Detailed information for compound 204409

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.916 | Formula: C19H14ClN3O3S2
  • H donors: 2 H acceptors: 4 LogP: 4.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\c1cc(CSc2nc3c(s2)ccc(c3)Cl)c(c(c1)OC)O)/C(=O)N
  • InChi: 1S/C19H14ClN3O3S2/c1-26-15-6-10(4-11(8-21)18(22)25)5-12(17(15)24)9-27-19-23-14-7-13(20)2-3-16(14)28-19/h2-7,24H,9H2,1H3,(H2,22,25)/b11-4+
  • InChiKey: GGFWNDJYHSAUAY-NYYWCZLTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens erb-b2 receptor tyrosine kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0287 0.1103 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0228 0.0228
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0109 0.0295 0.0295
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0109 0.0295 0.0458
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0287 0.1103 0.0824
Mycobacterium ulcerans proteasome PrcB 0.1459 0.6448 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.0228 0.0354
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0287 0.1103 0.1711
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.0228 0.0354
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0287 0.1103 0.1711
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.0228 0.0228
Leishmania major proteasome alpha 2 subunit, putative 0.0287 0.1103 0.0824
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0295 0.0295
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus multilocularis proteasome subunit beta type 7 0.0287 0.1103 0.1711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Entamoeba histolytica proteasome subunit beta type 1, putative 0.1133 0.4964 0.7224
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0287 0.1103 0.1711
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0228 0.0354
Brugia malayi Proteasome subunit alpha type 7-1 0.0287 0.1103 0.1103
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0295 0.0458
Schistosoma mansoni neuropeptide receptor 0.0109 0.0295 0.0458
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0287 0.1103 0.0824
Onchocerca volvulus 0.0109 0.0295 0.2676
Brugia malayi proteasome subunit alpha type 4 0.0287 0.1103 0.1103
Echinococcus multilocularis g-protein coupled receptor 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0109 0.0295 0.0295
Echinococcus granulosus proteasome subunit beta t family 0.0287 0.1103 0.1711
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0295 0.0295
Brugia malayi Tachykinin-like peptides receptor 99D 0.0109 0.0295 0.0295
Brugia malayi Proteasome A-type and B-type family protein 0.0287 0.1103 0.1103
Brugia malayi neuropeptide F receptor 0.0109 0.0295 0.0295
Echinococcus multilocularis somatostatin receptor 0.0109 0.0295 0.0458
Schistosoma mansoni hypothetical protein 0.0109 0.0295 0.0458
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0109 0.0295 0.0295
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.0228 0.0228
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0702 0.2998 0.465
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus biogenic amine 5HT receptor 0.1235 0.5428 0.8418
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0295 0.0458
Brugia malayi photoreceptor-specific nuclear receptor 0.0095 0.0228 0.0228
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0287 0.1103 0.0824
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0702 0.2998 0.465
Brugia malayi G protein-coupled receptor 0.0109 0.0295 0.0295
Plasmodium vivax proteasome subunit beta type-5, putative 0.1459 0.6448 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Echinococcus granulosus proteasome prosome macropain subunit beta 0.1133 0.4964 0.7699
Leishmania major proteasome alpha 1 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus sex peptide receptor 0.0109 0.0295 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0295 0.0458
Schistosoma mansoni amine GPCR 0.0109 0.0295 0.0458
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.2238 1 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.0321 0.0321
Schistosoma mansoni tyrosine kinase 0.0194 0.0679 0.1052
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0109 0.0295 0.0458
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus Proteasome subunit alpha beta 0.0287 0.1103 0.1711
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.0228 0.0354
Schistosoma mansoni biogenic amine receptor 0.0109 0.0295 0.0458
Leishmania major proteasome beta 2 subunit, putative 0.0287 0.1103 0.0824
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0702 0.2998 0.2779
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0295 0.0458
Echinococcus granulosus tachykinin peptides receptor 99D 0.0109 0.0295 0.0458
Loa Loa (eye worm) TYRA-2 protein 0.0109 0.0295 0.0295
Echinococcus multilocularis allatostatin A receptor 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0287 0.1103 0.1103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0287 0.1103 0.0824
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0287 0.1103 0.1711
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni tyrosine kinase 0.0191 0.0669 0.1038
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Brugia malayi nuclear receptor NHR-88 0.0095 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0057 0.0054 0.0054
