Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0612 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Onchocerca volvulus | 0.0612 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0612 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0612 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0612 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0612 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0198 | 0 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0612 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0612 | 1 | 1 |
Onchocerca volvulus | 0.0612 | 1 | 1 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0612 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0198 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0612 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0612 | 1 | 1 |
Onchocerca volvulus | 0.0612 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0612 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0612 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0612 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0612 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 1000 nM | Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells | ChEMBL. | 8784448 |
Ki (binding) | > 1000 nM | Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells | ChEMBL. | 8784448 |
Ki (binding) | = 3220 nM | In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor | ChEMBL. | 8784448 |
Ki (binding) | = 3220 nM | In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor | ChEMBL. | 8784448 |
Ki (binding) | > 10000 nM | In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1 | ChEMBL. | 8784448 |
Ki (binding) | > 10000 nM | In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1 | ChEMBL. | 8784448 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.