Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0027 | 0.0033 | 0.0033 |
Brugia malayi | hexokinase type II | 0.0027 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.004 | 0.0744 | 0.0714 |
Echinococcus granulosus | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0256 | 0.0224 |
Onchocerca volvulus | 0.0053 | 0.1471 | 0.1473 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.021 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0811 | 0.0569 |
Leishmania major | hexokinase, putative | 0.0085 | 0.3196 | 0.3173 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0256 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0073 | 0.253 | 0.2505 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0811 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1724 | 0.1724 |
Entamoeba histolytica | hexokinase 1 | 0.0085 | 0.3196 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Echinococcus multilocularis | dna polymerase eta | 0.0068 | 0.229 | 0.2088 |
Leishmania major | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0073 | 0.253 | 0.253 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Echinococcus multilocularis | hexokinase type 2 | 0.0085 | 0.3196 | 0.3017 |
Loa Loa (eye worm) | hexokinase type II | 0.0085 | 0.3196 | 0.3196 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.851 | 0.8471 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0073 | 0.253 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.851 | 0.851 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0224 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0073 | 0.253 | 0.2334 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0256 |
Trypanosoma brucei | trypanothione reductase | 0.021 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0073 | 0.253 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0033 | 0.0033 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0073 | 0.253 | 0.2505 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Entamoeba histolytica | hexokinase 2 | 0.0085 | 0.3196 | 1 |
Echinococcus multilocularis | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0811 | 0.0811 |
Leishmania major | DNA polymerase eta, putative | 0.004 | 0.0744 | 0.0714 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0073 | 0.253 | 0.2505 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0073 | 0.253 | 0.1871 |
Plasmodium falciparum | amino acid transporter, putative | 0.0031 | 0.0256 | 0.0224 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0073 | 0.253 | 0.2505 |
Leishmania major | DNA polymerase eta, putative | 0.0068 | 0.229 | 0.2265 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1464 | 0.1464 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0115 | 0.0082 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073 | 0.253 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0073 | 0.253 | 0.2505 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0068 | 0.229 | 0.2265 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0115 | 0.0082 |
Plasmodium falciparum | transporter, putative | 0.0031 | 0.0256 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Echinococcus granulosus | dna polymerase eta | 0.0068 | 0.229 | 0.2088 |
Treponema pallidum | hexokinase (hxk) | 0.0085 | 0.3196 | 0.1114 |
Onchocerca volvulus | 0.0085 | 0.3196 | 0.3562 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0115 | 0.0082 |
Loa Loa (eye worm) | thioredoxin reductase | 0.021 | 1 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0073 | 0.253 | 0.2505 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0256 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0073 | 0.253 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0073 | 0.253 | 0.2334 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0811 | 0.0781 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.851 | 0.8471 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0073 | 0.253 | 0.2505 |
Brugia malayi | hexokinase | 0.0085 | 0.3196 | 0.3196 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0073 | 0.253 | 0.1871 |
Brugia malayi | Hexokinase family protein | 0.0085 | 0.3196 | 0.3196 |
Toxoplasma gondii | hexokinase | 0.0085 | 0.3196 | 0.3173 |
Loa Loa (eye worm) | hexokinase | 0.0085 | 0.3196 | 0.3196 |
Onchocerca volvulus | 0.0085 | 0.3196 | 0.3562 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.851 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1464 | 0.1464 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0073 | 0.253 | 0.2505 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.851 | 0.851 |
Trypanosoma brucei | hexokinase, putative | 0.0085 | 0.3196 | 0.3173 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0548 | 0.03 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Loa Loa (eye worm) | hexokinase | 0.0053 | 0.1471 | 0.1471 |
Trypanosoma brucei | hexokinase | 0.0085 | 0.3196 | 0.3173 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0256 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Trypanosoma cruzi | hexokinase, putative | 0.0085 | 0.3196 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.8413 | 0.8371 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0256 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.851 | 0.8471 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0811 | 0.0569 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0073 | 0.253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.229 | 0.229 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0068 | 0.229 | 0.2265 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.851 | 0.851 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0811 | 0.0569 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0224 |