Schistosoma mansoni amine GPCR 0.0109 0.0295 0.0458
Brugia malayi hypothetical protein 0.0117 0.0332 0.0332
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.0228 0.0354
Loa Loa (eye worm) proteasome subunit beta type 1 0.1133 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1459 0.6448 1
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0295 0.0458
Schistosoma mansoni hypothetical protein 0.0109 0.0295 0.0458
Schistosoma mansoni histamine h1 receptor 0.0109 0.0295 0.0458
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0295 0.0458
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0228 0.0228
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1459 0.6448 1
Onchocerca volvulus 0.0109 0.0295 0.2676
Leishmania major proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus geminin 0.0128 0.0378 0.0586
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0287 0.1103 0.0846
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0109 0.0295 0.0458
Brugia malayi Proteasome A-type and B-type family protein 0.0287 0.1103 0.1103
Giardia lamblia Proteasome subunit beta type 1 0.1133 0.4964 0.7224
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0702 0.2998 0.4091
Onchocerca volvulus 0.0109 0.0295 0.2676
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0287 0.1103 0.0824
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus orexin receptor type 2 0.0109 0.0295 0.0458
Brugia malayi AKH receptor 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis serotonin receptor 0.1235 0.5428 0.8418
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0287 0.1103 0.0824
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0109 0.0295 0.0295
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0256 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1459 0.6448 0.6337
Plasmodium falciparum proteasome subunit beta type-5 0.1459 0.6448 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0287 0.1103 0.1711
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.0228 0.0228
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.0228 0.0354
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0287 0.1103 0.1103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.0228 0.0228
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0287 0.1103 0.1711
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1459 0.6448 1
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0702 0.2998 0.465
Leishmania major proteasome beta-1 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus serotonin receptor 0.0109 0.0295 0.0458
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.0228 0.0228
Brugia malayi steroid hormone receptor 0.0095 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Echinococcus multilocularis proteasome subunit alpha type 6 0.0287 0.1103 0.1711
Brugia malayi Serotonin receptor 0.0109 0.0295 0.0295
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1459 0.6448 0.6448
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0256 0.0961 0.1491
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0702 0.2998 0.4091
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0095 0.0228 0.0354
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0109 0.0295 0.0458
Onchocerca volvulus 0.0109 0.0295 0.2676
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni tyrosine kinase 0.0115 0.0321 0.0498
Trypanosoma brucei C-8 sterol isomerase, putative 0.2238 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0109 0.0295 0.0458
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1133 0.4964 0.4806
Echinococcus multilocularis orexin receptor type 2 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis sex peptide receptor 0.0109 0.0295 0.0458
Schistosoma mansoni neuropeptide receptor 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0287 0.1103 0.1711
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.0228 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.0228 0.0228
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.0228 0.0354
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0109 0.0295 0.0458
Schistosoma mansoni amine GPCR 0.0109 0.0295 0.0458
Brugia malayi Dopamine receptor protein 2 0.0109 0.0295 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0287 0.1103 0.1711
Loa Loa (eye worm) PAS-3 protein 0.0287 0.1103 0.1103
Echinococcus granulosus hypothetical protein 0.0109 0.0295 0.0458
Schistosoma mansoni biogenic amine (5HT) receptor 0.1235 0.5428 0.8418
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0157 0.0511 0.0511
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0295 0.0458
Onchocerca volvulus 0.0109 0.0295 0.2676
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0287 0.1103 0.0824
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.0228 0.207
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.1133 0.4964 0.4806
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0702 0.2998 0.3546
Echinococcus granulosus subfamily T1A non peptidase ue 0.0287 0.1103 0.1711
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0287 0.1103 0.1711
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0287 0.1103 0.1711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.0228 0.0228
