Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | secreted antigen 85-C FbpC | Get druggable targets OG5_237839 | All targets in OG5_237839 |
Mycobacterium leprae | SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) | Get druggable targets OG5_237839 | All targets in OG5_237839 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | Get druggable targets OG5_237839 | All targets in OG5_237839 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Adenosylhomocysteinase | 0.0255 | 0.1857 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0255 | 0.1857 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0255 | 0.1857 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0255 | 0.1857 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0255 | 0.1857 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0255 | 0.1857 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0255 | 0.1857 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0255 | 0.1857 | 0.5 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.1023 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0255 | 0.1857 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0255 | 0.1857 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0255 | 0.1857 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0255 | 0.1857 | 0.5 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.1023 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0255 | 0.1857 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0255 | 0.1857 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0255 | 0.1857 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0255 | 0.1857 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Growth inhibition of Mycobacterium avium 2447 | ChEMBL. | 17010479 |
IC50 (binding) | = 10 uM | In vitro concentration required to inhibit antigen 85C mycolyltransferase activity in Mycobaterium tuberculosis | ChEMBL. | 15177473 |
IC50 (binding) | = 10 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
IC50 (binding) | = 10 uM | In vitro concentration required to inhibit antigen 85C mycolyltransferase activity in Mycobaterium tuberculosis | ChEMBL. | 15177473 |
IC50 (binding) | = 10 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.