Detailed information for compound 2059686

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.396 | Formula: C17H23N5O3
  • H donors: 2 H acceptors: 3 LogP: 0.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)N1CCC2(C1)ON=C(C2)C(=O)NCc1cccnc1)C
  • InChi: 1S/C17H23N5O3/c1-12(2)20-16(24)22-7-5-17(11-22)8-14(21-25-17)15(23)19-10-13-4-3-6-18-9-13/h3-4,6,9,12H,5,7-8,10-11H2,1-2H3,(H,19,23)(H,20,24)
  • InChiKey: XCCJMTXLCYHWMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0117 0.1237 0.1245
Schistosoma mansoni cpg binding protein 0.003 0.0241 0.0242
Loa Loa (eye worm) hypothetical protein 0.0166 0.1797 0.2601
Trichomonas vaginalis esterase, putative 0.0038 0.034 0.0812
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0509 0.2834
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0104 0.0581
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.034 0.378
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.103 0.103
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.3206 0.4639
Echinococcus granulosus transcription factor btf3 0.004 0.0355 0.0357
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3206 1
Toxoplasma gondii NAC domain-containing protein 0.004 0.0355 0.1974
Loa Loa (eye worm) ICD-1 protein 0.004 0.0355 0.0513
Brugia malayi CHE-14 protein 0.0044 0.0408 0.0591
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0134 0.072
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0134 0.0282
Brugia malayi CXXC zinc finger family protein 0.0028 0.0223 0.0322
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0757 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0567 0.7165
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0166 0.1797 0.2601
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0134 0.072
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0104 0.0108
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.034 0.0907
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0355 0.157
Schistosoma mansoni tar DNA-binding protein 0.0613 0.6911 0.6953
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0486 0.1471
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.5062 0.5092
Schistosoma mansoni tar DNA-binding protein 0.0613 0.6911 0.6953
Loa Loa (eye worm) beta-lactamase 0.0038 0.034 0.0491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0038 0.034 0.1481
Loa Loa (eye worm) glutathione reductase 0.0051 0.0486 0.0703
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0147 0.1585 0.876
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0166 0.1797 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.103 0.1036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0408 0.0591
Schistosoma mansoni ap endonuclease 0.002 0.0134 0.0135
Brugia malayi RNA binding protein 0.0613 0.6911 1
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0104 0.0108
Brugia malayi beta-lactamase family protein 0.0038 0.034 0.0491
Loa Loa (eye worm) hypothetical protein 0.0103 0.1081 0.1565
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0104 0.0059
Brugia malayi hypothetical protein 0.0117 0.1237 0.1791
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0147 0.1585 0.1595
Onchocerca volvulus Putative mitochondrial import inner membrane translocase subunit tim17 0.0016 0.0086 0.0415
Mycobacterium ulcerans beta-lactamase 0.0038 0.034 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0166 0.1797 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0757 0.1095
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.034 0.0812
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0757 0.0761
Leishmania major basic transcription factor 3a, putative 0.004 0.0355 0.4007
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0567 0.2808
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0086 0.0881 0.0881
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim22 0.0016 0.0086 0.0087
Toxoplasma gondii ABC1 family protein 0.0038 0.034 0.1889
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0134 0.0282
Schistosoma mansoni mitochondrial import inner membrane translocase subunit Tim17 0.0016 0.0086 0.0087
Echinococcus multilocularis mitochondrial import inner membrane translocase 0.0016 0.0086 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.034 0.378
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2187 0.6733
Leishmania major trypanothione reductase 0.0051 0.0486 0.5961
Brugia malayi beta-lactamase 0.0038 0.034 0.0491
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.2696 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0086 0.0881 0.0886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Echinococcus granulosus expressed conserved protein 0.0097 0.101 0.1016
Brugia malayi beta-lactamase family protein 0.0038 0.034 0.0491
Schistosoma mansoni hypothetical protein 0.0185 0.2017 0.2029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0086 0.0881 0.1275
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1233 0.8575
Onchocerca volvulus 0.0038 0.034 0.164
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.034 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0166 0.1797 1
Echinococcus granulosus geminin 0.0878 0.994 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1382 0.4929
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.034 0.0907
Loa Loa (eye worm) RNA binding protein 0.0613 0.6911 1
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0147 0.1585 0.8819
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.034 1
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0567 0.3152
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0355 0.1998
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.034 0.0907
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0104 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.034 0.378
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0134 1
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0486 0.5961
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.02 0.0201
Brugia malayi hypothetical protein 0.0038 0.0331 0.0479
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.4466 0.4466
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0104 0.0274
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2187 0.6733
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0051 0.0073
Echinococcus multilocularis expressed protein 0.0147 0.1585 0.1585
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0757 0.1095
Brugia malayi RNA recognition motif domain containing protein 0.0613 0.6911 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.034 0.0812
Plasmodium falciparum glutathione reductase 0.0018 0.0104 0.0108
Loa Loa (eye worm) hypothetical protein 0.0086 0.0881 0.1275
Echinococcus granulosus dnaJ subfamily B 0.0399 0.4466 0.4493