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0287 0.1103 0.1103
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1459 0.6448 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0702 0.2998 0.3546
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1459 0.6448 0.6337
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0228 0.0354
Brugia malayi proteasome subunit beta type 3 0.0287 0.1103 0.1103
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0295 0.0458
Brugia malayi nuclear hormone receptor 0.0095 0.0228 0.0228
Echinococcus multilocularis neuropeptide FF receptor 2 0.0109 0.0295 0.0458
Echinococcus granulosus proteasome prosome macropain 0.1459 0.6448 1
Echinococcus granulosus proteasome subunit alpha type 2 0.0287 0.1103 0.1711
Onchocerca volvulus 0.0111 0.0304 0.2755
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0295 0.0458
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0287 0.1103 0.0824
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0287 0.1103 0.1711
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni coup transcription factor 0.0095 0.0228 0.0354
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0109 0.0295 0.0458
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus granulosus fmrfamide receptor 0.0109 0.0295 0.0458
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0287 0.1103 0.0824
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni opsin-like receptor 0.0109 0.0295 0.0458
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0287 0.1103 0.1711
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis neuropeptide s receptor 0.0109 0.0295 0.0458
Brugia malayi RE15519p 0.0109 0.0295 0.0295
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.1133 0.4964 0.7699
Onchocerca volvulus 0.0095 0.0228 0.207
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0115 0.0321 0.0498
Trypanosoma cruzi 20S proteasome subunit 0.0702 0.2998 0.2779
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) TK/EGFR protein kinase 0.036 0.1438 0.1438
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0295 0.0458
Schistosoma mansoni opsin-like receptor 0.0109 0.0295 0.0458
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.0228 0.0354
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.0228 0.0354
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0194 0.0679 0.1052
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0702 0.2998 0.3546
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Onchocerca volvulus 0.0109 0.0295 0.2676
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0295 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0109 0.0295 0.0458
Schistosoma mansoni adenoreceptor 0.0109 0.0295 0.0458
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.0228 0.0228
Echinococcus multilocularis G protein coupled receptor 139 0.0109 0.0295 0.0458
Loa Loa (eye worm) proteasome subunit beta type 3 0.0287 0.1103 0.1103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0287 0.1103 0.0846
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0287 0.1103 0.1103
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0109 0.0295 0.0458
Echinococcus granulosus Proteasome subunit alpha type 7 0.0287 0.1103 0.1711
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0295 0.0458
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.0228 0.0354
Loa Loa (eye worm) hypothetical protein 0.1286 0.5658 0.5658
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1286 0.5658 0.8775
Brugia malayi G-protein coupled receptor 0.0109 0.0295 0.0295
Onchocerca volvulus Neuropeptide F receptor homolog 0.0109 0.0295 0.2676
Schistosoma mansoni neuropeptide f receptor 76f 0.0109 0.0295 0.0458
Brugia malayi larval opioid receptor 0.0109 0.0295 0.0295
Schistosoma mansoni growth hormone secretagogue receptor 0.0109 0.0295 0.0458
Leishmania major proteasome alpha 3 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi G-protein coupled receptor 0.0109 0.0295 0.0295
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0109 0.0295 0.0458
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.0228 0.0228
Schistosoma mansoni tyrosine kinase 0.0191 0.0669 0.1038
Toxoplasma gondii proteasome subunit beta type 1, putative 0.1133 0.4964 0.7224
Brugia malayi ORL1-like opioid receptor 0.0109 0.0295 0.0295
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0024 0.0024
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0287 0.1103 0.1711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0287 0.1103 0.1711
Echinococcus multilocularis thyroid hormone receptor alpha 0.0095 0.0228 0.0354
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Brugia malayi proteasome subunit alpha type 3 0.0287 0.1103 0.1103
Brugia malayi putative neuropeptide receptor NPR1 0.0109 0.0295 0.0295
Schistosoma mansoni amine GPCR 0.0109 0.0295 0.0458
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0109 0.0295 0.0458
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0295 0.0458
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0228 0.0354
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0115 0.0321 0.0498
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Onchocerca volvulus 0.0109 0.0295 0.2676
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.1144 0.5011 0.5011
