Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0729 | 0.301 | 0.5 |
Onchocerca volvulus | 0.0518 | 0.2098 | 1 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0211 | 0.0774 | 0.1716 |
Echinococcus granulosus | dihydrofolate reductase | 0.0211 | 0.0774 | 0.3687 |
Trypanosoma brucei | RNA helicase, putative | 0.012 | 0.0381 | 0.1264 |
Schistosoma mansoni | hypothetical protein | 0.012 | 0.0381 | 0.038 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0021 | 0.01 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0427 | 0.1705 | 0.1705 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.1782 | 0.592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0246 | 0.0926 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0012 | 0.0039 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.1782 | 0.8494 |
Brugia malayi | dihydrofolate reductase family protein | 0.0211 | 0.0774 | 0.3687 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0211 | 0.0774 | 0.3688 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1782 | 0.8494 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0246 | 0.0926 | 0.2652 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0035 | 0.0012 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0246 | 0.0926 | 0.4412 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0035 | 0.0012 | 0.0039 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0036 | 0.0035 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0035 | 0.0012 | 0.0039 |
Brugia malayi | Dihydrofolate reductase | 0.0211 | 0.0774 | 0.3687 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0246 | 0.0926 | 0.3075 |
Echinococcus multilocularis | thymidylate synthase | 0.0518 | 0.2098 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0211 | 0.0774 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0211 | 0.0774 | 0.17 |
Echinococcus granulosus | thymidylate synthase | 0.0518 | 0.2098 | 1 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.0148 | 0.05 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0729 | 0.301 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0729 | 0.301 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0518 | 0.2098 | 0.2098 |
Brugia malayi | thymidylate synthase | 0.0518 | 0.2098 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0021 | 0.0098 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0011 | 0.011 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0729 | 0.301 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0729 | 0.301 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0036 | 0.0035 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.0148 | 0.05 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.1782 | 0.592 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0011 | 0.011 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0729 | 0.301 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0211 | 0.0774 | 0.3687 |
Loa Loa (eye worm) | thymidylate synthase | 0.0518 | 0.2098 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0211 | 0.0774 | 0.0774 |
Giardia lamblia | Ribonuclease H | 0.0032 | 0 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0021 | 0.0098 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0021 | 0.0098 |
Trypanosoma brucei | unspecified product | 0.0035 | 0.0012 | 0.0039 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0518 | 0.2098 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0211 | 0.0774 | 0.17 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.1782 | 0.592 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0844 | 0.402 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0518 | 0.2098 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0518 | 0.2098 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 267 nM | Binding affinity against sigma sites in guinea pig membrane using [3H]-DTG as the radioligand | ChEMBL. | 8426363 |
IC50 (binding) | = 267 nM | Binding affinity against sigma sites in guinea pig membrane using [3H]-DTG as the radioligand | ChEMBL. | 8426363 |
IC50 (binding) | = 396 nM | Binding affinity against sigma sites in guinea pig membrane using [3H]-(+)-3-PPP as the radioligand | ChEMBL. | 8426363 |
IC50 (binding) | = 396 nM | Binding affinity against sigma sites in guinea pig membrane using [3H]-(+)-3-PPP as the radioligand | ChEMBL. | 8426363 |
Ki (binding) | = 1.83 uM | Binding affinity against D2 receptor in rat corpus striatum using [3H]-sulpiride as the radioligand | ChEMBL. | 8426363 |
Ki (binding) | = 1.83 uM | Binding affinity against D2 receptor in rat corpus striatum using [3H]-sulpiride as the radioligand | ChEMBL. | 8426363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.