Plasmodium vivax | glutathione reductase, putative | 0.021 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.021 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.021 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.021 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0073 | 0.253 | 0.2505 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0.0256 | 0.0224 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0073 | 0.253 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0073 | 0.253 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0073 | 0.253 | 0.2505 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0811 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0115 | 0.0082 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0073 | 0.253 | 0.2505 |
Plasmodium falciparum | thioredoxin reductase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.851 | 0.851 |
Schistosoma mansoni | DNA polymerase eta | 0.0068 | 0.229 | 0.2088 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0073 | 0.253 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0811 | 0.0781 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.851 | 0.851 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0053 | 0.1478 | 0.1478 |
Plasmodium vivax | hexokinase, putative | 0.0085 | 0.3196 | 0.3173 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0053 | 0.1478 | 0.1478 |
Plasmodium falciparum | thioredoxin reductase | 0.0073 | 0.253 | 0.2505 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0.0256 | 0.0224 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0811 | 0.0781 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.851 | 0.8471 |
Echinococcus multilocularis | geminin | 0.0181 | 0.8413 | 0.8371 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0039 | 0.0039 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.004 | 0.0744 | 0.0714 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0068 | 0.229 | 0.229 |
Leishmania major | trypanothione reductase | 0.021 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Echinococcus multilocularis | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Brugia malayi | Hexokinase family protein | 0.0053 | 0.1471 | 0.1471 |
Loa Loa (eye worm) | hexokinase | 0.0085 | 0.3196 | 0.3196 |
Echinococcus granulosus | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Echinococcus multilocularis | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0811 | 0.0569 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.851 | 0.851 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0073 | 0.253 | 0.2505 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0041 | 0.0811 | 0.0811 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1464 | 0.1464 |
Onchocerca volvulus | Hexokinase homolog | 0.0053 | 0.1471 | 0.1473 |
Brugia malayi | Thioredoxin reductase | 0.021 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.021 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.8413 | 0.8371 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0041 | 0.0811 | 0.0569 |
Loa Loa (eye worm) | glutathione reductase | 0.021 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.021 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0085 | 0.3196 | 0.3173 |
Trypanosoma cruzi | hexokinase, putative | 0.0085 | 0.3196 | 0.3173 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073 | 0.253 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.3196 | 0.3562 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.851 | 0.851 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1464 | 0.1464 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0073 | 0.253 | 1 |
Echinococcus granulosus | geminin | 0.0181 | 0.8413 | 0.8371 |
Plasmodium falciparum | glutathione reductase | 0.0073 | 0.253 | 0.2505 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0073 | 0.253 | 0.2505 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0115 | 0.0082 |
Leishmania major | hexokinase, putative | 0.0085 | 0.3196 | 0.3173 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0073 | 0.253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0256 | 0.0256 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0548 | 0.0548 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0073 | 0.253 | 0.1871 |
Schistosoma mansoni | hexokinase | 0.0085 | 0.3196 | 0.3017 |
Onchocerca volvulus | 0.0182 | 0.851 | 1 | |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0073 | 0.253 | 0.2505 |
Plasmodium vivax | amine transporter, putative | 0.0031 | 0.0256 | 0.0224 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0041 | 0.0811 | 0.0569 |
Echinococcus granulosus | hexokinase type 2 | 0.0085 | 0.3196 | 0.3017 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0031 | 0.0256 | 0.0256 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0041 | 0.0811 | 0.0781 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0073 | 0.253 | 0.2334 |
Plasmodium falciparum | glutathione reductase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0548 | 0.0548 |
Trypanosoma brucei | hexokinase | 0.0085 | 0.3196 | 0.3173 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0256 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0039 | 0.0039 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 63.9 uM | Ability to inhibit [3H]-paroxetine binding to cloned human serototnin (5-HT) transporter; Average of two experiments | ChEMBL. | 15177457 |
Ki (binding) | = 63.9 uM | Ability to inhibit [3H]-paroxetine binding to cloned human serototnin (5-HT) transporter; Average of two experiments | ChEMBL. | 15177457 |
Ki (binding) | = 97.1 uM | Ability to inhibit [3H]-nisoxatine binding to cloned human norepinephrine (NE) transporter; Average of two experiments | ChEMBL. | 15177457 |
Ki (binding) | = 97.1 uM | Ability to inhibit [3H]-nisoxatine binding to cloned human norepinephrine (NE) transporter; Average of two experiments | ChEMBL. | 15177457 |
Ki (binding) | = 130 uM | Ability to inhibit [3H]-mazindol binding to cloned human dopamine (DA) transporter; Average of two experiments | ChEMBL. | 15177457 |
Ki (binding) | = 130 uM | Ability to inhibit [3H]-mazindol binding to cloned human dopamine (DA) transporter; Average of two experiments | ChEMBL. | 15177457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.