Onchocerca volvulus 0.0109 0.0295 0.2676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.0228 0.0228
Echinococcus granulosus 7tm_1 domain containing protein 0.0109 0.0295 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus neuropeptide FF receptor 2 0.0109 0.0295 0.0458
Brugia malayi proteasome subunit alpha type 1 0.0287 0.1103 0.1103
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0287 0.1103 0.1711
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0295 0.0458
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1459 0.6448 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0109 0.0295 0.0458
Echinococcus multilocularis serotonin receptor 0.1235 0.5428 0.8418
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0109 0.0295 0.0458
Schistosoma mansoni tyrosine kinase 0.0194 0.0679 0.1052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0228 0.0354
Brugia malayi nuclear receptor RXR 0.005 0.0024 0.0024
Brugia malayi proteasome subunit beta type 1 0.1133 0.4964 0.4964
Brugia malayi hypothetical protein 0.005 0.0024 0.0024
Echinococcus multilocularis insulin receptor 0.0115 0.0321 0.0498
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0024 0.0038
Brugia malayi Dopamine receptor protein 1 0.0109 0.0295 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0228 0.0228
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0287 0.1103 0.0824
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0295 0.0458
Schistosoma mansoni neuropeptide receptor 0.0109 0.0295 0.0458
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0024 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0228 0.0354
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.0228 0.0228
Onchocerca volvulus Notchless protein homolog 0.0287 0.1103 1
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0287 0.1103 0.0824
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1133 0.4964 0.7458
Echinococcus granulosus allatostatin A receptor 0.0109 0.0295 0.0458
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Brugia malayi ecdysteroid receptor 0.0095 0.0228 0.0228
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0228 0.0354
Brugia malayi follicle stimulating hormone receptor 0.0109 0.0295 0.0295
Echinococcus multilocularis neuropeptide receptor A26 0.0109 0.0295 0.0458
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0679 0.1052
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0095 0.0228 0.0228
Brugia malayi GYF domain containing protein 0.0057 0.0054 0.0054
Echinococcus granulosus proteasome subunit beta type 7 0.0287 0.1103 0.1711
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1459 0.6448 0.6337
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0109 0.0295 0.0295
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni retinoic acid receptor RXR 0.0095 0.0228 0.0354
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0287 0.1103 0.1711
Echinococcus granulosus neuropeptide receptor A26 0.0109 0.0295 0.0458
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.1235 0.5428 0.5428
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus peptide allatostatin:somatostatin 0.0109 0.0295 0.0458
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0295 0.0458
Plasmodium falciparum proteasome subunit beta type-1, putative 0.1133 0.4964 0.7224
Trypanosoma brucei proteasome alpha 7 subunit 0.0287 0.1103 0.0824
Echinococcus granulosus g protein coupled receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus proteasome subunit alpha type 6 0.0287 0.1103 0.1711
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0287 0.1103 0.0846
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.1235 0.5428 0.5428
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0295 0.0295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0228 0.0228
Echinococcus granulosus somatostatin receptor 0.0109 0.0295 0.0458
Giardia lamblia Proteasome subunit beta type 2 0.0702 0.2998 0.3546
Schistosoma mansoni neuropeptide receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) melatonin receptor type 1A 0.0109 0.0295 0.0295
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0295 0.0458
Leishmania major C-8 sterol isomerase-like protein 0.2238 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0109 0.0295 0.0458
Leishmania major proteasome alpha 1 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis proteasome subunit beta type 6 0.0287 0.1103 0.1711
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0287 0.1103 0.0824
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0024 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.0228 0.0354
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0287 0.1103 0.5
Brugia malayi 20S proteasome alpha5 subunit 0.0287 0.1103 0.1103
Echinococcus multilocularis geminin 0.0128 0.0378 0.0586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1133 0.4964 0.4806
Loa Loa (eye worm) hypothetical protein 0.0054 0.0041 0.0041
Brugia malayi proteasome subunit alpha type 6 0.0287 0.1103 0.1103
Schistosoma mansoni tyrosine kinase 0.0191 0.0669 0.1038
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0295 0.0458
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0228 0.0354
Echinococcus granulosus insulin receptor 0.0115 0.0321 0.0498
