Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Mus musculus | purine-nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine-nucleoside phosphorylase | 289 aa | 276 aa | 23.9 % |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0308 | 0.5182 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0308 | 0.5182 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0308 | 0.5182 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0308 | 0.5182 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0308 | 0.5182 | 0.5 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0308 | 0.5182 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 0.5182 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 35 nM | Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4 | ChEMBL. | 8254607 |
IC50 (binding) | = 35 nM | Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4 | ChEMBL. | 8254607 |
IC50 (binding) | = 450 nM | Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4 | ChEMBL. | 8254607 |
IC50 (binding) | = 450 nM | Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4 | ChEMBL. | 8254607 |
Ki (binding) | = 35 nM | Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | ChEMBL. | 8230137 |
Ki (binding) | = 35 nM | Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | ChEMBL. | 8230137 |
Ratio (binding) | = 13 | Ratio between IC50 at 50 mM po4 to IC50 at 1 mM po4 was determined | ChEMBL. | 8254607 |
Ratio (binding) | = 13 | Ratio between IC50 at 50 mM po4 to IC50 at 1 mM po4 was determined | ChEMBL. | 8254607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.