Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Plasmodium vivax | vivapain-2 | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.259 | 0.5432 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0065 | 0.1573 | 0.33 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0065 | 0.1573 | 0.33 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.003 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0085 | 0.259 | 0.5432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2875 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0358 | 0.075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.003 | 0.0062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0127 | 0.4768 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2875 | 0.6031 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.003 | 0.0062 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.003 | 0.0062 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0127 | 0.4768 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.1573 | 0.3258 |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.1573 | 0.3258 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0085 | 0.259 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0042 | 0.0358 | 0.075 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0729 | 0.153 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0358 | 0.075 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0085 | 0.259 | 0.5432 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Onchocerca volvulus | 0.0036 | 0.003 | 0.0062 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0127 | 0.4768 | 1 |
Plasmodium vivax | unspecified product | 0.0065 | 0.1573 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.003 | 0.0062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.003 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0127 | 0.4768 | 1 |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.1573 | 0.3258 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0127 | 0.4768 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0127 | 0.4768 | 1 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0358 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Plasmodium vivax | vivapain-3 | 0.0065 | 0.1573 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.1573 | 0.3258 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0127 | 0.4768 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0042 | 0.0358 | 0.075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0065 | 0.1573 | 0.33 |
Onchocerca volvulus | Cathepsin L homolog | 0.0127 | 0.4768 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.003 | 0.0062 |
Onchocerca volvulus | 0.0036 | 0.003 | 0.0062 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0127 | 0.4768 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0127 | 0.4768 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0127 | 0.4768 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.003 | 0.0062 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0127 | 0.4768 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.003 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0085 | 0.259 | 0.5403 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.003 | 0.0062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.003 | 0.0062 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.003 | 0.0062 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0127 | 0.4768 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0042 | 0.0358 | 0.075 |
Onchocerca volvulus | Cathepsin L homolog | 0.0127 | 0.4768 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.003 | 0.0062 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0065 | 0.1573 | 0.33 |
Brugia malayi | Cathepsin L-like precursor | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.003 | 0.0062 |
Brugia malayi | cathepsin L-like precursor | 0.0085 | 0.259 | 0.5432 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.003 | 0.0062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0065 | 0.1573 | 0.33 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.003 | 0.0062 |
Brugia malayi | Cathepsin L-like precursor | 0.0042 | 0.0358 | 0.075 |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0729 | 0.153 |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2875 | 0.6031 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0729 | 0.153 |
Brugia malayi | Cathepsin L-like precursor | 0.0085 | 0.259 | 0.5432 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0127 | 0.4768 | 1 |
Onchocerca volvulus | 0.0085 | 0.259 | 0.5432 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.003 | 0.0062 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.1573 | 0.33 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0042 | 0.0358 | 0.075 |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0127 | 0.4768 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0065 | 0.1573 | 0.33 |
Brugia malayi | Cathepsin L-like precursor | 0.0127 | 0.4768 | 1 |
Echinococcus granulosus | cysteine protease | 0.0065 | 0.1573 | 0.33 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0127 | 0.4768 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0127 | 0.4768 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.003 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0127 | 0.4768 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.003 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0127 | 0.4768 | 1 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.259 | 0.5432 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0127 | 0.4768 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.2875 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.259 | 0.5432 |
Echinococcus granulosus | cathepsin l1 | 0.0085 | 0.259 | 0.5432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2875 | 0.6031 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.003 | 0.5 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0042 | 0.0358 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0085 | 0.259 | 0.5403 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.003 | 0.0062 |
Brugia malayi | Cathepsin L-like precursor | 0.0085 | 0.259 | 0.5432 |
Echinococcus granulosus | cathepsin L | 0.0065 | 0.1573 | 0.33 |
Loa Loa (eye worm) | ctsf protein | 0.0127 | 0.4768 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2875 | 0.6031 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.003 | 0.0062 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.003 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.003 | 0.0062 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0085 | 0.259 | 0.5432 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.003 | 0.0062 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0127 | 0.4768 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0127 | 0.4768 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.2875 | 0.6031 |
Onchocerca volvulus | 0.0127 | 0.4768 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2875 | 0.6031 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0127 | 0.4768 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0065 | 0.1573 | 0.33 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0127 | 0.4768 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.003 | 0.0062 |
Leishmania major | cathepsin L-like protease | 0.0127 | 0.4768 | 1 |
Plasmodium vivax | vivapain-1 | 0.0065 | 0.1573 | 0.33 |
Onchocerca volvulus | Cathepsin F homolog | 0.0127 | 0.4768 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0065 | 0.1573 | 0.33 |
Brugia malayi | Cathepsin L-like precursor | 0.0127 | 0.4768 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0065 | 0.1573 | 0.33 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.003 | 0.0062 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0065 | 0.1573 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0127 | 0.4768 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2875 | 0.6031 |
Echinococcus multilocularis | cathepsin L | 0.0065 | 0.1573 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0127 | 0.4768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4768 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0127 | 0.4768 | 1 |
Schistosoma mansoni | cathepsin s | 0.0042 | 0.0358 | 0.075 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0065 | 0.1573 | 0.33 |
Onchocerca volvulus | 0.0036 | 0.003 | 0.0062 | |
Plasmodium vivax | unspecified product | 0.0042 | 0.0358 | 0.075 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0127 | 0.4768 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0729 | 0.153 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0127 | 0.4768 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.003 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = -7.36 | Cytotoxicity against colon HCT-116 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -7.11 | Cytotoxicity against melanoma UACC-62 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -6.74 | Cytotoxicity against ovarian OVCAR-3 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -6.66 | Cytotoxicity against lung HOP-62 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -5.41 | Cytotoxicity against CNS SF-539 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -5.35 | Cytotoxicity against prostate DU-145 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -5.32 | Cytotoxicity against renal SN12C cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -5.13 | Cytotoxicity against breast MDA-MB-435 cell line | ChEMBL. | 12646028 |
GI50 (functional) | = -4.98 | Mean graph midpoint for growth inhibition of all human cancer cell lines. | ChEMBL. | 12646028 |
GI50 (functional) | = -0.73 | Delta is the logarithm difference between the mean graph midpoint and the most sensitive cell line | ChEMBL. | 12646028 |
GI50 (functional) | = 1.71 | Range is the logarithm difference between the log GI50 of the most resistant and the most sensitive cell lines | ChEMBL. | 12646028 |
GI50 (functional) | = 56 | Cytotoxicity against human cell lines were determined | ChEMBL. | 12646028 |
Log GI50 (functional) | = -7.36 M | Cytotoxicity against colon HCT-116 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -7.11 M | Cytotoxicity against melanoma UACC-62 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -6.74 M | Cytotoxicity against ovarian OVCAR-3 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -6.66 M | Cytotoxicity against lung HOP-62 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -5.41 M | Cytotoxicity against CNS SF-539 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -5.35 M | Cytotoxicity against prostate DU-145 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -5.32 M | Cytotoxicity against renal SN12C cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -5.13 M | Cytotoxicity against breast MDA-MB-435 cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = -4.98 M | Mean graph midpoint for growth inhibition of all human cancer cell lines. | ChEMBL. | 12646028 |
Log GI50 (functional) | = 0.73 M | Delta is the logarithm difference between the mean graph midpoint and the most sensitive cell line | ChEMBL. | 12646028 |
Log GI50 (functional) | = 1.71 M | Range is the logarithm difference between the log GI50 of the most resistant and the most sensitive cell lines | ChEMBL. | 12646028 |
Log GI50 (functional) | = 56 M | Cytotoxicity against human cell lines were determined | ChEMBL. | 12646028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.