Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0029 | 0.2273 | 0.2273 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0064 | 1 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0064 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4604 | 0.0134 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.8543 | 0.8114 |
Toxoplasma gondii | exonuclease III APE | 0.0064 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0064 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.8543 | 0.8543 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0064 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.453 | 0.2921 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0064 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0064 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.4604 | 0.0134 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0064 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.453 | 0.453 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0064 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.8543 | 0.8543 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0064 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.8543 | 0.8114 |
Schistosoma mansoni | ap endonuclease | 0.0064 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.4604 | 0.4604 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0064 | 1 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0064 | 1 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0064 | 1 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0064 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0064 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0064 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0064 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.1 mg kg-1 | Ability to protect mice from lethal effects after administration of PAF (Platelet-Activating Factor) | ChEMBL. | 7658439 |
ED50 (functional) | = 0.1 mg kg-1 | Ability to protect mice from lethal effects after administration of PAF (Platelet-Activating Factor) | ChEMBL. | 7658439 |
IC50 (functional) | = 1.3 nM | In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets | ChEMBL. | 7658439 |
IC50 (functional) | = 1.3 nM | In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets | ChEMBL. | 7658439 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.