Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.013 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.013 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.013 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.013 | 1 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.013 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.013 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0045 | 0.1333 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0045 | 0.1333 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.013 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0045 | 0.1333 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0045 | 0.1333 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0045 | 0.1333 | 0.1333 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0045 | 0.1333 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.013 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.013 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0045 | 0.1333 | 0.1333 |
Treponema pallidum | NADH oxidase | 0.0045 | 0.1333 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0045 | 0.1333 | 0.1234 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0045 | 0.1333 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.013 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.013 | 1 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.013 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0045 | 0.1333 | 0.5 |
Leishmania major | trypanothione reductase | 0.013 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0045 | 0.1333 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0045 | 0.1333 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.013 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0045 | 0.1333 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10000 nM | Affinity for glycine site of NMDA receptor on rat brain membranes by displacement of [3H]- MDL 105,519. | ChEMBL. | 14505669 |
Ki (binding) | > 10000 nM | Affinity for glycine site of NMDA receptor on rat brain membranes by displacement of [3H]- MDL 105,519. | ChEMBL. | 14505669 |
Permeability (functional) | = 0.000016 | Cellular permeability in Caco-2 cells. | ChEMBL. | 14505669 |
S | > 0.22 mg ml-1 | Solubility (of methanesulfonate salt, pH 7.4) | ChEMBL. | 14505669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.