Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | septate junction protein | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | notch | 0.0098 | 0.0224 | 0.0224 |
Onchocerca volvulus | 0.0471 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0098 | 0.0224 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0471 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | notch | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0471 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | notch | 0.0098 | 0.0224 | 0.0224 |
Onchocerca volvulus | Peroxidasin homolog | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Onchocerca volvulus | 0.0471 | 1 | 1 | |
Schistosoma mansoni | slit | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | peroxidasin | 0.0471 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0471 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0471 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0128 | 0.1008 | 0.0801 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Onchocerca volvulus | Dual oxidase homolog | 0.0471 | 1 | 1 |
Schistosoma mansoni | notch | 0.0098 | 0.0224 | 0.0224 |
Brugia malayi | Animal haem peroxidase family protein | 0.0471 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0471 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0098 | 0.0224 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0471 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0471 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | notch | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0098 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0128 | 0.1008 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0098 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0471 | 1 | 1 |
Schistosoma mansoni | notch | 0.0098 | 0.0224 | 0.0224 |
Onchocerca volvulus | 0.0471 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0471 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0471 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0098 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0128 | 0.1008 | 0.0801 |
Onchocerca volvulus | Peroxidasin homolog | 0.0471 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 uM | Blocking activity using seletin-IgG chimeras in a Selectin L competitive binding assay. | ChEMBL. | 9357520 |
IC50 (binding) | = 100 uM | Blocking activity using seletin-IgG chimeras in a Selectin P competitive binding assay. | ChEMBL. | 9357520 |
IC50 (binding) | = 280 uM | In vitro inhibitory activity against Selectin E-sialyl Lewis X (sLex) binding | ChEMBL. | 9357520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.