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.103 0.103
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.207 1
Echinococcus multilocularis tar DNA binding protein 0.0613 0.6911 0.6911
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0134 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0134 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.034 0.0907
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.034 0.0342
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1382 0.4929
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1081 0.1565
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.034 0.0342
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1588 0.1597
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359
Entamoeba histolytica hypothetical protein 0.004 0.0355 0.1998
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0104 0.0274
Leishmania major hypothetical protein, conserved 0.0058 0.0567 0.7165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0355 0.0861
Plasmodium falciparum thioredoxin reductase 0.0018 0.0104 0.0108
Onchocerca volvulus 0.0038 0.034 0.164
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0016 0.0086 0.0124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0613 0.6911 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1233 0.4356
Toxoplasma gondii thioredoxin reductase 0.0051 0.0486 0.2703
Plasmodium falciparum thioredoxin reductase 0.0051 0.0486 0.2336
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Entamoeba histolytica hypothetical protein 0.0117 0.1237 1
Schistosoma mansoni hypothetical protein 0.0086 0.0881 0.0886
Echinococcus multilocularis cpg binding protein 0.003 0.0241 0.0241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0582 0.0585
Mycobacterium ulcerans hypothetical protein 0.0038 0.034 1
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1081 0.1088
Brugia malayi Probable mitochondrial import inner membrane translocase subunitTim17 0.0016 0.0086 0.0124
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0086 0.0881 0.0886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.103 0.1036
Mycobacterium tuberculosis Conserved protein 0.0038 0.034 0.0907
Loa Loa (eye worm) hypothetical protein 0.0174 0.1889 0.2734
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0408 0.0411
Schistosoma mansoni hypothetical protein 0.0166 0.1797 0.1808
Schistosoma mansoni hypothetical protein 0.0086 0.0881 0.0886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1382 0.4929
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0355 0.4007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0567 0.082
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1588 0.1588
Schistosoma mansoni tar DNA-binding protein 0.0613 0.6911 0.6953
Leishmania major hypothetical protein, conserved 0.0038 0.034 0.378
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0491
Brugia malayi N-terminal motif family protein 0.0174 0.1889 0.2734
Brugia malayi TAR-binding protein 0.0613 0.6911 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0016 0.0086 0.0479
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0124
Echinococcus multilocularis transcription factor btf3 0.004 0.0355 0.0355
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0355 0.4007
Toxoplasma gondii TIM10 family protein, putative 0.0147 0.1585 0.8819
Trypanosoma brucei trypanothione reductase 0.0051 0.0486 0.5961
Echinococcus granulosus tar DNA binding protein 0.0613 0.6911 0.6953
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3206 1
Schistosoma mansoni hypothetical protein 0.0399 0.4466 0.4493
Brugia malayi Thioredoxin reductase 0.0051 0.0486 0.0703
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0491
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0134 0.072
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0486 0.0489
Loa Loa (eye worm) hypothetical protein 0.0054 0.0522 0.0756
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0104 0.0274
Echinococcus multilocularis expressed conserved protein 0.0097 0.101 0.101
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1233 0.4356
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1081 0.1081
Echinococcus multilocularis mitochondrial import inner membrane translocase 0.0016 0.0086 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3206 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0104 0.0108
Echinococcus granulosus GPCR family 2 0.0086 0.0881 0.0886
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0757 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0757 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0134 0.0194
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.1237 0.1245
Toxoplasma gondii exonuclease III APE 0.002 0.0134 0.0747
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0166 0.1797 0.1797
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.1237 0.1237
Entamoeba histolytica hypothetical protein 0.0117 0.1237 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0134 0.0155
Echinococcus multilocularis GPCR, family 2 0.0086 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0271 0.2995 0.4334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0271 0.2995 0.4334
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.034 0.0907
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0491
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.103 0.149
Loa Loa (eye worm) hypothetical protein 0.0044 0.0408 0.0591
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0147 0.1585 0.876
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0392
Echinococcus multilocularis protein patched 0.0044 0.0408 0.0408
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0757 1
Echinococcus multilocularis geminin 0.0878 0.994 0.994
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1233 0.4356
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0104 0.0059
Echinococcus multilocularis protein dispatched 1 0.0051 0.048 0.048
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0397 0.0397
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0397 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0355 0.0861
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0408 0.0411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0271 0.2995 0.4334
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0086 0.0881 0.0881
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3206 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.02 0.02
Schistosoma mansoni transcription factor btf3 0.004 0.0355 0.0357
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0104 0.0581
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0134 0.0115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.034 0.0491
Brugia malayi hypothetical protein 0.015 0.1613 0.2335
