Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0041 | 0.0569 | 0.1254 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.014 | 0.014 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.417 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0116 | 0.2347 | 0.4163 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0255 | 0.5638 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.5638 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.5638 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.5638 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.5638 | 1 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.014 | 0.0249 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.014 | 0.0249 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.003 | 0.0309 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0569 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0384 | 0.068 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.002 | 0.0051 | 0.0091 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.014 | 0.014 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.005 | 0.0774 | 0.1754 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0774 | 0.5 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.417 | 1 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.005 | 0.0774 | 0.1754 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.417 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.417 | 0.6983 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.005 | 0.0774 | 0.1754 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.417 | 1 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.005 | 0.0774 | 0.1855 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0753 | 0.1257 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.0438 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0041 | 0.0569 | 0.1257 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.014 | 0.0249 |
Brugia malayi | follicle stimulating hormone receptor | 0.0116 | 0.2347 | 0.4109 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.005 | 0.0774 | 0.1372 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1312 | 0.3062 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.417 | 0.6983 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0753 | 0.1336 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3771 | 0.6161 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.003 | 0.0309 | 0.0171 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.014 | 0.016 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.014 | 0.014 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.014 | 0.014 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0255 | 0.5638 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0753 | 0.1257 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.014 | 0.014 |
Echinococcus granulosus | geminin | 0.0073 | 0.1312 | 0.3062 |
Trypanosoma brucei | hypothetical protein, conserved | 0.005 | 0.0774 | 1 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0774 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.011 | 0.2199 | 0.2199 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0774 | 0.5 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.005 | 0.0774 | 0.1855 |
Onchocerca volvulus | 0.005 | 0.0774 | 0.1853 | |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.0438 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.014 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.417 | 0.7397 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0753 | 0.1336 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.003 | 0.0309 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0384 | 0.0807 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.417 | 0.6983 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0167 | 0.3557 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.417 | 0.7373 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.014 | 0.014 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.5638 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 0.5638 | 1 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0063 | 0.1093 | 0.1093 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.005 | 0.0774 | 0.1293 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.014 | 0.014 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0063 | 0.1093 | 0.1093 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0774 | 1 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.417 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.2982 | 0.4539 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0384 | 0.0595 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.005 | 0.0774 | 0.1571 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0774 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3771 | 0.6161 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0041 | 0.0569 | 0.1257 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.014 | 0.014 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.014 | 0.014 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0774 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0041 | 0.0569 | 0.1257 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.417 | 1 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.005 | 0.0774 | 0.1754 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0774 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1312 | 0.3062 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.014 | 0.016 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.014 | 0.014 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0774 | 0.5 |
Echinococcus multilocularis | geminin | 0.0073 | 0.1312 | 0.3062 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0041 | 0.0569 | 0.0927 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.417 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.2982 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.3557 | 0.5721 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.005 | 0.0774 | 0.1754 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.417 | 0.7397 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.