Onchocerca volvulus Bile acid receptor homolog 0.0095 0.0228 0.207
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0287 0.1103 0.0824
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1286 0.5658 0.5658
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0287 0.1103 0.0824
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0287 0.1103 0.1711
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0295 0.0458
Plasmodium vivax proteasome subunit beta type-2, putative 0.0702 0.2998 0.3546
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0256 0.0961 0.1491
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0295 0.0295
Echinococcus granulosus 7TM GPCR rhodopsin 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0287 0.1103 0.0824
Onchocerca volvulus 0.0057 0.0054 0.0491
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0287 0.1103 0.1711
Leishmania major proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus neuropeptide s receptor 0.0109 0.0295 0.0458
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus granulosus leukotriene A 4 hydrolase 0.0256 0.0961 0.1491
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.0228 0.0354
Leishmania major proteasome beta 2 subunit, putative 0.0702 0.2998 0.2779
Echinococcus multilocularis 0.0111 0.0304 0.0472
Leishmania major proteasome beta 7 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus neuropeptide receptor 0.0109 0.0295 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.0228 0.0228
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.0228 0.0354
Brugia malayi putative neuropeptide receptor 0.0109 0.0295 0.0295
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0287 0.1103 0.1103
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0287 0.1103 0.0846
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0287 0.1103 0.1711
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus g protein coupled receptor 0.0109 0.0295 0.0458
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1459 0.6448 1
Brugia malayi sulfakinin receptor protein 0.0109 0.0295 0.0295
Schistosoma mansoni opsin-like receptor 0.0109 0.0295 0.0458
Trypanosoma brucei proteasome beta 7 subunit 0.0287 0.1103 0.0824
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.0228 0.0354
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Echinococcus multilocularis dro:myosuppressin receptor 0.0109 0.0295 0.0458
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0287 0.1103 0.1711
Echinococcus granulosus proteasome subunit beta type 6 0.0287 0.1103 0.1711
Brugia malayi hypothetical protein 0.005 0.0024 0.0024
Brugia malayi GnHR receptor homolog 0.0109 0.0295 0.0295
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0295 0.0458
Schistosoma mansoni hypothetical protein 0.0109 0.0295 0.0458
Echinococcus granulosus g-protein coupled receptor 0.0109 0.0295 0.0458
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.0228 0.0354
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.0228 0.0354
Echinococcus granulosus G protein coupled receptor 139 0.0109 0.0295 0.0458
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0287 0.1103 0.1103
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0109 0.0295 0.0458
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2238 1 1
Brugia malayi Melatonin receptor type 1A 0.0109 0.0295 0.0295
Echinococcus granulosus neuropeptide receptor 0.0109 0.0295 0.0458
Toxoplasma gondii proteasome subunit beta type, putative 0.1459 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0287 0.1103 0.1711
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0287 0.1103 0.0824
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0295 0.0458
Echinococcus granulosus g protein coupled receptor 0.0109 0.0295 0.0458
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0295 0.0458
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0287 0.1103 0.0824
Loa Loa (eye worm) proteasome subunit beta type 2 0.0702 0.2998 0.2998
Brugia malayi proteasome subunit beta type 2 0.0702 0.2998 0.2998
Brugia malayi proteasome subunit alpha type 2 0.0287 0.1103 0.1103
Onchocerca volvulus 0.0109 0.0295 0.2676
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.1133 0.4964 0.7699
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0109 0.0295 0.0295
Schistosoma mansoni biogenic amine receptor 0.0109 0.0295 0.0458
Brugia malayi Serotonin receptor 0.1486 0.6574 0.6574
Echinococcus granulosus epidermal growth factor receptor 0.036 0.1438 0.2231
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0287 0.1103 0.0846
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.0228 0.0228
Schistosoma mansoni myosin xvIII 0.0109 0.0295 0.0458
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.0228 0.0354
Brugia malayi G protein-coupled receptor F59B2.13 0.0109 0.0295 0.0295
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0024 0.0038
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0679 0.1052
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0702 0.2998 0.2779
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.0228 0.0354
Schistosoma mansoni biogenic amine receptor 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0287 0.1103 0.1711
Loa Loa (eye worm) TK/INSR protein kinase 0.0115 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.1286 0.5658 0.5658
