Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.3675 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0197 | 0.3675 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.3675 | 1 |
Schistosoma mansoni | peroxidasin | 0.0197 | 0.3675 | 0.3675 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | 0.0197 | 0.3675 | 1 | |
Onchocerca volvulus | 0.0197 | 0.3675 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Echinococcus granulosus | peroxidasin | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0197 | 0.3675 | 1 |
Brugia malayi | Peroxidasin | 0.0197 | 0.3675 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Schistosoma mansoni | peroxidasin | 0.0197 | 0.3675 | 0.3675 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0197 | 0.3675 | 1 |
Giardia lamblia | High cysteine protein | 0.0064 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0197 | 0.3675 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0064 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.3675 | 1 |
Onchocerca volvulus | 0.0197 | 0.3675 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0197 | 0.3675 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.3675 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.8 uM | Transactivation potency was measured by luciferase activity in Caco- 2/TC7 cells transiently co-transfected for the fusion-protein Gal4-PPAR gamma | ChEMBL. | 12443777 |
EC50 (functional) | = 0.8 uM | Transactivation potency was measured by luciferase activity in Caco- 2/TC7 cells transiently co-transfected for the fusion-protein Gal4-PPAR gamma | ChEMBL. | 12443777 |
EC50 (functional) | = 3.8 uM | Transactivation potency was measured by luciferase activity in Caco- 2/TC7 cells transiently co-transfected for the fusion-protein Gal4-PPAR alpha | ChEMBL. | 12443777 |
EC50 (functional) | = 3.8 uM | Transactivation potency was measured by luciferase activity in Caco- 2/TC7 cells transiently co-transfected for the fusion-protein Gal4-PPAR alpha | ChEMBL. | 12443777 |
Ki (binding) | = 0.6 uM | Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome proliferator activated receptor gamma containing residues | ChEMBL. | 12443777 |
Ki (binding) | = 0.6 uM | Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome proliferator activated receptor gamma containing residues | ChEMBL. | 12443777 |
Ki (binding) | = 20 uM | Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome proliferator activated receptor alpha containing residues | ChEMBL. | 12443777 |
Ki (binding) | = 20 uM | Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome proliferator activated receptor alpha containing residues | ChEMBL. | 12443777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.