Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2259 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.318 | 0.2565 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.318 | 0.2565 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.318 | 0.2565 | 0.5 |
Onchocerca volvulus | 0.2259 | 0 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.2259 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.2259 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.585 | 1 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.585 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2259 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.318 | 0.2565 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.2259 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.318 | 0.2565 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2259 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.318 | 0.2565 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 35 % | Decrease in paw volume of the compound was evaluated at dose 1 mg/kg | ChEMBL. | 3875725 |
ED50 (functional) | > 130 mg kg-1 | Effective dose determined by mouse phenyl-p-benzoquinone writhing (PQW) assay after peroral administration | ChEMBL. | 3875725 |
ED50 (functional) | > 130 mg kg-1 | Effective dose determined by mouse phenyl-p-benzoquinone writhing (PQW) assay after peroral administration | ChEMBL. | 3875725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.