Detailed information for compound 204493

Basic information

Technical information
  • TDR Targets ID: 204493
  • Name: N-[9-(dimethylsulfamoyl)carbazol-3-yl]morphol ine-4-carboxamide
  • MW: 402.467 | Formula: C19H22N4O4S
  • H donors: 1 H acceptors: 3 LogP: 1.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)Nc1ccc2c(c1)c1ccccc1n2S(=O)(=O)N(C)C
  • InChi: 1S/C19H22N4O4S/c1-21(2)28(25,26)23-17-6-4-3-5-15(17)16-13-14(7-8-18(16)23)20-19(24)22-9-11-27-12-10-22/h3-8,13H,9-12H2,1-2H3,(H,20,24)
  • InChiKey: KDYBUSJRQUZESZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[9-(dimethylsulfamoyl)-3-carbazolyl]-4-morpholinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SAM and MBT domain containing protein 0.004 0.0285 0.0463
Echinococcus granulosus sodium:glucose cotransporter 2 0.0032 0.0165 0.0268
Echinococcus granulosus geminin 0.0142 0.1847 0.2998
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0006 0.0015
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0012
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0006 0.0015
Schistosoma mansoni high-affinity choline transporter 0.0291 0.4132 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0 0.5
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0006 0.0015
Schistosoma mansoni inositol transporter 0.0032 0.0165 0.0399
Brugia malayi Thioredoxin reductase 0.0054 0.0495 0.1198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0012
Mycobacterium tuberculosis Possible transcriptional regulatory protein 0.0665 0.9873 0.9873
Mycobacterium tuberculosis Probable reductase 0.0122 0.1548 0.1548
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0486 0.0788
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0006 0.0015
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0006 0.0015
Loa Loa (eye worm) RNA binding protein 0.0053 0.0486 0.0936
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0032 0.0165 0.0268
Brugia malayi TAR-binding protein 0.0053 0.0486 0.1175
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0006 0.0015
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0006 0.0015
Mycobacterium ulcerans hypothetical protein 0.0665 0.9873 0.9873
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0486 0.0936
Schistosoma mansoni hypothetical protein 0.0142 0.1847 0.4469
Brugia malayi mbt repeat family protein 0.004 0.0285 0.069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.0056 0.0136
Entamoeba histolytica hypothetical protein 0.0022 0.0006 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0006 0.001
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0495 0.0954
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0495 0.0803
Echinococcus multilocularis high affinity choline transporter 1 0.0291 0.4132 0.6707
Leishmania major trypanothione reductase 0.0054 0.0495 1
Echinococcus granulosus sodium:glucose cotransporter 0.0032 0.0165 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0023
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0006 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0486 0.1175
Brugia malayi Pre-SET motif family protein 0.0174 0.2343 0.567
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0006 0.0023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1757 0.0251
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0665 0.9873 0.9873
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0006 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0056 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0023
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0673 1 1
Mycobacterium ulcerans putative regulatory protein 0.0665 0.9873 0.9873
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0032 0.0165 0.0268
Plasmodium vivax glutathione reductase, putative 0.0054 0.0495 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0006 0.0015
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1548 0.1548
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0006 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0199 0.273 0.5262
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0006 0.001
Plasmodium falciparum thioredoxin reductase 0.0054 0.0495 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0023
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0006 0.001
Echinococcus granulosus tar DNA binding protein 0.0053 0.0486 0.0788
Schistosoma mansoni sex comb on midleg homolog 0.004 0.0285 0.069
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0006 0.0012
Echinococcus multilocularis expressed protein 0.0423 0.6161 1
Entamoeba histolytica hypothetical protein 0.0022 0.0006 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.0056 0.0091
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0006 0.001
Brugia malayi RNA binding protein 0.0053 0.0486 0.1175
Brugia malayi Sodium:solute symporter family protein 0.0032 0.0165 0.0399
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0495 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0198 0.2712 1
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0673 1 1
Entamoeba histolytica hypothetical protein 0.0022 0.0006 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0174 0.2343 0.4517
Echinococcus granulosus high affinity choline transporter 1 0.0291 0.4132 0.6707
Mycobacterium tuberculosis Probable transcriptional regulatory protein (LuxR-family) 0.0665 0.9873 0.9873
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0006 0.0012
Trypanosoma brucei trypanothione reductase 0.0054 0.0495 1
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0486 0.1175
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0006 0.001
Brugia malayi hypothetical protein 0.0022 0.0006 0.0015
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0495 0.0803
Loa Loa (eye worm) hypothetical protein 0.0291 0.4132 0.7966
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0495 0.0495
Brugia malayi mbt repeat family protein 0.004 0.0285 0.069
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1548 0.1548
Schistosoma mansoni sodium/solute symporter 0.0032 0.0165 0.0399
Brugia malayi Pre-SET motif family protein 0.0025 0.0056 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0056 0.0136
