepsin A | 385 aa | 385 aa | 44.2 % |
Candida albicans | secretory aspartyl proteinase SAP8p | Pepsin A | 385 aa | 358 aa | 30.7 % |
Babesia bovis | aspartyl protease, putative | Cathepsin D | 390 aa | 339 aa | 31.3 % |
Plasmodium falciparum | plasmepsin I | Pepsin A | 385 aa | 366 aa | 30.3 % |
Plasmodium berghei | plasmepsin VII | Pepsin A | 385 aa | 410 aa | 28.5 % |
Schistosoma mansoni | cathepsin D (A01 family) | Pepsin A | 385 aa | 373 aa | 43.7 % |
Plasmodium vivax | plasmepsin V, putative | Pepsin A | 385 aa | 410 aa | 22.9 % |
Candida albicans | secretory aspartyl proteinase SAP2p | Pepsin A | 385 aa | 346 aa | 30.9 % |
Candida albicans | potential aspartic protease, weakly similar to C terminus of S. cerevisiae YPS1 (YLR120C), GPI-anchored protease | Pepsin A | 385 aa | 336 aa | 22.6 % |
Candida albicans | secretory aspartyl proteinase SAP9p, related to SAP10 | Cathepsin D | 390 aa | 315 aa | 25.1 % |
Plasmodium berghei | plasmepsin VI | Pepsin A | 385 aa | 351 aa | 31.9 % |
Toxoplasma gondii | aspartyl protease ASP1 | Pepsin A | 385 aa | 410 aa | 29.5 % |
Candida albicans | secretory aspartyl proteinase SAP3p | Pepsin A | 385 aa | 368 aa | 27.4 % |
Neospora caninum | hypothetical protein | Cathepsin D | 390 aa | 345 aa | 32.5 % |
Plasmodium falciparum | plasmepsin IV | Pepsin A | 385 aa | 323 aa | 32.2 % |
Plasmodium falciparum | plasmepsin VI | Pepsin A | 385 aa | 397 aa | 31.5 % |
Plasmodium knowlesi | eukaryotic aspartyl protease, putative | Cathepsin D | 390 aa | 350 aa | 29.1 % |
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Plasmodium knowlesi | plasmepsin V, putative | Pepsin A | 385 aa | 418 aa | 21.5 % |
Cryptosporidium parvum | secreted pepsinogen like aspartyl protease having a signal peptide | Cathepsin D | 390 aa | 387 aa | 24.0 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Pepsin A | 385 aa | 332 aa | 28.9 % |
Babesia bovis | eukaryotic aspartyl protease family protein | Pepsin A | 385 aa | 365 aa | 32.3 % |
Candida albicans | secretory aspartyl proteinase SAP3p | Pepsin A | 385 aa | 368 aa | 27.4 % |
Theileria parva | cathepsin E, putative | Pepsin A | 385 aa | 390 aa | 33.3 % |
Cryptosporidium parvum | membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain | Pepsin A | 385 aa | 346 aa | 31.8 % |
Candida albicans | secretory aspartyl proteinase SAP2p | Pepsin A | 385 aa | 346 aa | 30.9 % |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | Pepsin A | 385 aa | 363 aa | 25.3 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Pepsin A | 385 aa | 332 aa | 28.9 % |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | Pepsin A | 385 aa | 332 aa | 42.5 % |
Plasmodium vivax | aspartyl protease, putative | Cathepsin D | 390 aa | 350 aa | 28.9 % |
Candida albicans | potential aspartic protease, weakly similar to C terminus of S. cerevisiae YPS1 (YLR120C), GPI-anchored protease | Pepsin A | 385 aa | 336 aa | 22.6 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Pepsin A | 385 aa | 342 aa | 27.5 % |
Dictyostelium discoideum | hypothetical protein | Pepsin A | 385 aa | 377 aa | 29.2 % |
Candida albicans | secretory aspartyl proteinase SAP9p, related to SAP10 | Cathepsin D | 390 aa | 315 aa | 25.1 % |
Toxoplasma gondii | aspartyl protease ASP3 | Cathepsin D | 390 aa | 345 aa | 32.2 % |
Schistosoma mansoni | memapsin-2 (A01 family) | Pepsin A | 385 aa | 434 aa | 21.4 % |
Candida albicans | secretory aspartyl proteinase SAP8p | Pepsin A | 385 aa | 358 aa | 30.7 % |
Candida albicans | vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) | Pepsin A | 385 aa | 325 aa | 42.8 % |
Schistosoma mansoni | cathepsin D (A01 family) | Pepsin A | 385 aa | 375 aa | 43.7 % |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | Pepsin A | 385 aa | 330 aa | 43.9 % |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | Pepsin A | 385 aa | 330 aa | 44.5 % |
Schistosoma japonicum | ko:K01379 cathepsin D [EC3.4.23.5], putative | Pepsin A | 385 aa | 376 aa | 43.1 % |
Neospora caninum | Renin, related | Pepsin A | 385 aa | 355 aa | 29.3 % |
Plasmodium vivax | aspartyl proteinase, putative | Pepsin A | 385 aa | 380 aa | 32.1 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Pepsin A | 385 aa | 342 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pepsin A precursor | 0.0042 | 0.0169 | 0.0012 |
Onchocerca volvulus | 0.0107 | 0.1646 | 1 | |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0132 | 0.2205 | 0.8366 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.5387 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0151 | 0.2634 | 1 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.5387 | 0.5308 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.5387 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2634 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0163 | 0.0284 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0132 | 0.2205 | 0.8366 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0169 | 0.0296 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0042 | 0.0169 | 0.0012 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0042 | 0.0172 | 0.0004 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0042 | 0.0169 | 0.0012 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2634 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0239 | 0.0072 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0044 | 0.0211 | 0.0237 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0042 | 0.0172 | 0.0047 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0042 | 0.0172 | 0.0047 |
