Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3876 | 0.462 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3876 | 0.462 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.131 | 0.0314 | 0.1148 |
Trichomonas vaginalis | conserved hypothetical protein | 0.131 | 0.0314 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3876 | 0.462 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.7082 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3876 | 0.462 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.2753 | 0.2736 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.2753 | 0.2736 | 0.2736 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3876 | 0.462 | 0.5 |
Brugia malayi | thymidylate synthase | 0.2753 | 0.2736 | 0.2736 |
Brugia malayi | sulfakinin receptor protein | 0.7082 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2753 | 0.2736 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2753 | 0.2736 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.2753 | 0.2736 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3876 | 0.462 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1123 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.2753 | 0.2736 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2753 | 0.2736 | 1 |
Onchocerca volvulus | 0.2753 | 0.2736 | 0.5 | |
Brugia malayi | hypothetical protein | 0.131 | 0.0314 | 0.0314 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.2 mg kg-1 | Effective dose determined against rat adjuvant arthritis after peroral administration | ChEMBL. | 3875725 |
ED50 (functional) | = 81 mg kg-1 | Effective dose of the compound was determined by mouse phenyl-p-benzoquinone writhing (PQW)assay after peroral administration; highest dose of the compound was tested | ChEMBL. | 3875725 |
ED50 (functional) | = 81 mg kg-1 | Effective dose of the compound was determined by mouse phenyl-p-benzoquinone writhing (PQW)assay after peroral administration; highest dose of the compound was tested | ChEMBL. | 3875725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.