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0006 0.0012
Onchocerca volvulus 0.0198 0.2712 1
Echinococcus granulosus solute carrier family 5 0.0032 0.0165 0.0268
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0006 0.001
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0247 0.3459 0.8371
Echinococcus granulosus polycomb protein SCMH1 0.004 0.0285 0.0463
Loa Loa (eye worm) hypothetical protein 0.0045 0.037 0.0713
Echinococcus multilocularis solute carrier family 5 0.0032 0.0165 0.0268
Echinococcus granulosus SAM and MBT domain containing protein 0.004 0.0285 0.0463
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0006 0.0015
Mycobacterium tuberculosis Possible two component transcriptional regulatory protein (probably LuxR-family) 0.0665 0.9873 0.9873
Echinococcus multilocularis histone acetyltransferase MYST2 0.0045 0.037 0.06
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0486 0.1175
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0006 0.0015
Brugia malayi GH02984p 0.0291 0.4132 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0006 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0023
Schistosoma mansoni sex comb on midleg homolog 0.004 0.0285 0.069
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0015
Onchocerca volvulus 0.004 0.0285 0.0862
Echinococcus multilocularis geminin 0.0142 0.1847 0.2998
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0006 0.001
Brugia malayi hypothetical protein 0.0022 0.0006 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0045 0.037 0.06
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0161 0.215 0.349
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.004 0.0285 0.069
Mycobacterium tuberculosis Probable transcriptional regulatory protein (probably LuxR/UhpA-family) 0.0665 0.9873 0.9873
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0045 0.037 0.06
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0161 0.215 0.349
Mycobacterium ulcerans two component transcriptional regulator 0.0673 1 1
Echinococcus granulosus expressed protein 0.0423 0.6161 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0549
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.0056 0.0091
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0032 0.0165 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0006 0.0015
Plasmodium vivax SET domain protein, putative 0.0025 0.0056 0.1132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0056 0.0136
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.004 0.0285 0.0862
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0006 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1757 0.1757
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0006 0.001
Loa Loa (eye worm) glutathione reductase 0.0054 0.0495 0.0954
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0006 0.0012
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0006 0.0015
Schistosoma mansoni inositol transporter 0.0032 0.0165 0.0399
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0056 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0042 0.0068
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0006 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0486 0.1175
Toxoplasma gondii thioredoxin reductase 0.0054 0.0495 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0045 0.037 0.0895
Echinococcus multilocularis polycomb protein SCMH1 0.004 0.0285 0.0463
Loa Loa (eye worm) hypothetical protein 0.0032 0.0165 0.0318
Loa Loa (eye worm) MBCTL1 0.0045 0.037 0.0713
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0486 0.1175
Loa Loa (eye worm) hypothetical protein 0.0359 0.5187 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0045 0.037 0.06
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.0056 0.1132
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0032 0.0165 0.3332
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0495 1
Schistosoma mansoni hypothetical protein 0.0142 0.1847 0.4469
Brugia malayi PXA domain containing protein 0.0022 0.0006 0.0015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0486 0.0936
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0012
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0006 0.001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1548 0.1548
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0015
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0006 0.0015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0015
Mycobacterium leprae PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN 0.0665 0.9873 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0045 0.037 0.0895
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0015
Plasmodium falciparum glutathione reductase 0.0054 0.0495 1
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0006 0.001
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0006 0.0015
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0006 0.001
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0486 0.1175
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0012
Brugia malayi PXA domain containing protein 0.0022 0.0006 0.0015
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0032 0.0165 0.0268
Brugia malayi follicle stimulating hormone receptor 0.0199 0.273 0.6606
Onchocerca volvulus 0.0032 0.0165 0.041
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0006 0.001
Brugia malayi hypothetical protein 0.0138 0.1789 0.4329
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1548 0.1548
Loa Loa (eye worm) mbt repeat family protein 0.004 0.0285 0.0549
Echinococcus granulosus sodium:myo inositol cotransporter 0.0032 0.0165 0.0268
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0006 0.0015
Brugia malayi glutathione reductase 0.0054 0.0495 0.1198

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 350 nM Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5) ChEMBL. 12139462
IC50 (binding) = 350 nM Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5) ChEMBL. 12139462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.