Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0311 | 0.149 | 0.1471 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0221 | 0.0199 |
Brugia malayi | Carboxylesterase family protein | 0.0311 | 0.149 | 0.1471 |
Onchocerca volvulus | Peroxidasin homolog | 0.016 | 0.0652 | 0.4287 |
Loa Loa (eye worm) | animal heme peroxidase | 0.016 | 0.0652 | 0.0652 |
Schistosoma mansoni | peroxidasin | 0.016 | 0.0652 | 0.0652 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0264 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Brugia malayi | hypothetical protein | 0.016 | 0.0652 | 0.0631 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0221 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0023 | 0.0023 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0311 | 0.149 | 0.149 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.0548 | 0.0448 |
Echinococcus multilocularis | acetylcholinesterase | 0.1838 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.0029 | 0.0045 | |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0125 | 0.0456 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0567 | 0.0567 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | animal heme peroxidase | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Brugia malayi | Animal haem peroxidase family protein | 0.016 | 0.0652 | 0.0631 |
Onchocerca volvulus | Peroxidasin homolog | 0.016 | 0.0652 | 0.4287 |
Schistosoma mansoni | peroxidasin | 0.016 | 0.0652 | 0.0652 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0105 | 0.0105 |
Onchocerca volvulus | Dual oxidase homolog | 0.016 | 0.0652 | 0.4287 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0311 | 0.149 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0296 | 0.0193 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0105 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Loa Loa (eye worm) | animal heme peroxidase | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0429 | 0.0429 |
Brugia malayi | Peroxidasin | 0.016 | 0.0652 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.1838 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0031 | 0.0009 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.1048 | 0.1027 |
Echinococcus multilocularis | tumor protein p63 | 0.033 | 0.16 | 0.1581 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.1321 | 0.1301 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0321 | 0.1549 | 0.1459 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0311 | 0.149 | 0.14 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Onchocerca volvulus | 0.016 | 0.0652 | 0.4287 | |
Onchocerca volvulus | Peroxidase homolog | 0.016 | 0.0652 | 0.4287 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.0296 | 0.0274 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0311 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Echinococcus multilocularis | acetylcholinesterase | 0.1838 | 1 | 1 |
Onchocerca volvulus | 0.016 | 0.0652 | 0.4287 | |
Plasmodium falciparum | choline kinase | 0.0125 | 0.0456 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.016 | 0.0652 | 0.0631 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0311 | 0.149 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0311 | 0.149 | 0.149 |
Brugia malayi | Animal haem peroxidase family protein | 0.016 | 0.0652 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0254 | 0.1174 | 0.1174 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0105 | 0.0105 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0311 | 0.149 | 0.5 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0125 | 0.0456 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0031 | 0.0031 |
Schistosoma mansoni | integrin alpha-ps | 0.0083 | 0.0221 | 0.0221 |
Echinococcus granulosus | neuroligin | 0.0311 | 0.149 | 0.14 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0023 | 0.0023 |
Onchocerca volvulus | 0.0311 | 0.149 | 1 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.0538 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0296 | 0.0296 |
Brugia malayi | hypothetical protein | 0.0057 | 0.008 | 0.0058 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0264 | 0.016 |
Schistosoma mansoni | gliotactin | 0.0311 | 0.149 | 0.149 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.1867 | 0.1867 |
Echinococcus multilocularis | neuroligin | 0.0311 | 0.149 | 0.1471 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0138 | 0.0526 | 0.0426 |
Brugia malayi | Animal haem peroxidase family protein | 0.016 | 0.0652 | 0.0631 |
Onchocerca volvulus | 0.0311 | 0.149 | 1 | |
Onchocerca volvulus | 0.0311 | 0.149 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0311 | 0.149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1838 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0105 | 0.0105 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0311 | 0.149 | 0.1471 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.016 | 0.0652 | 0.4287 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.0789 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0062 | 0.0062 |
Onchocerca volvulus | 0.016 | 0.0652 | 0.4287 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1838 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1838 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1838 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1838 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.016 | 0.0652 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1549 | 0.1549 |
Plasmodium vivax | choline kinase, putative | 0.0125 | 0.0456 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0296 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.016 | 0.0652 | 0.0553 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Brugia malayi | Blistered cuticle protein 3 | 0.016 | 0.0652 | 0.0631 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0311 | 0.149 | 0.149 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0311 | 0.149 | 0.1471 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0031 | 0.0031 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0296 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0029 | 0.0029 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.1048 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0125 | 0.0456 | 0.0434 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 0.1549 | 0.1549 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0505 | 0.0505 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0105 | 0.0083 |
Echinococcus granulosus | integrin alpha ps | 0.0083 | 0.0221 | 0.0117 |
Loa Loa (eye worm) | animal heme peroxidase | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.1346 | 0.1346 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0321 | 0.1549 | 0.1549 |
Onchocerca volvulus | Peroxidase homolog | 0.016 | 0.0652 | 0.4287 |
Brugia malayi | Carboxylesterase family protein | 0.0311 | 0.149 | 0.1471 |
Loa Loa (eye worm) | carboxylesterase | 0.0311 | 0.149 | 0.149 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1838 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0311 | 0.149 | 0.1471 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0105 | 0.0105 |
Echinococcus granulosus | carboxylesterase 5A | 0.1838 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1838 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0538 | 0.0538 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0125 | 0.0456 | 0.0456 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.1867 | 0.1848 |
Brugia malayi | hypothetical protein | 0.0231 | 0.1048 | 0.1027 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0125 | 0.0456 | 0.0434 |
Echinococcus granulosus | tumor protein p63 | 0.033 | 0.16 | 0.1511 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0105 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0042 | 0.0042 |
Onchocerca volvulus | 0.0311 | 0.149 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.149 | 0.149 |
Brugia malayi | Carboxylesterase family protein | 0.0311 | 0.149 | 0.1471 |
Onchocerca volvulus | 0.0311 | 0.149 | 1 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0138 | 0.0526 | 0.0505 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0311 | 0.149 | 0.14 |
Echinococcus granulosus | acetylcholinesterase | 0.1838 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0311 | 0.149 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.008 | 0.008 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0793 | 0.4176 | 0.4162 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0327 | 0.0327 |
Brugia malayi | Animal haem peroxidase family protein | 0.016 | 0.0652 | 0.0631 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0031 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.008 | 0.008 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0105 | 0.0082 |
Loa Loa (eye worm) | carboxylesterase | 0.0311 | 0.149 | 0.149 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0311 | 0.149 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0311 | 0.149 | 0.149 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.008 | 0.0058 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.1321 | 0.1229 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0311 | 0.149 | 0.149 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.1001 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1048 | 0.1048 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0652 | 0.0652 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0311 | 0.149 | 0.14 |
Brugia malayi | Carboxylesterase family protein | 0.0311 | 0.149 | 0.1471 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.016 | 0.0652 | 0.0652 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0321 | 0.1549 | 0.153 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.0548 | 0.0527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.