Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | intercellular adhesion molecule 1 | Starlite/ChEMBL | References |
Homo sapiens | selectin E | Starlite/ChEMBL | References |
Homo sapiens | vascular cell adhesion molecule 1 | Starlite/ChEMBL | References |
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Echinococcus granulosus | c4b binding protein beta chain | selectin E | 610 aa | 551 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 1 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0026 | 0.1979 | 0.1966 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0128 | 0.0128 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.1979 | 0.5 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.085 | 0.0836 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.1979 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.1979 | 0.5 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.1979 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1256 | 0.1242 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.1979 | 0.5 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0022 | 0.1256 | 0.1242 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium falciparum | thioredoxin reductase | 0.0026 | 0.1979 | 0.1966 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0128 | 0.0112 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0026 | 0.1979 | 0.1966 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0128 | 0.0112 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.085 | 0.0836 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0273 | 0.0257 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.1979 | 0.1966 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0026 | 0.1979 | 0.1966 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0128 | 0.0112 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0128 | 0.0128 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Plasmodium falciparum | glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0026 | 0.1979 | 0.1966 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0026 | 0.1979 | 0.1966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | > 1000 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.