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0104 0.0274
Echinococcus granulosus expressed protein 0.0147 0.1585 0.1595
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0757 0.0761
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0104 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0408 0.1033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.103 0.1036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0223 0.0322
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0104 0.0274
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.034 0.0491
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.034 0.0812
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0274
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.5062 0.5062
Brugia malayi beta-NAC-like protein 0.004 0.0355 0.0513
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.103 0.149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0086 0.0881 0.1275
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3206 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0757 0.0757
Echinococcus granulosus neuropeptide s receptor 0.0451 0.5062 0.5092
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.034 0.0907
Echinococcus granulosus mitochondrial import inner membrane translocase 0.0016 0.0086 0.0087
Onchocerca volvulus 0.0038 0.034 0.164
Schistosoma mansoni hypothetical protein 0.0878 0.994 1
Onchocerca volvulus 0.0028 0.0223 0.1075
Schistosoma mansoni hypothetical protein 0.0086 0.0881 0.0886
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.034 0.0907
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0567 0.7165
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.034 0.0812
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0355 0.0861
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.103 0.1036
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0016 0.0086 0.0479
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0104 0.0108
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0757 0.5641
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0567 0.2808
Loa Loa (eye worm) hypothetical protein 0.0185 0.2017 0.2918
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0274
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0486 0.0703
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0491
Schistosoma mansoni tar DNA-binding protein 0.0613 0.6911 0.6953
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.5062 0.5062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0134 0.0135
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0166 0.1797 0.2601
Schistosoma mansoni ap endonuclease 0.002 0.0134 0.0135
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1233 0.4356
Plasmodium vivax glutathione reductase, putative 0.0051 0.0486 0.2336
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0491
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1081 0.8586
Schistosoma mansoni tar DNA-binding protein 0.0613 0.6911 0.6953
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0392
Schistosoma mansoni hypothetical protein 0.0061 0.0597 0.06
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0567 0.2808
Mycobacterium tuberculosis Conserved protein 0.0038 0.034 0.0907
Schistosoma mansoni hypothetical protein 0.0086 0.0881 0.0886
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0134 0.072
Mycobacterium ulcerans lipase LipD 0.0038 0.034 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.1889 0.9127
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0491
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0134 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3206 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0486 0.0486
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0355 0.157
Loa Loa (eye worm) TAR-binding protein 0.0613 0.6911 1
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0147 0.1585 0.2294
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0166 0.1797 0.2601
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.034 0.0907
Brugia malayi glutathione reductase 0.0051 0.0486 0.0703
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.1237 0.1245
Schistosoma mansoni cpg binding protein 0.003 0.0241 0.0242
Schistosoma mansoni hypothetical protein 0.0878 0.994 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.034 0.034
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0104 0.0274
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1233 0.4356
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.034 0.0342
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0134 0.0134
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.11 0.1106
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0147 0.1585 0.2294
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359
Entamoeba histolytica hypothetical protein 0.0117 0.1237 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0134 0.1271
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0134 0.0194
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0104 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0185 0.2017 0.2918
Echinococcus granulosus polyphosphoinositide phosphatase 0.0016 0.0086 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.000006736 0.000009747
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.3206 0.4639
Brugia malayi Latrophilin receptor protein 2 0.0086 0.0881 0.1275
Brugia malayi hypothetical protein 0.015 0.1613 0.2335
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0051 0.0073
Schistosoma mansoni patched 1 0.0044 0.0408 0.0411
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0105
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0486 0.2336
Schistosoma mansoni hypothetical protein 0.0026 0.02 0.0201
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0567 0.7165
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1382 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0408 0.0408
Schistosoma mansoni cpg binding protein 0.0028 0.0223 0.0224
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0355 0.4007
Plasmodium falciparum glutathione reductase 0.0051 0.0486 0.2336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.103 0.1036
Entamoeba histolytica hypothetical protein 0.0117 0.1237 1
Mycobacterium tuberculosis Probable reductase 0.0116 0.1233 0.4356
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0104 0.0274
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.034 0.0812
Brugia malayi Calcitonin receptor-like protein seb-1 0.0271 0.2995 0.4334
Echinococcus granulosus cpg binding protein 0.003 0.0241 0.0242
Brugia malayi hypothetical protein 0.0058 0.0567 0.082
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.207 0.6359

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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