Plasmodium falciparum | plasmepsin IX | 0.014 | 0.2395 | 0.9032 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0132 | 0.2205 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0042 | 0.0172 | 0.0004 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0042 | 0.0172 | 0.0047 |
Plasmodium vivax | aspartyl protease, putative | 0.014 | 0.2395 | 0.9032 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0042 | 0.0172 | 0.0047 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0169 | 0.0012 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0477 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0239 | 0.0072 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.1646 | 0.1503 |
Plasmodium vivax | plasmepsin IV, putative | 0.0132 | 0.2205 | 0.8261 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.1646 | 0.3043 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0042 | 0.0172 | 0.0004 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0132 | 0.2205 | 0.4083 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0132 | 0.2205 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0042 | 0.0172 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.008 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0042 | 0.0172 | 0.0047 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0042 | 0.0169 | 0.0296 |
Mycobacterium ulcerans | glutaminase | 0.0273 | 0.5387 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0044 | 0.0211 | 0.0092 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.1646 | 0.2839 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.1646 | 0.7262 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0042 | 0.0172 | 0.0302 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.5387 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0042 | 0.0172 | 0.0047 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0051 | 0.0376 | 0.0826 |
Brugia malayi | dihydrofolate reductase family protein | 0.0044 | 0.0211 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0172 | 0.0302 |
Loa Loa (eye worm) | calcium channel | 0.0042 | 0.0172 | 0.0302 |
Plasmodium vivax | aspartyl protease, putative | 0.014 | 0.2395 | 0.9032 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2634 | 1 |
Plasmodium falciparum | plasmepsin X | 0.014 | 0.2395 | 0.9032 |
Plasmodium falciparum | plasmepsin VI | 0.0132 | 0.2205 | 0.8261 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0169 | 0.0012 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2634 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.5387 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0132 | 0.2205 | 0.2071 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0042 | 0.0172 | 0.062 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0376 | 0.0408 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0042 | 0.0172 | 0.0047 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0107 | 0.1646 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0042 | 0.0169 | 0.0296 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0376 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0172 | 0.0302 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0132 | 0.2205 | 0.4093 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0132 | 0.2205 | 0.8261 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0042 | 0.0169 | 0.0012 |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.1646 | 0.7262 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0042 | 0.0172 | 0.0047 |
Echinococcus granulosus | dihydrofolate reductase | 0.0044 | 0.0211 | 0.0237 |
Toxoplasma gondii | aspartyl protease | 0.0042 | 0.0169 | 0.0606 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0044 | 0.0211 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0042 | 0.0172 | 0.0047 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0042 | 0.0169 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.2205 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0169 | 0.0296 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.014 | 0.2395 | 0.9091 |
Plasmodium falciparum | plasmepsin I | 0.0132 | 0.2205 | 0.8261 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0107 | 0.1646 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0042 | 0.0172 | 0.0047 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0042 | 0.0172 | 0.0019 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0051 | 0.0376 | 0.1148 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0044 | 0.0211 | 0.0374 |
Plasmodium falciparum | plasmepsin IV | 0.0132 | 0.2205 | 0.8261 |
Mycobacterium ulcerans | thymidylate synthase | 0.0107 | 0.1646 | 0.2772 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2634 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0132 | 0.2205 | 0.8261 |
Schistosoma mansoni | dihydrofolate reductase | 0.0044 | 0.0211 | 0.0043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | In vitro inhibitory activity against human plasma renin at pH 5.5 for suppression of angiotensin I formation. | ChEMBL. | 1404233 |
IC50 (binding) | = 16 nM | In vitro inhibitory activity against human plasma renin at pH 5.5 for suppression of angiotensin I formation. | ChEMBL. | 1404233 |
IC50 (binding) | > 10000 nM | In vitro inhibitory activity was measured on bovine cathepsin D | ChEMBL. | 1404233 |
IC50 (binding) | = 10000 nM | In vitro inhibitory activity was measured on porcine pepsin. | ChEMBL. | 1404233 |
IC50 (binding) | > 10000 nM | In vitro inhibitory activity was measured on bovine cathepsin D | ChEMBL. | 1404233 |
IC50 (binding) | = 10000 nM | In vitro inhibitory activity was measured on porcine pepsin. | ChEMBL. | 1404233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.