Schistosoma mansoni tyrosine kinase 0.036 0.1438 0.2231
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.0228 0.0228
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0295 0.0458
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0295 0.0458
Schistosoma mansoni hypothetical protein 0.0128 0.0378 0.0586
Brugia malayi Pre-SET motif family protein 0.0157 0.0511 0.0511
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0109 0.0295 0.0458
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0287 0.1103 0.1711
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0287 0.1103 0.0824
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0228 0.0228
Brugia malayi Furin-like cysteine rich region family protein 0.036 0.1438 0.1438
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0109 0.0295 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Plasmodium vivax proteasome subunit beta type-1, putative 0.1133 0.4964 0.7224
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi Dopamine receptor 0.0109 0.0295 0.0295
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0287 0.1103 0.1711
Onchocerca volvulus 0.0109 0.0295 0.2676
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0287 0.1103 0.1711
Echinococcus multilocularis proteasome (prosome, macropain) 0.1459 0.6448 1
Brugia malayi Proteasome A-type and B-type family protein 0.1459 0.6448 0.6448
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0287 0.1103 0.1711
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0109 0.0295 0.2676
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0287 0.1103 0.0824
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.0228 0.0354
Brugia malayi hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0109 0.0295 0.0458
Echinococcus multilocularis proteasome subunit alpha type 2 0.0287 0.1103 0.1711
Leishmania major proteasome beta 3 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0295 0.0458
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0287 0.1103 0.1103
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0295 0.0458
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0287 0.1103 0.1103
Schistosoma mansoni tyrosine kinase 0.0115 0.0321 0.0498
Trypanosoma brucei proteasome beta 6 subunit 0.1133 0.4964 0.4806
Onchocerca volvulus 0.0178 0.0609 0.5525
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Brugia malayi Proteasome A-type and B-type family protein 0.0287 0.1103 0.1103
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0128 0.0378 0.0586
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0287 0.1103 0.0824
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0109 0.0295 0.0458
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0287 0.1103 0.0824
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.0228 0.207
Schistosoma mansoni amine GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0295 0.0458
Echinococcus granulosus dro:myosuppressin receptor 0.0109 0.0295 0.0458
Echinococcus granulosus FTZ F1 alpha 0.0095 0.0228 0.0354
Brugia malayi neuropeptide F receptor 0.0109 0.0295 0.0295
Leishmania major proteasome beta 5 subunit, putative 0.1459 0.6448 0.6337
Brugia malayi Proteasome subunit alpha type 1 0.0287 0.1103 0.1103
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0287 0.1103 0.1711
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0287 0.1103 0.1103
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0109 0.0295 0.0295
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0702 0.2998 0.465
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Echinococcus multilocularis G-protein coupled receptor, putative 0.0109 0.0295 0.0458
Echinococcus multilocularis epidermal growth factor receptor 0.036 0.1438 0.2231
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0295

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.08 Inhibitory activity against epidermal growth factor receptor (EGFR) ChEMBL. 14561085
IC50 (binding) = 4.82 Inhibitory activity tested against protein kinase HER-2 ChEMBL. 14561085
IC50 (binding) = 4.4 uM Inhibitiory concentration against EGF receptor by polyGAT phosphorylation ChEMBL. 7902440
IC50 (binding) = 4.4 uM Inhibitiory concentration against EGF receptor by polyGAT phosphorylation ChEMBL. 7902440
IC50 (functional) = 4.5 uM Inhibition of HER-14 (human EGFR over-expressing NIH3T3) cell proliferation ChEMBL. 7902440
IC50 (functional) = 4.5 uM Inhibition of HER-14 (human EGFR over-expressing NIH3T3) cell proliferation ChEMBL. 7902440
IC50 (functional) = 15 uM Inhibitiory concentration against ErbB2/neu (HER-2) by autophosphorylation ChEMBL. 7902440
IC50 (functional) = 15 uM Inhibitiory concentration against ErbB2/neu (HER-2) by autophosphorylation ChEMBL. 7902440
IC50 (binding) > 83 uM Inhibitiory concentration against EGF receptor by autophosphorylation ChEMBL. 7902440
IC50 (binding) > 83 uM Inhibitiory concentration against EGF receptor by autophosphorylation ChEMBL. 7902440
Log IC50 (binding) = 4.08 Inhibitory activity against epidermal growth factor receptor (EGFR) ChEMBL. 14561085
Log IC50 (binding) = 4.82 Inhibitory activity tested against protein kinase HER-2 ChEMBL. 14561085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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